Anne-Marie Malfait

Department of Internal Medicine, Rush University Medical Center

Affiliated withRush University Medical Center Chicago Center on Musculoskeletal Pain

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2025

Other Publications

Article	Year
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Archives of biochemistry and biophysics\| PubMed ID: 20447377	2010
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21337391	2011
Modelling pain in post-traumatic osteoarthritis of the knee. Pain\| PubMed ID: 22018974	2012
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Annals of the rheumatic diseases\| PubMed ID: 22440827	2012
Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis and rheumatism\| PubMed ID: 22492243	2012
Nanoparticles for improved local retention after intra-articular injection into the knee joint. Pharmaceutical research\| PubMed ID: 22996566	2013
CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23185004	2012
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Current rheumatology reports\| PubMed ID: 23926636	2013
A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and cartilage\| PubMed ID: 23973146	2013
Towards a mechanism-based approach to pain management in osteoarthritis. Nature reviews. Rheumatology\| PubMed ID: 24045707	2013
Osteoarthritis joint pain: the cytokine connection. Cytokine\| PubMed ID: 25066335	2014
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis and cartilage\| PubMed ID: 25800415	2015
The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain. Current osteoporosis reports\| PubMed ID: 26233284	2015
Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 26245312	2015
PCSK6-mediated corin activation is essential for normal blood pressure. Nature medicine\| PubMed ID: 26259032	2015
On the predictive utility of animal models of osteoarthritis. Arthritis research & therapy\| PubMed ID: 26364707	2015
Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. Osteoarthritis and cartilage\| PubMed ID: 26410555	2016
Osteoarthritis year in review 2015: biology. Osteoarthritis and cartilage\| PubMed ID: 26707989	2016
Spinal microglial activation in a murine surgical model of knee osteoarthritis. Osteoarthritis and cartilage\| PubMed ID: 27646532	2017
Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Current opinion in rheumatology\| PubMed ID: 27672741	2017
Emerging Targets for the Management of Osteoarthritis Pain. Current osteoporosis reports\| PubMed ID: 27730452	2016
Can we target CCR2 to treat osteoarthritis? The trick is in the timing! Osteoarthritis and cartilage\| PubMed ID: 28189827	2017
Time to be positive about negative data? Osteoarthritis and cartilage\| PubMed ID: 28224967	2017
Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 28380690	2017
Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 28767178	2018
Development of a Cartilage Shear-Damage Model to Investigate the Impact of Surface Injury on Chondrocytes and Extracellular Matrix Wear. Cartilage\| PubMed ID: 28934882	2017
Why we should study pain in animal models of rheumatic diseases. Clinical and experimental rheumatology\| PubMed ID: 28967366	2017
Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain. Clinical and experimental rheumatology\| PubMed ID: 28967370	2017
Pain in rheumatic diseases. Clinical and experimental rheumatology\| PubMed ID: 28967375	2017
Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 28992367	2018
What is new in pain modification in osteoarthritis? Rheumatology (Oxford, England)\| PubMed ID: 29361112	2018
Peripheral Mechanisms Contributing to Osteoarthritis Pain. Current rheumatology reports\| PubMed ID: 29480410	2018
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI insight\| PubMed ID: 29563338	2018
Osteoarthritis pain: What are we learning from animal models? Best practice & research. Clinical rheumatology\| PubMed ID: 30509413	2017
Disease Burden in Osteoarthritis Is Similar to That of Rheumatoid Arthritis at Initial Rheumatology Visit and Significantly Greater Six Months Later. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 30891933	2019
The nociceptive innervation of the normal and osteoarthritic mouse knee. Osteoarthritis and cartilage\| PubMed ID: 31351964	2019
An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis. Seminars in immunopathology\| PubMed ID: 31612243	2019
New concepts in osteoarthritis. Clinical and experimental rheumatology\| PubMed ID: 31621567	2019
The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic. Clinical and experimental rheumatology\| PubMed ID: 31621572	2019
The innate immune response as a mediator of osteoarthritis pain. Osteoarthritis and cartilage\| PubMed ID: 31862470	2020
Why we should study osteoarthritis pain in experimental models in both sexes. Osteoarthritis and cartilage\| PubMed ID: 31926266	2020
Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis. Osteoarthritis and cartilage\| PubMed ID: 31982564	2020
Targeting neurotrophic factors: Novel approaches to musculoskeletal pain. Pharmacology & therapeutics\| PubMed ID: 32311372	2020
Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome. Pain\| PubMed ID: 32483055	2020
Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives. Rheumatic diseases clinics of North America\| PubMed ID: 33781488	2021
The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice. Arthritis research & therapy\| PubMed ID: 33827672	2021
Neuroimmune interactions and osteoarthritis pain: focus on macrophages. Pain reports\| PubMed ID: 33981927	2021
Can we prevent chronic osteoarthritis pain? A view from the bench. Osteoarthritis and cartilage\| PubMed ID: 34628019	2021
Animal Models of Ehlers-Danlos Syndromes: Phenotype, Pathogenesis, and Translational Potential. Frontiers in genetics\| PubMed ID: 34712265	2021
Pain in the Ehlers-Danlos syndromes: Mechanisms, models, and challenges. American journal of medical genetics. Part C, Seminars in medical genetics\| PubMed ID: 34797601	2021
The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain. Clinics in geriatric medicine\| PubMed ID: 35410677	2022
Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation. medRxiv : the preprint server for health sciences\| PubMed ID: 36865307	2023
Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain. Arthritis research & therapy\| PubMed ID: 37061736	2023
Age-Associated Changes in Knee Osteoarthritis, Pain-Related Behaviors, and Dorsal Root Ganglia Immunophenotyping of Male and Female Mice. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 37096632	2023
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. Nature communications\| PubMed ID: 37120427	2023
Sensory Profiling in Classical Ehlers-Danlos Syndrome: A Case-Control Study Revealing Pain Characteristics, Somatosensory Changes, and Impaired Pain Modulation. The journal of pain\| PubMed ID: 37380025	2023
Analysis of matrisome expression patterns in murine and human dorsal root ganglia. Frontiers in molecular neuroscience\| PubMed ID: 37664243	2023
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis. Science translational medicine\| PubMed ID: 38598614	2024
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression. Molecular pain\| PubMed ID: 38752471	2024
A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis and cartilage\| PubMed ID: 38823432	2024
Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee. bioRxiv : the preprint server for biology\| PubMed ID: 38853939	2024
36-40% of Routine Care Patients With Osteoarthritis or Rheumatoid Arthritis Screen Positive for Anxiety, Depression, and/or Fibromyalgia on a Single MDHAQ. ACR open rheumatology\| PubMed ID: 39011669	2024
Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models. Frontiers in neuroanatomy\| PubMed ID: 39076825	2024
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage. bioRxiv : the preprint server for biology\| PubMed ID: 39229102	2024
Unmet Needs in Spondyloarthritis: Understanding and Managing Chronic Pain. The Journal of rheumatology\| PubMed ID: 39448250	2024
Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 39547819	2025
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage. Arthritis research & therapy\| PubMed ID: 39707543	2024
Osteoarthritis. Nature reviews. Disease primers\| PubMed ID: 39948092	2025
Mechanisms of joint pain: Five short lessons from osteoarthritis. Seminars in arthritis and rheumatism\| PubMed ID: 40024857	2025
FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes. bioRxiv : the preprint server for biology\| PubMed ID: 40166233	2025
Targeting osteoarthritis where it hurts: the osteochondral junction. Nature reviews. Rheumatology\| PubMed ID: 40263460	2025
Prevalence of Pain and Factors Associated with Pain in Patients with Idiopathic Inflammatory Myopathies. Arthritis care & research\| PubMed ID: 40356255	2025