intrahepatic-cholangiolithiasis-extraction-during-endoscopic

Intrahepatic Cholangiolithiasis Extraction During Endoscopic Retrograde Cholangiopancreatography Using a Disposable Ultrafine Peroral Cholangioscope

Hepatolithiasis refers to the presence of stones in the branching bile ducts above the confluence of the left and right hepatic ducts, often accompanied ...

a-single-center-study-efficacy-safety-assessment-ercp-elderly

A Single Center Study of Efficacy and Safety Assessment of ERCP in Elderly Patients

Endoscopic retrograde cholangiopancreatography (ERCP) has emerged as a valuable minimally invasive therapeutic method for pancreatobiliary diseases and is ...

Shanghai Jiao Tong University School of Medicine

Colorectal cancer (CRC) is the most common malignancy worldwide, and its underlying molecular mechanisms remain largely unexplored. Accumulating evidences indicate cancer-associated fibroblasts (CAFs), abundant stromal cell population in the tumor microenvironment, play a key role in tumor development. Herein, we have successfully isolated CAFs and paired normal fibroblasts (NFs) from colorectal cancer tissues (n=10). By using a multiplex cytokine profiling assay, we have identified IL-6 as a major cytokine released by CAFs. Co-culturing of CAFs with CRC cell lines HCT116 or SW480 increases IL-6 release, and the secretion by CAFs can be further enhanced under hypoxia. By using the CCK-8 assay, we have found that HCT116 or SW480 cells treated with culture medium from CAFs, IL-6, or hypoxia showed a significant cell growth compared to control cells (p<0.01). Mechanistically, we have found that hypoxia could enhance the effect of the IL-6/STAT3 signaling on CRC cells, in part, through HIF-1a targeting PKM2. In conclusion, our data clearly proposes the interconnected mechanisms for constitutive activation of STAT3 signal by CAFs-derived IL-6 under hypoxia in colorectal cancer. The pharmacological inhibition of STAT3, PKM2, or HIF-1α can significantly reduce the oncogenic effect of IL-6, providing a potential therapeutic target for CRC patients.

Hypoxia facilitates the proliferation of colorectal cancer cells by inducing cancer-associated fibroblast-derived IL6.

Accumulating data support that regular physical activity potentially inhibits chronic colitis, a risk factor for colitis-associated cancer (CAC). However, possible effects of physical activity on CAC and the underlying mechanisms remain poorly understood.

Swimming Impedes Intestinal Microbiota and Lipid Metabolites of Tumorigenesis in Colitis-Associated Cancer.

Gallstone disease (GSD) is a major public health problem worldwide. The dietary inflammatory index (DII) and the energy-adjusted DII (E-DII) have been used to describe dietary inflammatory potential. The current study sought to investigate the pro-inflammatory role of diet on GSD among outpatients in the United States.

Association of pro-inflammatory diet with increased risk of gallstone disease: a cross-sectional study of NHANES January 2017-March 2020.

Nearly half of patients with diabetes experience diabetic peripheral neuropathy (DPN), resulting in a mere 53% survival rate within 3 years. Aberrations in coagulation function have been implicated in the pathogenesis of microvascular complications, prompting the need for a thorough investigation into its role as a contributing factor in the development and progression of DPN.

Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes.

The arterial blood gas (ABG) reference values determined at or near sea level may not be applicable in high-altitude areas. This study investigated the reference values of the ABG indexes for adult respiratory failure in the Tibetan Autonomous Prefecture in Yunnan Province, China. This prospective study enrolled adult patients with respiratory failure at the internal medicine department of Diqing Tibetan Autonomous Prefecture (altitude: 3294 m) in Yunnan province between November 2019 and March 2022. There were 112 cases of type I respiratory failure (median age of 56 years, 61 males) and 91 with type II respiratory failure (median age of 59 years, 42 males). The reference value of PaO for type I respiratory failure was 46.9 mmHg (AUC 1.000, 95% CI 1.000-1.000, sensitivity and specificity of 100%, P < 0.001). The reference value of PaCO for type II respiratory failure was 38.1 mmHg (AUC 0.871, 95% CI 0.823-0.920, sensitivity and specificity of 95.6% and 60.4%, respectively, P < 0.001). It might be recommended that the reference values of PaO and PaCO for type I and II respiratory failure be 46.9 and 38.1 mmHg, respectively, in high-altitude areas.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Article	Year
Hypoxia facilitates the proliferation of colorectal cancer cells by inducing cancer-associated fibroblast-derived IL6. Neoplasma\| PubMed ID: 34374296	2021
Swimming Impedes Intestinal Microbiota and Lipid Metabolites of Tumorigenesis in Colitis-Associated Cancer. Frontiers in oncology\| PubMed ID: 35847876	2022
Association of pro-inflammatory diet with increased risk of gallstone disease: a cross-sectional study of NHANES January 2017-March 2020. Frontiers in nutrition\| PubMed ID: 38549748	2024
Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes. CNS neuroscience & therapeutics\| PubMed ID: 39258827	2024
Reference values of arterial blood gas index in adult respiratory failure in high altitude area. Scientific reports\| PubMed ID: 40348814	2025

Haiqin Zhang

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