Erik D. Roberson

Department of Neurology, University of Alabama at Birmingham

Affiliated withUniversity of Alabama at Birmingham

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Contemporary approaches to Alzheimer's disease and frontotemporal dementia. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20967579	2011
Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocam... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20967595	2011
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21228179	2011
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature genetics\| PubMed ID: 21460841	2011
Geriatric epilepsy: research and clinical directions for the future. Epilepsy & behavior : E&B\| PubMed ID: 21596624	2011
Mouse models of Alzheimer's disease. Brain research bulletin\| PubMed ID: 22142973	2012
Challenges and opportunities for characterizing cognitive aging across species. Frontiers in aging neuroscience\| PubMed ID: 22988434	2012
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature genetics\| PubMed ID: 23143602	2012
Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits. PloS one\| PubMed ID: 23144711	2012
Mouse models of frontotemporal dementia. Annals of neurology\| PubMed ID: 23280835	2012
Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. Journal of cell science\| PubMed ID: 23345405	2013
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23516300	2013
The dendritic hypothesis for Alzheimer's disease pathophysiology. Brain research bulletin\| PubMed ID: 24333192	2014
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. The Journal of clinical investigation\| PubMed ID: 24509083	2014
Seizure resistance without parkinsonism in aged mice after tau reduction. Neurobiology of aging\| PubMed ID: 24908165	2014
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. The Journal of experimental medicine\| PubMed ID: 25155018	2014
AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease. Journal of biomolecular screening\| PubMed ID: 25156556	2014
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA neurology\| PubMed ID: 25199842	2014
Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25471585	2014
DNA methylation slows effects of C9orf72 mutations: An epigenetic brake on genetic inheritance. Neurology\| PubMed ID: 25795647	2015
Tau-dependent kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25878292	2015
Noradrenergic dysfunction in Alzheimer's disease. Frontiers in neuroscience\| PubMed ID: 26136654	2015
The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. Human molecular genetics\| PubMed ID: 26358779	2015
Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice. eNeuro\| PubMed ID: 26361634	2015
Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease. Brain : a journal of neurology\| PubMed ID: 26598495	2015
Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test. Genes, brain, and behavior\| PubMed ID: 27213486	2016
Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Annals of neurology\| PubMed ID: 27696483	2016
Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease. Neurobiology of aging\| PubMed ID: 27793474	2017
Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia. Brain : a journal of neurology\| PubMed ID: 28379303	2017
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature genetics\| PubMed ID: 28714976	2017
F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. Annals of neurology\| PubMed ID: 28980714	2017
Genetic influences on cognition in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 29076559	2017
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 29378861	2018
Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging. Trends in neurosciences\| PubMed ID: 29555181	2018
Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. Molecular neurodegeneration\| PubMed ID: 29929528	2018
Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. Neurobiology of disease\| PubMed ID: 30448285	2019
Medical decision-making in progressive supranuclear palsy: A comparison to other neurodegenerative disorders. Parkinsonism & related disorders\| PubMed ID: 30514650	2019
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics\| PubMed ID: 30820047	2019
Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 30847382	2019
Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 31272932	2020
Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications. Journal of Alzheimer's disease : JAD\| PubMed ID: 31322571	2019
Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics\| PubMed ID: 31417202	2019
A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiology of disease\| PubMed ID: 31698056	2020
Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinic... JAMA neurology\| PubMed ID: 31710340	2020
Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 31784375	2020
Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of experimental medicine\| PubMed ID: 31826239	2020
Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles. Cold Spring Harbor molecular case studies\| PubMed ID: 31836585	2019
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta neuropathologica communications\| PubMed ID: 31870439	2019
Nonlinear Z-score modeling for improved detection of cognitive abnormality. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 31872042	2019
Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 31914217	2020
Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 31914230	2020
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science translational medicine\| PubMed ID: 31941827	2020
Neurodegenerative Disease-Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain. Frontiers in neurology\| PubMed ID: 32021611	2019
Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. American journal of human genetics\| PubMed ID: 32330418	2020
Alzheimer's disease risk gene induces Tau-dependent network hyperexcitability. eLife\| PubMed ID: 32657270	2020
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 33090700	2020
Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients. Annals of clinical and translational neurology\| PubMed ID: 33197149	2020
A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent. Journal of clinical and translational science\| PubMed ID: 33244416	2020
Brain volumetric deficits in MAPT mutation carriers: a multisite study. Annals of clinical and translational neurology\| PubMed ID: 33247623	2021
Racial Differences in Alzheimer's Disease Specialist Encounters Are Associated with Usage of Molecular Imaging and Dementia Medications: An Enterprise-Wide Analysis Using i2b2. Journal of Alzheimer's disease : JAD\| PubMed ID: 33337364	2021
Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy. PLoS genetics\| PubMed ID: 33411788	2021
Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration. Neurology\| PubMed ID: 33827960	2021
Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau. eNeuro\| PubMed ID: 33972291	2021
Dynamic Amyloid PET: Relationships to F-Flortaucipir Tau PET Measures. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 34049986	2022
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease. Nature medicine\| PubMed ID: 34155411	2021
Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice. Neurobiology of disease\| PubMed ID: 34333153	2021
Development of a multi-component intervention to promote participation of Black and Latinx individuals in biomedical research. Journal of clinical and translational science\| PubMed ID: 34367678	2021
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice. Frontiers in immunology\| PubMed ID: 35178049	2022
Influence of Subject-Specific Effects in Longitudinal Modelling of Cognitive Decline in Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 35342087	2022
TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model. Science translational medicine\| PubMed ID: 35476595	2022
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders. Cell reports. Medicine\| PubMed ID: 35492244	2022
14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer's Disease Mouse Models. eNeuro\| PubMed ID: 35697511	2022
Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults. Neurology. Clinical practice\| PubMed ID: 35747890	2022
Differences in Motor Features of , , or Variant Carriers With Familial Frontotemporal Lobar Degeneration. Neurology\| PubMed ID: 35790423	2022
Development and implementation of an electronic Clinical Dementia Rating and Financial Capacity Instrument-Short Form. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 35898521	2022
Temporal order of clinical and biomarker changes in familial frontotemporal dementia. Nature medicine\| PubMed ID: 36138153	2022
Item Response Analysis of the Financial Capacity Instrument-Short Form. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists\| PubMed ID: 36644855	2023
Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 36781744	2023
Contributions of rare and common variation to early-onset and atypical dementia risk. medRxiv : the preprint server for health sciences\| PubMed ID: 36798301	2023
Longitudinal head-to-head comparison of C-PiB and F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease. European journal of nuclear medicine and molecular imaging\| PubMed ID: 37017737	2023
Contributions of rare and common variation to early-onset and atypical dementia risk. Cold Spring Harbor molecular case studies\| PubMed ID: 37308299	2023
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia. Journal of translational medicine\| PubMed ID: 37322482	2023
Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum. Annals of neurology\| PubMed ID: 37431188	2023
Evaluation of the Electronic Clinical Dementia Rating for Dementia Screening. JAMA network open\| PubMed ID: 37707812	2023
Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals. Annals of neurology\| PubMed ID: 38038976	2024
Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 38241154	2024
Gene specific effects on brain volume and cognition of in frontotemporal lobar degeneration. medRxiv : the preprint server for health sciences\| PubMed ID: 38633784	2024
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial. JAMA neurology\| PubMed ID: 38683602	2024
Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease. Investigative ophthalmology & visual science\| PubMed ID: 38696189	2024
Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications\| PubMed ID: 38956096	2024
Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 39032157	2024
Gene-Specific Effects on Brain Volume and Cognition of in Frontotemporal Lobar Degeneration. Neurology\| PubMed ID: 39321401	2024
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models. Cell reports\| PubMed ID: 39427315	2024
Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 39713899	2025
Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders. Molecular neurodegeneration\| PubMed ID: 40075459	2025
Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 40277074	2025
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nature aging\| PubMed ID: 40380000	2025
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease. Acta neuropathologica\| PubMed ID: 40459787	2025