in-vivo-glioblastoma-tumor-modeling-via-stereotaxic-injection-mice

<em>In Vivo</em> Glioblastoma Tumor Modeling via Stereotaxic Injection in Mice for Tumor Progression Studies

Glioblastoma (GB) is a highly aggressive brain cancer with a median survival of under 2 years despite conventional therapy. Research efforts frequently ...

Brain Health and Metabolism (GERO)

Universidad San Sebastián

LOX rises as a potential survival biomarker: A commentary on "Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme" by Liu et al.

The tumor microenvironment (TME) represents a dynamic network of cancer cells, stromal cells, immune mediators, and extracellular matrix components, crucial for cancer progression. Stress conditions such as oncogene activation, nutrient deprivation, and hypoxia disrupt the endoplasmic reticulum (ER), activating the unfolded protein response (UPR), the main adaptive mechanism to restore ER function. The UPR regulates cancer progression by engaging cell-autonomous and cell-non-autonomous mechanisms, reprogramming the stroma and promoting immune evasion, angiogenesis, and invasion. This review explores the role of UPR beyond cancer cells, focusing on how ER stress signaling reshapes the TME, supporting tumor growth. The therapeutic potential of targeting the UPR is also discussed.

Article	Year
LOX rises as a potential survival biomarker: A commentary on "Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme" by Liu et al. Translational oncology\| PubMed ID: 38641375	2024
The UPRising connection between endoplasmic reticulum stress and the tumor microenvironment. Trends in cancer\| PubMed ID: 39472237	2024

Hery Urra

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