Kenneth B. Margulies

Cardiovascular Institute, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18359894	2008
Increased cardiac myocyte progenitors in failing human hearts. Circulation\| PubMed ID: 18645055	2008
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation\| PubMed ID: 19237659	2009
Genomics, transcriptional profiling, and heart failure. Journal of the American College of Cardiology\| PubMed ID: 19422981	2009
Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium. Circulation. Heart failure\| PubMed ID: 19808314	2009
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. The Journal of clinical investigation\| PubMed ID: 19855129	2009
Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation. Cardiovascular genetics\| PubMed ID: 20031553	2008
Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Circulation. Cardiovascular genetics\| PubMed ID: 20031589	2009
Reciprocal regulation of metabolic and signaling pathways. BMC genomics\| PubMed ID: 20334672	2010
Current status of stem cell therapy in heart failure. Current cardiology reports\| PubMed ID: 20424962	2010
Strong synaptic transmission impact by copy number variations in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20489179	2010
Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management. The Journal of cardiovascular nursing\| PubMed ID: 21263344	2011
Homeodomain only protein x is down-regulated in human heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 21382376	2011
Decreased cardiac functional reserve in heart failure with preserved systolic function. Journal of cardiac failure\| PubMed ID: 21440868	2011
Differential regulation of PDE5 expression in left and right ventricles of feline hypertrophy models. PloS one\| PubMed ID: 21625548	2011
Functional genomics applied to cardiovascular medicine. Circulation\| PubMed ID: 21730321	2011
Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circulation. Cardiovascular genetics\| PubMed ID: 21828333	2011
Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart. Journal of molecular and cellular cardiology\| PubMed ID: 22047808	2012
A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues. Tissue engineering. Part A\| PubMed ID: 22092279	2012
Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte. Journal of molecular and cellular cardiology\| PubMed ID: 22133375	2012
Differential expression of PDE5 in failing and nonfailing human myocardium. Circulation. Heart failure\| PubMed ID: 22135403	2012
Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circulation research\| PubMed ID: 22275486	2012
Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. Biomaterials\| PubMed ID: 22835643	2012
Hybrid mathematical model of cardiomyocyte turnover in the adult human heart. PloS one\| PubMed ID: 23284740	2012
Management of ventricular arrhythmias in patients with ventricular assist devices. Current opinion in cardiology\| PubMed ID: 23549232	2013
Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation\| PubMed ID: 23589024	2013
BET bromodomains mediate transcriptional pause release in heart failure. Cell\| PubMed ID: 23911322	2013
Gene expression and genetic variation in human atria. Heart rhythm\| PubMed ID: 24177373	2014
Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA\| PubMed ID: 24247300	2013
Dynamic left ventricular assist device inflow obstruction. Circulation. Heart failure\| PubMed ID: 24449814	2014
A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine ... Circulation. Heart failure\| PubMed ID: 24902740	2014
Anti-inflammatory loaded poly-lactic glycolic acid nanoparticle formulations to enhance myocardial gene transfer: an in-vitro assessment of a drug/gene combination therapeutic approach for d... Journal of translational medicine\| PubMed ID: 24934216	2014
GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circulation. Heart failure\| PubMed ID: 25028349	2014
Epigenetic memory and cardiac cell therapy. Journal of the American College of Cardiology\| PubMed ID: 25082576	2014
Emerging Tools for Computer-Aided Diagnosis and Prognostication. Journal of clinical trials\| PubMed ID: 25143872	2014
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Journal of the American Heart Association\| PubMed ID: 25146704	2014
RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics\| PubMed ID: 25528681	2015
Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation\| PubMed ID: 25533966	2015
Ventricular assist device thrombosis: A wide spectrum of clinical presentation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 25703960	2015
Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circulation. Heart failure\| PubMed ID: 25782985	2015
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature\| PubMed ID: 25799991	2015
CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. Journal of proteome research\| PubMed ID: 25815641	2015
Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries. Journal of cardiovascular translational research\| PubMed ID: 25931307	2015
Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation\| PubMed ID: 25986447	2015
MetaDiff: differential isoform expression analysis using random-effects meta-regression. BMC bioinformatics\| PubMed ID: 26134005	2015
Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure. Journal of cardiac failure\| PubMed ID: 26209004	2016
Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. Journal of the American Heart Association\| PubMed ID: 26316524	2015
Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”. Circulation. Heart failure\| PubMed ID: 26405727	2015
Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability. Nature communications\| PubMed ID: 26456756	2015
Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart. Physiological reports\| PubMed ID: 26486160	2015
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation\| PubMed ID: 26819374	2016
Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35. The American journal of cardiology\| PubMed ID: 26899490	2016
Mitochondrial protein hyperacetylation in the failing heart. JCI insight\| PubMed ID: 26998524	2016
Comparing Raman and fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe. Journal of biophotonics\| PubMed ID: 27003796	2016
Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science (New York, N.Y.)\| PubMed ID: 27102488	2016
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. PLoS genetics\| PubMed ID: 27149122	2016
Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure. JACC. Heart failure\| PubMed ID: 27179826	2016
Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure. Circulation. Heart failure\| PubMed ID: 27301468	2016
Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury. Diabetes\| PubMed ID: 27335231	2016
Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 27469015	2017
Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. JAMA\| PubMed ID: 27483064	2016
Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites. The American journal of cardiology\| PubMed ID: 27742422	2016
Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites. Journal of the American Heart Association\| PubMed ID: 27742619	2016
Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial. Circulation research\| PubMed ID: 27856497	2017
Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circulation research\| PubMed ID: 27927683	2017
Lack of Benefit for Liraglutide in Heart Failure-Reply. JAMA\| PubMed ID: 27959992	2016
Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations With Ejection Fraction Decline, Recovery, and Heart Failure Symptoms Over 3 Years of Follow-Up. Circulation\| PubMed ID: 28104715	2017
Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 28130335	2017
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nature medicine\| PubMed ID: 28191886	2017
Cytomegalovirus-Responsive CD8 T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 28199780	2017
Low ejection fraction in donor hearts is not directly associated with increased recipient mortality. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 28314504	2017
Effects of organic and inorganic nitrate on aortic and carotid haemodynamics in heart failure with preserved ejection fraction. European journal of heart failure\| PubMed ID: 28547861	2017
Myocardial apoptosis and mesenchymal stem cells with acute exercise. Physiological reports\| PubMed ID: 28576853	2017
Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial. JAMA cardiology\| PubMed ID: 28700781	2017
In vivo label-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system. Scientific reports\| PubMed ID: 28827758	2017
Mechanically dynamic PDMS substrates to investigate changing cell environments. Biomaterials\| PubMed ID: 28843064	2017
Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association\| PubMed ID: 28882819	2017
Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure. The American journal of cardiology\| PubMed ID: 28947307	2017
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia. PloS one\| PubMed ID: 29023576	2017
Right Ventricular Myofilament Functional Differences in Humans With Systemic Sclerosis-Associated Versus Idiopathic Pulmonary Arterial Hypertension. Circulation\| PubMed ID: 29352073	2018
Sparse simultaneous signal detection for identifying genetically controlled disease genes. Journal of the American Statistical Association\| PubMed ID: 29375169	2017
GLP-1 Receptor Expression Within the Human Heart. Endocrinology\| PubMed ID: 29444223	2018
A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. The Journal of clinical investigation\| PubMed ID: 29457789	2018
Determinants of Diuretic Responsiveness and Associated Outcomes During Acute Heart Failure Hospitalization: An Analysis From the NHLBI Heart Failure Network Clinical Trials. Journal of cardiac failure\| PubMed ID: 29482026	2018
Predicting Long Term Outcome in Patients Treated With Continuous Flow Left Ventricular Assist Device: The Penn-Columbia Risk Score. Journal of the American Heart Association\| PubMed ID: 29514805	2018
Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and precision medicine\| PubMed ID: 29540468	2018
Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection. Transplantation\| PubMed ID: 29570167	2018
A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue. PloS one\| PubMed ID: 29614076	2018
Common Coding Variants in Are Associated With the Nav1.8 Late Current and Cardiac Conduction. Circulation. Genomic and precision medicine\| PubMed ID: 29752399	2018
Multi-ethnic genome-wide association study for atrial fibrillation. Nature genetics\| PubMed ID: 29892015	2018
Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine\| PubMed ID: 29892068	2018
Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model. JACC. Basic to translational science\| PubMed ID: 30062212	2018
Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: insights from the FIGHT trial. ESC heart failure\| PubMed ID: 30120812	2018
Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models. JACC. Basic to translational science\| PubMed ID: 30175274	2018
Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophysical journal\| PubMed ID: 30322798	2018
Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. JAMA\| PubMed ID: 30398602	2018
Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. JCI insight\| PubMed ID: 30762586	2019
C-type natriuretic peptide co-ordinates cardiac structure and function. European heart journal\| PubMed ID: 30903134	2020
Cardioprotective Effects of MTSS1 Enhancer Variants. Circulation\| PubMed ID: 31070942	2019
Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants. Circulation\| PubMed ID: 31216868	2019
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure. Nature communications\| PubMed ID: 31235787	2019
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. The Journal of pathology\| PubMed ID: 31424556	2019
Cardiomyocyte d-dopachrome tautomerase protects against heart failure. JCI insight\| PubMed ID: 31484822	2019
Targeting cardiac fibrosis with engineered T cells. Nature\| PubMed ID: 31511695	2019
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature communications\| PubMed ID: 31586055	2019
Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial. Circulation research\| PubMed ID: 31588864	2019
Long-range enhancer-promoter interactions prevent predisposition to atrial fibrillation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31636200	2019
Author Correction: Targeting cardiac fibrosis with engineered T cells. Nature\| PubMed ID: 31723271	2019
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature communications\| PubMed ID: 31919418	2020
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation\| PubMed ID: 31941365	2020
Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction. Journal of the American College of Cardiology\| PubMed ID: 32192654	2020
Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity. JACC. Basic to translational science\| PubMed ID: 32215346	2020
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure. Circulation\| PubMed ID: 32237898	2020
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circulation research\| PubMed ID: 32272864	2020
Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial. Circulation. Heart failure\| PubMed ID: 32362166	2020
In Situ Immune Profiling of Heart Transplant Biopsies Improves Diagnostic Accuracy and Rejection Risk Stratification. JACC. Basic to translational science\| PubMed ID: 32368693	2020
Transcriptional and Cellular Diversity of the Human Heart. Circulation\| PubMed ID: 32403949	2020
Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure. Circulation\| PubMed ID: 32479196	2020
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype. Circulation research\| PubMed ID: 32529949	2020
A low voltage activated Ca current found in a subset of human ventricular myocytes. Channels (Austin, Tex.)\| PubMed ID: 32684070	2020
Reply: In Situ Immune Profiling Identifies Immune Players Involved in Allograft Rejection: A Call for Precision Medicine. JACC. Basic to translational science\| PubMed ID: 32760861	2020
Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel. Journal of the American College of Cardiology\| PubMed ID: 32762907	2020
Investigating Origins of FLIm Contrast in Atherosclerotic Lesions Using Combined FLIm-Raman Spectroscopy. Frontiers in cardiovascular medicine\| PubMed ID: 32793637	2020
Myocyte-Specific Upregulation of in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis. Circulation\| PubMed ID: 32795091	2020
Assigning Distal Genomic Enhancers to Cardiac Disease-Causing Genes. Circulation\| PubMed ID: 32866060	2020
Exogenous ketones in the healthy heart: the plot thickens. Cardiovascular research\| PubMed ID: 33070197	2021
Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure]): Medium-Term and Primary End Point Results. Circulation\| PubMed ID: 33100036	2020
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction. Circulation\| PubMed ID: 33118835	2021
Noncanonical WNT Activation in Human Right Ventricular Heart Failure. Frontiers in cardiovascular medicine\| PubMed ID: 33134326	2020
Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation. Circulation. Genomic and precision medicine\| PubMed ID: 33155827	2020
Label-Free Visualization and Quantification of Biochemical Markers of Atherosclerotic Plaque Progression Using Intravascular Fluorescence Lifetime. JACC. Cardiovascular imaging\| PubMed ID: 33221238	2021
The effect of transfusion of blood products on ventricular assist device support outcomes. ESC heart failure\| PubMed ID: 33263224	2020
Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 33301345	2021
Pulmonary artery pulsatility index predicts right ventricular myofilament dysfunction in advanced human heart failure. European journal of heart failure\| PubMed ID: 33347674	2021
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. Circulation. Heart failure\| PubMed ID: 33430601	2021
Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure. Circulation. Genomic and precision medicine\| PubMed ID: 33517678	2021
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell stem cell\| PubMed ID: 33529599	2021
S-Nitrosylation of Histone Deacetylase 2 by Neuronal Nitric Oxide Synthase as a Mechanism of Diastolic Dysfunction. Circulation\| PubMed ID: 33715387	2021
Cardiac retinoic acid levels decline in heart failure. JCI insight\| PubMed ID: 33724958	2021
Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support. Circulation. Heart failure\| PubMed ID: 33813838	2021
Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy. Circulation\| PubMed ID: 33874732	2021
Chronobiology of Natriuretic Peptides and Blood Pressure in Lean and Obese Individuals. Journal of the American College of Cardiology\| PubMed ID: 33958126	2021
An automated computational image analysis pipeline for histological grading of cardiac allograft rejection. European heart journal\| PubMed ID: 33982079	2021
Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism. ESC heart failure\| PubMed ID: 33991175	2021
Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant. Frontiers in immunology\| PubMed ID: 34122420	2021
Coronavirus disease 2019 in heart transplant recipients: Risk factors, immunosuppression, and outcomes. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 34140222	2021
Is it Time for Trials on Preventing Immune-Mediated Myocardial Damage? JACC. Basic to translational science\| PubMed ID: 34222725	2021
The genomics of heart failure: design and rationale of the HERMES consortium. ESC heart failure\| PubMed ID: 34480422	2021
Functional Consequences of Memory Inflation after Solid Organ Transplantation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34551963	2021
Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34551964	2021
Comparison of Exogenous Ketone Administration Versus Dietary Carbohydrate Restriction on Myocardial Glucose Suppression: A Crossover Clinical Trial. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 34675108	2022
Effect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. JAMA cardiology\| PubMed ID: 34730769	2022
Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 34774754	2022
Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography\| PubMed ID: 34798244	2022
Nuclear deformation guides chromatin reorganization in cardiac development and disease. Nature biomedical engineering\| PubMed ID: 34857921	2021
Comprehensive nutrient consumption estimation and metabolic profiling during ketogenic diet and relationship with myocardial glucose uptake on FDG-PET. European heart journal. Cardiovascular Imaging\| PubMed ID: 35366303	2022
Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy. Circulation\| PubMed ID: 35405081	2022
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis. JACC. Basic to translational science\| PubMed ID: 35411325	2022
How to Apply Translational Models to Probe Mechanisms of Cardiotoxicity. JACC. CardioOncology\| PubMed ID: 35492822	2022
Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy. Circulation. Heart failure\| PubMed ID: 35543134	2022
Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF. Circulation\| PubMed ID: 35603596	2022
Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation\| PubMed ID: 35605036	2022
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature\| PubMed ID: 35732739	2022
Safety and Effectiveness of Intravenous Iron Therapy in Patients Supported by Durable Left Ventricular Assist Devices. Journal of clinical medicine\| PubMed ID: 35807184	2022
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment. Molecular therapy. Methods & clinical development\| PubMed ID: 35818571	2022
CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia. Frontiers in immunology\| PubMed ID: 35837398	2022
Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission. Biomaterials\| PubMed ID: 35953331	2022
The Anemia Stress Index-Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices. Journal of clinical medicine\| PubMed ID: 35956132	2022
Glutamine uptake and catabolism is required for myofibroblast formation and persistence. Journal of molecular and cellular cardiology\| PubMed ID: 35988357	2022
Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms. Basic research in cardiology\| PubMed ID: 36006489	2022
DELIVERing Progress in Heart Failure with Preserved Ejection Fraction. The New England journal of medicine\| PubMed ID: 36027566	2022
Genome-wide fetalization of enhancer architecture in heart disease. Cell reports\| PubMed ID: 36130500	2022
Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 36172868	2022
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell metabolism\| PubMed ID: 36223763	2022
Noncanonical Form of ERAD Regulates Cardiac Hypertrophy. Circulation\| PubMed ID: 36317534	2023
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure. Nature communications\| PubMed ID: 36376295	2022
Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nature cardiovascular research\| PubMed ID: 36776621	2022
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure. Cell reports\| PubMed ID: 36790929	2023
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation\| PubMed ID: 36856044	2023
Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity. Cell metabolism\| PubMed ID: 36868222	2023
The evolving use of biomarkers in heart transplantation: Consensus of an expert panel. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 36870390	2023
Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload. Journal of cardiovascular translational research\| PubMed ID: 36877449	2023
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury. JACC. Basic to translational science\| PubMed ID: 37034289	2023
Med25 Limits Master Regulators That Govern Adipogenesis. International journal of molecular sciences\| PubMed ID: 37047128	2023
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension. Circulation\| PubMed ID: 37194598	2023
Tissue Rings PLOD Out a Second Hit in Becker Muscular Dystrophy. JACC. Basic to translational science\| PubMed ID: 37426536	2023
Adult human cardiomyocyte mechanics in osteogenesis imperfecta. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 37566108	2023
The HFSA Advanced Heart Failure and Transplant Cardiology Fellowship Consensus Conference. Journal of cardiac failure\| PubMed ID: 37806488	2024
Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans. Nucleic acids research\| PubMed ID: 37843128	2023
Early Increases in Blood Pressure and Major Adverse Cardiovascular Events in Patients With Renal Cell Carcinoma and Thyroid Cancer Treated With VEGFR TKIs. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 37856199	2023
Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. The Journal of clinical investigation\| PubMed ID: 37943622	2024
New Cardiotoxicity Risk Assessment Guidelines: Searching for Validation. JACC. CardioOncology\| PubMed ID: 37969648	2023
Epistasis regulates genetic control of cardiac hypertrophy. Research square\| PubMed ID: 38045390	2023
Failing to Make the Grade: Conventional Cardiac Allograft Rejection Grading Criteria Are Inadequate for Predicting Rejection Severity. Circulation. Heart failure\| PubMed ID: 38348670	2024
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes. Basic research in cardiology\| PubMed ID: 38349539	2024
Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes. JACC. Basic to translational science\| PubMed ID: 38362346	2024
Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to cardiomyopathy. Science advances\| PubMed ID: 38718107	2024
Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Science translational medicine\| PubMed ID: 39018366	2024
Myocardial ultrastructure of human heart failure with preserved ejection fraction. Nature cardiovascular research\| PubMed ID: 39196036	2024
Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program. Nature cardiovascular research\| PubMed ID: 39196175	2024
Pathophysiological insights into HFpEF from studies of human cardiac tissue. Nature reviews. Cardiology\| PubMed ID: 39198624	2025
Endogenous adenine is a potential driver of the cardiovascular-kidney-metabolic syndrome. medRxiv : the preprint server for health sciences\| PubMed ID: 39228698	2024
Virally delivered CMYA5 enhances the assembly of cardiac dyads. Nature biomedical engineering\| PubMed ID: 39237710	2024
Cardiac NAD depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nature cardiovascular research\| PubMed ID: 39294272	2024
Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction. Circulation. Heart failure\| PubMed ID: 39421941	2024
Unipolar Voltage Mapping to Predict Recovery of Left Ventricular Ejection Fraction in Patients With Recent-Onset Nonischemic Cardiomyopathy. Circulation\| PubMed ID: 39540275	2025
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation. Nature communications\| PubMed ID: 39562555	2024
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. Nature genetics\| PubMed ID: 39572783	2024
Atrial Fibrillation in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy: Real-World Incidence, Management, and Outcomes. JACC. Clinical electrophysiology\| PubMed ID: 39641697	2025
Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA cardiology\| PubMed ID: 39693096	2025
Clinical studies in Myxomatous Mitral Valve Disease dogs: most prescribed ACEI inhibits ACE2 enzyme activity and ARB increases AngII pool in plasma. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 39837966	2025
Evaluation of Biologics ACE2/Ang(1-7) Encapsulated in Plant Cells for FDA Approval: Safety and Toxicology Studies. Pharmaceutics\| PubMed ID: 39861664	2024
Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling. The Journal of clinical investigation\| PubMed ID: 39932799	2025
Correction: Clinical studies in Myxomatous Mitral Valve Disease dogs: most prescribed ACEI inhibits ACE2 enzyme activity and ARB increases AngII pool in plasma. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 39953241	2025
Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure. bioRxiv : the preprint server for biology\| PubMed ID: 39975328	2025
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nature genetics\| PubMed ID: 40038546	2025
Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac r... Clinical epigenetics\| PubMed ID: 40057770	2025
Precision Medicine Is in the Eye of the Beholder. Circulation. Heart failure\| PubMed ID: 40066597	2025
Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF. JACC. Basic to translational science\| PubMed ID: 40139871	2025
Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation. JHLT open\| PubMed ID: 40144822	2025
Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction. JACC. Heart failure\| PubMed ID: 40243975	2025
Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction. Cell metabolism\| PubMed ID: 40267914	2025
Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy. Circulation. Heart failure\| PubMed ID: 40391807	2025
Epistasis regulates genetic control of cardiac hypertrophy. Nature cardiovascular research\| PubMed ID: 40473955	2025