Jiangping Xu

NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University

Affiliated withSouthern Medical University

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
[Fingerprinting of Panax notoginseng by high-performance liquid chromatography]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA\| PubMed ID: 15604072	2004
Effects of timosaponins on learning and memory abilities of rats with dementia induced by lateral cerebral ventricular injection of amyloid beta- peptide. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA\| PubMed ID: 15698986	2005
[General pharmacology of Danhong injection]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA\| PubMed ID: 15772007	2005
[Preparation of anti-morphine monoclonal antibodies with complete cross reactivity with heroin]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA\| PubMed ID: 16027080	2005
[Determination of organochlorine pesticide residue in nine Chinese herbs by gas chromatography]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 16495190	2006
Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain research\| PubMed ID: 16870162	2006
[Construction and screening of plasmid expression vectors encoding the short hairpin RNA targeting hVEGF(165) gene]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 18227020	2008
[Effect of nattokinase on restenosis after percutaneous transluminal angioplasty of the abdominal artery in rabbits]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 18819862	2008
[Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials\| PubMed ID: 19230404	2008
Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer's disease. Psychopharmacology\| PubMed ID: 19263040	2009
Antidepressant effect of the extracts from Fructus Akebiae. Pharmacology, biochemistry, and behavior\| PubMed ID: 19931301	2010
[Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 20501389	2010
Pharmacokinetics and pharmacodynamics of subcutaneous injection and intravenous infusion of recombinant human interleukin-12 and recombinant human interleukin-12 combined with hepatitis B su... Pharmacology\| PubMed ID: 20516733	2010
Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats. Psychopharmacology\| PubMed ID: 20640406	2010
Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats. Metabolic brain disease\| PubMed ID: 21327879	2011
Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography-tandem mass spectrometry method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 21680262	2011
The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. The international journal of neuropsychopharmacology\| PubMed ID: 21733236	2012
The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor. Pharmacology, biochemistry, and behavior\| PubMed ID: 22005599	2012
[Effects of piperphentonamine hydrochloride on cognitive deficits in rats induced by cerebral ischemia-reperfusion]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 22126765	2011
Promotion of β-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease. Neurochemistry international\| PubMed ID: 22202667	2012
Piperphentonamine (PPTA) attenuated cerebral ischemia-induced memory deficits via neuroprotection associated with anti-apoptotic activity. Metabolic brain disease\| PubMed ID: 22843383	2012
Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 23624119	2013
Systematic correlation between spine plasticity and the anxiety/depression-like phenotype induced by corticosterone in mice. Neuroreport\| PubMed ID: 23839258	2013
RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in mice. Journal of Alzheimer's disease : JAD\| PubMed ID: 23948935	2014
Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes. Journal of physiology and biochemistry\| PubMed ID: 24078284	2014
Chlorbipram: a novel PDE4 inhibitor with improved safety as a potential antidepressant and cognitive enhancer. European journal of pharmacology\| PubMed ID: 24113523	2013
Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder. The international journal of neuropsychopharmacology\| PubMed ID: 24763106	2014
The nerve growth factor signaling and its potential as therapeutic target for glaucoma. BioMed research international\| PubMed ID: 25250333	2014
Synthesis and anticancer activities of 3-arylflavone-8-acetic acid derivatives. European journal of medicinal chemistry\| PubMed ID: 25461325	2015
Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression. Pharmaceutical biology\| PubMed ID: 25471378	2015
Neuroprotection, learning and memory improvement of a standardized extract from Renshen Shouwu against neuronal injury and vascular dementia in rats with brain ischemia. Journal of ethnopharmacology\| PubMed ID: 25704930	2015
C-Reactive Protein Induces Tau Hyperphosphorylation via GSK3β Signaling Pathway in SH-SY5Y Cells. Journal of molecular neuroscience : MN\| PubMed ID: 25966642	2015
Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease. Molecular neurodegeneration\| PubMed ID: 26013581	2015
The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2. Journal of physiology and biochemistry\| PubMed ID: 26271386	2015
Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology\| PubMed ID: 26279492	2015
Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC complementary and alternative medicine\| PubMed ID: 26497584	2015
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. Bioorganic & medicinal chemistry\| PubMed ID: 26526739	2015
Determination of a novel phosphodiesterase-4 inhibitor chlorbipram in mouse plasma and brain by UFLC-MS/MS: Application in pharmacokinetic studies after intravenous administration. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 26571454	2015
ASIC subunit ratio and differential surface trafficking in the brain. Molecular brain\| PubMed ID: 26746198	2016
cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats. Neuropsychiatric disease and treatment\| PubMed ID: 26855578	2016
Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Scientific reports\| PubMed ID: 26879043	2016
Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25-35 in rats. Metabolic brain disease\| PubMed ID: 26920899	2016
Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2. Frontiers in cellular neuroscience\| PubMed ID: 27242438	2016
Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells. Journal of molecular neuroscience : MN\| PubMed ID: 27412469	2016
Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing arom... European journal of medicinal chemistry\| PubMed ID: 27597413	2016
Discovery of N-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses. ACS chemical neuroscience\| PubMed ID: 27690383	2017
FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects. Neuropharmacology\| PubMed ID: 28065587	2017
[Role of cAMP/CREB/BDNF signaling pathway in anti-depressive effect of vortioxetine in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 28109109	2017
Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage. ACS chemical neuroscience\| PubMed ID: 28447781	2017
Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-B Inhibition. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 28450469	2017
Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS chemical neuroscience\| PubMed ID: 28605578	2017
Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 28650427	2017
Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacology\| PubMed ID: 28748375	2017
Discovery of 9H-purins as potential tubulin polymerization inhibitors: Synthesis, biological evaluation and structure-activity relationships. European journal of medicinal chemistry\| PubMed ID: 28763647	2017
FOXO Signaling Pathways as Therapeutic Targets in Cancer. International journal of biological sciences\| PubMed ID: 28808415	2017
The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget\| PubMed ID: 28881851	2017
Dysbindin-1 Involvement in the Etiology of Schizophrenia. International journal of molecular sciences\| PubMed ID: 28937620	2017
Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities. European journal of medicinal chemistry\| PubMed ID: 29040954	2017
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain research bulletin\| PubMed ID: 29155261	2018
Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways. International journal of molecular sciences\| PubMed ID: 29419799	2018
Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29447005	2018
Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP-induced decline of mitochondrial membrane potential and oxidative stress. Redox biology\| PubMed ID: 29475134	2018
cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia. Frontiers in molecular neuroscience\| PubMed ID: 30214393	2018
Mechanisms underlying the rapid-acting antidepressant-like effects of neuropeptide VGF (non-acronymic) C-terminal peptide TLQP-62. Neuropharmacology\| PubMed ID: 30291938	2018
Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus sp. SCSIOS02F49. Molecules (Basel, Switzerland)\| PubMed ID: 30388842	2018
FCPR16, a novel phosphodiesterase 4 inhibitor, produces an antidepressant-like effect in mice exposed to chronic unpredictable mild stress. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 30391306	2019
Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Prevents Dendritic Spine Loss in Mice Hippocampi. The international journal of neuropsychopharmacology\| PubMed ID: 30407503	2019
Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke. International journal of biological sciences\| PubMed ID: 30416389	2018
A new polyhydroxylated oleanane triterpenoid from the roots of . Natural product research\| PubMed ID: 30580617	2020
Discovery of 2-(3,4-dialkoxyphenyl)-2-(substituted pyridazin-3-yl)acetonitriles as phosphodiesterase 4 inhibitors with anti-neuroinflammation potential based on three-dimensional quantitativ... Chemical biology & drug design\| PubMed ID: 30588755	2019
FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway. Biochemical pharmacology\| PubMed ID: 30797872	2019
Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP-induced oxidative insult. Free radical biology & medicine\| PubMed ID: 30818055	2019
Discovery of arylbenzylamines as PDE4 inhibitors with potential neuroprotective effect. European journal of medicinal chemistry\| PubMed ID: 30822711	2019
Chronic unpredictable mild stress induced depression-like behaviours and glutamate-glutamine cycling dysfunctions in both blood and brain of mice. Pharmaceutical biology\| PubMed ID: 30990732	2019
Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway. Redox biology\| PubMed ID: 31639651	2020
Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells. Cellular and molecular neurobiology\| PubMed ID: 31659561	2020
Protective effect of gui zhi (Ramulus Cinnamomi) on abnormal levels of four amino acid neurotransmitters by chronically ma huang (Herb Ephedra) intoxicated prefrontal cortex in rats treated ... Journal of ethnopharmacology\| PubMed ID: 31751653	2020
Crystal structures, dissolution and pharmacokinetic study on a novel phosphodiesterase-4 inhibitor chlorbipram cocrystals. International journal of pharmaceutics\| PubMed ID: 31870960	2020
Roflupram exerts neuroprotection via activation of CREB/PGC-1α signalling in experimental models of Parkinson's disease. British journal of pharmacology\| PubMed ID: 31972868	2020
Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function. Frontiers in pharmacology\| PubMed ID: 32695005	2020
Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin. ACS medicinal chemistry letters\| PubMed ID: 32832031	2020
Reciprocal Substitution Between Methamphetamine and Heroin in Terms of Reinforcement Effects in Rats. Frontiers in psychiatry\| PubMed ID: 32848928	2020
Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons. Oxidative medicine and cellular longevity\| PubMed ID: 32849999	2020
Acute EPA-induced learning and memory impairment in mice is prevented by DHA. Nature communications\| PubMed ID: 33122660	2020
Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress. Brain, behavior, and immunity\| PubMed ID: 33221489	2021
Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. International immunopharmacology\| PubMed ID: 33243606	2021
AMI, an Indazole Derivative, Improves Parkinson's Disease by Inhibiting Tau Phosphorylation. Frontiers in molecular neuroscience\| PubMed ID: 33328879	2020
Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway. Free radical biology & medicine\| PubMed ID: 33359910	2021
Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients. Aging and disease\| PubMed ID: 34094643	2021
Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells. European journal of medicinal chemistry\| PubMed ID: 34311158	2021
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis. Clinical science (London, England : 1979)\| PubMed ID: 34318888	2021
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models. Acta pharmacologica Sinica\| PubMed ID: 34531546	2021
Hederagenin Protects PC12 Cells Against Corticosterone-Induced Injury by the Activation of the PI3K/AKT Pathway. Frontiers in pharmacology\| PubMed ID: 34721013	2021
MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway. Annals of translational medicine\| PubMed ID: 34790800	2021
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. Frontiers in immunology\| PubMed ID: 34925379	2021
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein. Toxicology and applied pharmacology\| PubMed ID: 34990728	2022
Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments. ACS chemical neuroscience\| PubMed ID: 35050567	2022
The Regulation of Glutamate Transporter 1 in the Rapid Antidepressant-Like Effect of Ketamine in Mice. Frontiers in behavioral neuroscience\| PubMed ID: 35309681	2022
Intracellular Activity of Poly (DL-Lactide-co-Glycolide) Nanoparticles Encapsulated with Prothionamide, Pyrazinamide, Levofloxacin, Linezolid, or Ethambutol on Multidrug-Resistant . Current drug delivery\| PubMed ID: 35546770	2023
Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 path... European journal of pharmacology\| PubMed ID: 35569548	2022
Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice. Chinese medicine\| PubMed ID: 35668445	2022
Mitofusin 2 confers the suppression of microglial activation by cannabidiol: Insights from in vitro and in vivo models. Brain, behavior, and immunity\| PubMed ID: 35688339	2022
Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease. European journal of medicinal chemistry\| PubMed ID: 35689855	2022
Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data. Frontiers in genetics\| PubMed ID: 35711916	2022
QEEG indices are associated with inflammatory and metabolic risk factors in Parkinson's disease dementia: An observational study. EClinicalMedicine\| PubMed ID: 36034410	2022
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats. Acta pharmacologica Sinica\| PubMed ID: 36229600	2023
MicroRNA-124-3p alleviates cerebral ischaemia-induced neuroaxonal damage by enhancing Nrep expression. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 36535134	2023
Advances in the development of phosphodiesterase 7 inhibitors. European journal of medicinal chemistry\| PubMed ID: 36796299	2023
TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model. Experimental neurology\| PubMed ID: 38056584	2024
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models. Experimental neurology\| PubMed ID: 38104887	2024
Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice. Neuroscience letters\| PubMed ID: 38242347	2024
Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression and astrocyte swelling following cerebral ischemia/reperfusion injury. Glia\| PubMed ID: 38785370	2024
Phelligridimer A enhances the expression of mitofusin 2 and protects against cerebral ischemia/reperfusion injury. Chemico-biological interactions\| PubMed ID: 38825057	2024
Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis. European journal of medicinal chemistry\| PubMed ID: 38861808	2024
Mitofusin 2 Mediates the Protective Effect of NR6A1 Silencing Against Neuronal Injury in Experimental Stroke Models. Molecular neurobiology\| PubMed ID: 39259438	2025
Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion. Molecular neurobiology\| PubMed ID: 39287745	2025
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD. Journal of neuroinflammation\| PubMed ID: 39844196	2025
A novel PDE4 inhibitor ZX21011 alleviates neuronal apoptosis by decreasing GSK3β-mediated Drp1 Ser616 phosphorylation in cerebral ischemia reperfusion. Chemico-biological interactions\| PubMed ID: 39889870	2025
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice. Brain, behavior, and immunity\| PubMed ID: 39947489	2025
Discovery of Limonoids from as Potential Leads against Neuroinflammation. Journal of natural products\| PubMed ID: 40228158	2025
Glial changes and gene expression in Alzheimer's disease from snRNA-Seq and spatial transcriptomics. Journal of Alzheimer's disease : JAD\| PubMed ID: 40267277	2025