novel-mini-open-transforaminal-lumbar-interbody-fusion

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Transforaminal lumbar interbody fusion (TLIF) is an effective and popular surgical procedure for managing various spinal pathologies, particularly ...

The Second Affiliated Hospital of Soochow University

Transplantation of olfactory ensheathing cells (OECs) is currently considered to be one of the most promising repair strategies for human spinal cord injury. However, the factors that regulate OECs are still poorly understood. Ginsenoside Rg1 (Rg1), the phytosterol from Panax ginseng, is a potent neuroprotective agent that promotes axonal regeneration. The aim of this study is to determine whether Rg1 would influence the biological activity of OECs. Primary cultured OECs from the olfactory bulb of neonatal rats were treated with Rg1 of various concentrations and durations. Using MTT and bromodeoxyuridine assays, we found that Rg1 significantly promoted cell proliferation, with an optimal concentration of 40 mug/ml of Rg1 at 72 h. In addition, RT-PCR and ELISA assays showed that Rg1 could upregulate the mRNA expression and secretion of glial cell-derived neurotrophic factor, brain-derived neurotrophic factor, and nerve growth factor. These results suggest that Rg1 may have a great potential in OEC therapy.

Ginsenoside Rg1 promotes proliferation and neurotrophin expression of olfactory ensheathing cells.

Zur Bewertung der Wirksamkeit der posteriore Instrumentierung plus Vertebroplastie und Posterolaterale Fusion mit Calciumsulfat f&uuml;r thoracolumbar Platzen Frakturen ohne neurologische Defizite.

Pedikelschrauben Schraube Instrumentierung sowie Vergr&ouml;&szlig;erung Vertebroplastie mit Calciumsulfat f&uuml;r thoracolumbar Platzen Frakturen ohne neurologische Defizite.

Per valutare l&#39;efficacia della fusione strumentazione plus vertebroplastica e postero-laterale posteriore con solfato di calcio per fratture toraco burst senza deficit neurologici.

Peduncolo vite strumentazione plus augmentation vertebroplastica con solfato di calcio per fratture toraco burst senza deficit neurologici.

&#x4EE5;&#x8BC4;&#x4F30;&#x540E;&#x7684;&#x4EEA;&#x5668;&#x52A0;&#x690E;&#x4F53;&#x6210;&#x5F62;&#x672F;&#x548C;&#x540E;&#x5916;&#x4FA7;&#x878D;&#x5408;&#xFF0C;&#x4F7F;&#x7528;&#x786B;&#x9178;&#x9499;&#x65E0;&#x795E;&#x7ECF;&#x75C7;&#x72B6;&#x80F8;&#x8170;&#x690E;&#x7206;&#x88C2;&#x6027;&#x9AA8;&#x6298;&#x7684;&#x7597;&#x6548;&#x3002;

&#x690E;&#x5F13;&#x6839;&#x87BA;&#x9489;&#x4EEA;&#x8868;&#x52A0;&#x6269;&#x5145;&#x690E;&#x4F53;&#x786B;&#x9178;&#x9499;&#x65E0;&#x795E;&#x7ECF;&#x75C7;&#x72B6;&#x80F8;&#x8170;&#x690E;&#x7206;&#x88C2;&#x6027;&#x9AA8;&#x6298;&#x3002;

To evaluate the efficacy of posterior instrumentation plus vertebroplasty and posterolateral fusion using calcium sulfate for thoracolumbar burst fractures without neurologic deficits.

Pedicle screw instrumentation plus augmentation vertebroplasty using calcium sulfate for thoracolumbar burst fractures without neurologic deficits.

Pour &eacute;valuer l&#39;efficacit&eacute; de la fusion post&eacute;rieure d&#39;instrumentation plus vert&eacute;broplastie et post&eacute;ro-lat&eacute;rales &agrave; l&#39;aide de sulfate de calcium pour les fractures thoraco-lombaire rafale sans d&eacute;ficits neurologiques.

P&eacute;dicule vis instrumentation plus augmentation mammaire vert&eacute;broplastie &agrave; l&#39;aide de sulfate de calcium pour les fractures thoraco-lombaire rafale sans d&eacute;ficits neurologiques.

&#x795E;&#x7D4C;&#x969C;&#x5BB3;&#x3092;&#x5448;&#x3059;&#x308B;&#x306A;&#x3057;&#x80F8;&#x8170;&#x690E;&#x7834;&#x88C2;&#x9AA8;&#x6298;&#x306B;&#x5BFE;&#x3059;&#x308B;&#x786B;&#x9178;&#x30AB;&#x30EB;&#x30B7;&#x30A6;&#x30E0;&#x3092;&#x7528;&#x3044;&#x305F;&#x5F8C;&#x90E8;&#x306E;&#x30A4;&#x30F3;&#x30B9;&#x30C8;&#x30EB;&#x30E1;&#x30F3;&#x30C6;&#x30FC;&#x30B7;&#x30E7;&#x30F3; &#x30D7;&#x30E9;&#x30B9;&#x690E;&#x4F53;&#x5F62;&#x6210;&#x8853;&#x3068;&#x5F8C;&#x5916;&#x5074;&#x306E;&#x878D;&#x5408;&#x306E;&#x6709;&#x52B9;&#x6027;&#x3092;&#x8A55;&#x4FA1;&#x3059;&#x308B;&#x306B;&#x306F;&#x3002;

&#x795E;&#x7D4C;&#x969C;&#x5BB3;&#x3092;&#x5448;&#x3059;&#x308B;&#x306A;&#x3057;&#x80F8;&#x8170;&#x690E;&#x7834;&#x88C2;&#x9AA8;&#x6298;&#x306B;&#x5BFE;&#x3059;&#x308B;&#x786B;&#x9178;&#x30AB;&#x30EB;&#x30B7;&#x30A6;&#x30E0;&#x3092;&#x7528;&#x3044;&#x305F;&#x690E;&#x5F13;&#x6839;&#x30B9;&#x30AF;&#x30EA;&#x30E5;&#x30FC; &#x30A4;&#x30F3;&#x30B9;&#x30C8;&#x30EB;&#x30E1;&#x30F3;&#x30C6;&#x30FC;&#x30B7;&#x30E7;&#x30F3; &#x30D7;&#x30E9;&#x30B9;&#x8C4A;&#x80F8;&#x690E;&#x3002;

&#xCE7C;&#xC298; &#xD669;&#xC0B0;&#xC744; &#xC0AC;&#xC6A9; &#xD558; &#xC5EC; &#xC2E0;&#xACBD;&#xD559; &#xC0C1; &#xC801;&#xC790; &#xC5C6;&#xC774; thoracolumbar &#xD30C;&#xC5F4; &#xACE8;&#xC808;&#xC5D0; &#xB300; &#xD55C; &#xC0AC;&#xD6C4; &#xACC4;&#xCE21; &#xD50C;&#xB7EC;&#xC2A4; vertebroplasty &#xBC0F; posterolateral &#xD4E8;&#xC804;&#xC758; &#xD6A8;&#xB2A5; &#xD3C9;&#xAC00;.

Pedicle &#xB098;&#xC0AC; &#xACC4;&#xCE21; &#xD50C;&#xB7EC;&#xC2A4; &#xD655;&#xB300; vertebroplasty &#xC2E0;&#xACBD;&#xD559; &#xC0C1; &#xC801;&#xC790; &#xC5C6;&#xC774; thoracolumbar &#xD30C;&#xC5F4; &#xACE8;&#xC808;&#xC5D0; &#xB300; &#xD55C; &#xCE7C;&#xC298; &#xD669;&#xC0B0;&#xC744; &#xC0AC;&#xC6A9; &#xD558; &#xC5EC;.

Evaluar la eficacia de la fusi&oacute;n posterior instrumentaci&oacute;n m&aacute;s vertebroplastia y posterolateral con sulfato de calcio para las fracturas toracolumbares sin d&eacute;ficits neurol&oacute;gicos.

Pedicle tornillo instrumentaci&oacute;n m&aacute;s aumento vertebroplastia con sulfato de calcio para las fracturas toracolumbares sin d&eacute;ficits neurol&oacute;gicos.

To describe the applications and effects of electromagnetic navigation (EN) technology in distal locking for the treatment of long diaphyseal fracture (LDF) with interlocking intramedullary nailing (IIN).

Electromagnetic Navigation in Distal Locking of Long Diaphyseal Interlocking Intramedullary Nailing.

The aim of this study was to determine the effects of ginsenoside Rg1 on the migration of olfactory ensheathing cells (OECs) in vitro, and its influence on the therapeutic efficacy of OECs transplanted in vivo for the treatment of spinal cord injury (SCI). Primary cultured and purified OECs (prepared from rats) were treated with ginsenoside Rg1. The wound healing test indicated that ginsenoside Rg1 promoted the migration of OECs. Real-time RT-PCR demonstrated that ginsenoside Rg1 upregulated the expression of migration-related factors of OECs, including matrix metalloproteinases-2 (MMP-2), MMP-9, and neural cell adhesion molecule 1 (NCAM1). Moreover, Western blot analysis indicated that ginsenoside Rg1 significantly promoted the migration of OECs via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. An SCI rat model was induced in vivo using a revised Allen's method. The Basso, Beattie, and Bresnahan (BBB) scores and histological analysis demonstrated that OECs, which were treated with ginsenoside Rg1, exhibited significant improvement in SCI compared with both the control group and the OEC group. Thus, ginsenoside Rg1 may represent a novel treatment target for SCI.

Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells via the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury.

To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI).

Ginsenoside Rg1-induced activation of astrocytes promotes functional recovery via the PI3K/Akt signaling pathway following spinal cord injury.

Surgical site infection (SSI) is one of the most intractable complications following spine surgery during the early postoperative stage. Elderly (age > 70 years), body mass index > 30, smoking, diabetes mellitus, coronary artery disease, chronic obstructive pulmonary disease, anemia, low serum albumin, operation time > 3 h, and perioperative blood loss > 500 mL are the common risk factors of SSI after spine surgery. However, there are few published reports about sweat contamination induced surgical site infections with Staphylococcus epidermidis up to date. Staphylococcus epidermidis is a permanent member of the normal human microbiota and has emerged as an important opportunistic pathogen in SSI. We aim to detect the influence of sweat infiltration on SSI with Staphylococcus epidermidis and effective management.

Sweat contamination induced surgical site infections after spine surgery: Three case reports and literature review.

Transforaminal lumbar interbody fusion (TLIF) is an effective and popular surgical procedure for the management of various spinal pathologies, especially degenerative diseases. Surgeons have been pursuing minimally invasive technology as soon as TLIF was appeared. Currently, TLIF can be performed with transforaminal approaches by open surgery, minimally invasive surgery or percutaneous endoscope. We provide a detailed description of a new modified open TLIF with percutaneous pedicle screws, which we refer to as mini-open TLIF. The objective of this study was to present feasibility of this procedure and the preliminary results.

A novel mini-open transforaminal lumbar interbody fusion for lumbar degenerative diseases: technical note and preliminary results.

and purpose: Postoperative fatigue (POF) is a common and distressing post-operative symptom. This study aimed to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and POF in elderly patients with hip fracture.

Association between neutrophil-to-lymphocyte ratio and postoperative fatigue in elderly patients with hip fracture.

Ginseng (Panax ginseng C. A. Mey) is a common traditional Chinese medicine used for anti-inflammation, anti-apoptosis, anti-oxidative stress, and neuroprotection. Ginsenosides Rg1, the main active components isolated from ginseng, may be a feasible therapy for spinal cord injury (SCI).

Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway.

To compare the clinical and radiological outcomes of modified mini-open transforaminal lumbar interbody fusion (mMO-TLIF) via posterior midline incision for "targeted limited dissection" versus minimal invasive transforaminal lumbar interbody fusion (MIS-TLIF) via Wiltse approach in lumbar degenerative diseases.

Comparison of mMO-TLIF via Midline Incision Versus MIS-TLIF via Wiltse Approach in Lumbar Degenerative Disease.

To investigate the regulation of ginsenoside Rg1 on the PI3K/AKT pathway through the lncRNA-Malat1/miR-124-3p/ Laminin gamma1 (Lamc1) axis, activating astrocytes (As) to promote the repair of spinal cord injury (SCI).

Ginsenoside Rg1 Regulates the Activation of Astrocytes Through lncRNA-Malat1/miR-124-3p/Lamc1 Axis Driving PI3K/AKT Signaling Pathway, Promoting the Repair of Spinal Cord Injury.

Article	Year
Ginsenoside Rg1 promotes proliferation and neurotrophin expression of olfactory ensheathing cells. Journal of Asian natural products research\| PubMed ID: 20419536	2010
Pedicle screw instrumentation plus augmentation vertebroplasty using calcium sulfate for thoracolumbar burst fractures without neurologic deficits. Orthopaedic surgery\| PubMed ID: 22009973	2011
Electromagnetic Navigation in Distal Locking of Long Diaphyseal Interlocking Intramedullary Nailing. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP\| PubMed ID: 28043310	2016
Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells via the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury. Biological & pharmaceutical bulletin\| PubMed ID: 28966235	2017
Ginsenoside Rg1-induced activation of astrocytes promotes functional recovery via the PI3K/Akt signaling pathway following spinal cord injury. Life sciences\| PubMed ID: 32259600	2020
Sweat contamination induced surgical site infections after spine surgery: Three case reports and literature review. International journal of surgery case reports\| PubMed ID: 35658310	2022
A novel mini-open transforaminal lumbar interbody fusion for lumbar degenerative diseases: technical note and preliminary results. Journal of orthopaedic surgery and research\| PubMed ID: 37475005	2023
Association between neutrophil-to-lymphocyte ratio and postoperative fatigue in elderly patients with hip fracture. Heliyon\| PubMed ID: 38144319	2023
Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway. Journal of ethnopharmacology\| PubMed ID: 38971343	2024
Comparison of mMO-TLIF via Midline Incision Versus MIS-TLIF via Wiltse Approach in Lumbar Degenerative Disease. Indian journal of orthopaedics\| PubMed ID: 39170666	2024
Ginsenoside Rg1 Regulates the Activation of Astrocytes Through lncRNA-Malat1/miR-124-3p/Lamc1 Axis Driving PI3K/AKT Signaling Pathway, Promoting the Repair of Spinal Cord Injury. CNS neuroscience & therapeutics\| PubMed ID: 39491316	2024

Zhengfeng Lu

Biography

JoVE Journal Publications

Other Publications