endoscopic-ultrasound-based-differentiation-pancreatic-neuroendocrine

Endoscopic Ultrasound-Based Differentiation of Pancreatic Neuroendocrine Tumors and Pancreatic Duct Adenocarcinoma

Endoscopic ultrasound (EUS) is one of the most critical imaging modalities for evaluating pancreatic masses, providing high-resolution visualization of ...

structured-approach-to-colonoscopy-technique-optimization-single

Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists

A colonoscope is a vital instrument used in performing colonoscopies, with the goal of identifying pathology such as ulcers, inflammation, polyps, and ...

Fudan University

Shanghai Jiaotong University

Minhang Hospital of Fudan University

Metabolome profiles are largely unknown for pancreatic head cancers, in which the predominant anatomical feature is the exosure of bile, pancreatic juice, and duodenal juice. In this research, 30 head and 30 body/tail cytological samples acquired by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of pancreatic adenocarcinoma were delivered for liquid chromatography coupled with mass spectrometry (LC-MS). Transcriptome analysis was performed using the sequencing data from The Cancer Genome Atlas (TCGA) cohort. LC-MS obtained 4,857 features in EUS-FNA cytological samples, and 586 metabolites were certified. Among them, 30 differential metabolites were identified. In the TCGA cohort, 247 differential metabolism genes were selected from 1,583 differential genes. The integrated analysis identified the top three enriched metabolic pathways as follows: branched chain amino acid (BCAA) biosynthesis; glycerophospholipid metabolism; and phenylalanine metabolism. In cell line, BCAA promoted pancreatic cancer proliferation and inhibited Oxaliplatin-induced apoptosis. In conclusion, metabolomic analysis with the EUS-FNA sample is feasible for pancreatic cancer. The integrated analysis can identify key metabolites and enzyme-coded genes between pancreatic head and body/tail adenocarcinoma. Anti-BCAA metabolism therapy may exert promising effect, especially for the body/tail cancer.

Integrated analysis of metabolome in a EUS-FNA sample with transcriptome in the TCGA cohort of pancreatic head and body/tail adenocarcinoma.

The prognostic nutritional index (PNI) is a useful tool to evaluate nutritional status, which is associated with postoperative complications and prognosis of patients with cancer. Recent studies have shown that PNI has important predictive value for postoperative infection in cancer patients. However, the role and clinical value of PNI in infection after radical gastrectomy remains unclear. This study investigated the relationship between PNI and infection after radical surgery for gastric cancer (GC), focusing on the predictive value of PNI.

ArticleTotal : 2	Year
Publication title	2025
Publication title Cited by 1	2025

Article	Year
Integrated analysis of metabolome in a EUS-FNA sample with transcriptome in the TCGA cohort of pancreatic head and body/tail adenocarcinoma. Aging\| PubMed ID: 33714949	2021
Predictive value of prognostic nutritional index on infection after radical gastrectomy: a retrospective study. Journal of gastrointestinal oncology\| PubMed ID: 35557565	2022

Danjie Shen

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