Josephine M. Egan

Diabetes Section/Laboratory of Clinical Investigation, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. The American journal of physiology\| PubMed ID: 8572206	1995
Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix. Pancreas\| PubMed ID: 8783333	1996
Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells. Molecular and cellular biology\| PubMed ID: 9891063	1999
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 11861804	2002
The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 11889200	2002
Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism\| PubMed ID: 12161508	2002
Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 12475750	2003
Pharmacological agents that directly modulate insulin secretion. Pharmacological reviews\| PubMed ID: 12615955	2003
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. Journal of neuroscience research\| PubMed ID: 12749025	2003
The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regulatory peptides\| PubMed ID: 12832104	2003
Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15199095	2004
Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Diabetes care\| PubMed ID: 15220248	2004
In vivo biological activity of exendin (1-30). Endocrine\| PubMed ID: 16077164	2005
Peptide YY is secreted after oral glucose administration in a gender-specific manner. The Journal of clinical endocrinology and metabolism\| PubMed ID: 16174724	2005
Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16968811	2007
Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17505054	2007
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17724330	2007
Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study o... Metabolism: clinical and experimental\| PubMed ID: 17884459	2007
Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. Diabetes care\| PubMed ID: 18268070	2008
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287083	2008
Taste cells of the gut and gastrointestinal chemosensation. Molecular interventions\| PubMed ID: 18403652	2008
Incretin-based therapies in type 2 diabetes mellitus. The Journal of clinical endocrinology and metabolism\| PubMed ID: 18628530	2008
The role of incretins in glucose homeostasis and diabetes treatment. Pharmacological reviews\| PubMed ID: 19074620	2008
Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes. Diabetes..\| PubMed ID: 19276444	2009
Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure? Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 20008676	2010
Role and development of GLP-1 receptor agonists in the management of diabetes. Diabetes, metabolic syndrome and obesity : targets and therapy\| PubMed ID: 20148188	2009
Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes..\| PubMed ID: 20150284	2010
Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20498254	2010
Glucagon signaling modulates sweet taste responsiveness. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20547661	2010
Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PloS one\| PubMed ID: 20856820	2010
Insulin and glucagon regulate pancreatic α-cell proliferation. PloS one\| PubMed ID: 21283589	2011
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes..\| PubMed ID: 21346174	2011
Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism. The Journal of clinical endocrinology and metabolism\| PubMed ID: 21389141	2011
Hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: unraveling the role of gut hormonal and pancreatic endocrine dysfunction. The Journal of surgical research\| PubMed ID: 21414635	2011
To be or not to be--obese. Endocrinology\| PubMed ID: 21937750	2011
SRT1720 improves survival and healthspan of obese mice. Scientific reports\| PubMed ID: 22355589	2011
RNA-binding protein HuD controls insulin translation. Molecular cell\| PubMed ID: 22387028	2012
Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults. Journal of the American Geriatrics Society\| PubMed ID: 22417789	2012
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation. Science signaling\| PubMed ID: 22434934	2012
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS genetics\| PubMed ID: 22479202	2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature genetics\| PubMed ID: 22581228	2012
Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PloS one\| PubMed ID: 22808093	2012
Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy. The Journal of biological chemistry\| PubMed ID: 22822065	2012
Perinatal exercise improves glucose homeostasis in adult offspring. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22932781	2012
Pancreas++: automated quantification of pancreatic islet cells in microscopy images. Frontiers in physiology\| PubMed ID: 23293605	2012
Hormonal response to a mixed-meal challenge after reversal of gastric bypass for hypoglycemia. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23666968	2013
Resveratrol Prevents Î²-cell Dedifferentiation in Non-Human Primates Given a High Fat/ High Sugar Diet. Diabetes\| PubMed ID: 23884882	2013
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell metabolism\| PubMed ID: 24093677	2013
Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. Journal of natural products\| PubMed ID: 24175626	2013
Incretin therapy and pancreatic pathologies: background pathology versus drug-induced pathology in rats. Diabetes..\| PubMed ID: 24651798	2014
GIP contributes to islet trihormonal abnormalities in type 2 diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24712564	2014
Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients. Frontiers in physiology\| PubMed ID: 25002850	2014
Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia\| PubMed ID: 25016595	2014
Pancreatic polypeptide inhibits somatostatin secretion. FEBS letters\| PubMed ID: 25019573	2014
Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity. The Journal of endocrinology\| PubMed ID: 25297556	2014
Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds. Cancer medicine\| PubMed ID: 25354792	2015
Mechanisms of type 2 diabetes resolution after Roux-en-Y gastric bypass. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery\| PubMed ID: 25443077	2014
Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 26921861	2016
Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells. PloS one\| PubMed ID: 26967640	2016
Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism. Scientific reports\| PubMed ID: 27641999	2016
Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudina... Diabetes\| PubMed ID: 27737951	2017
Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study. PloS one\| PubMed ID: 27880832	2016
Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 27914737	2017
Incretin secretion in humans is under the influence of cannabinoid receptors. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 28655715	2017
Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 29055815	2018
Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference. Scientific reports\| PubMed ID: 29234141	2017
Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells. Journal of cellular and molecular medicine\| PubMed ID: 29431265	2018
Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets. Diabetologia\| PubMed ID: 29497784	2018
Measurement of fat fraction in the human thymus by localized NMR and three-point Dixon MRI techniques. Magnetic resonance imaging\| PubMed ID: 29605590	2018
Endocannabinoids in the Islets of Langerhans: the ugly, the bad, and the good facts. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 29631361	2018
Regular low-calorie sweetener consumption is associated with increased secretion of glucose-dependent insulinotropic polypeptide. Diabetes, obesity & metabolism\| PubMed ID: 29687583	2018
Insulin Is Transcribed and Translated in Mammalian Taste Bud Cells. Endocrinology\| PubMed ID: 30060183	2018
Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk. Circulation research\| PubMed ID: 30355075	2018
Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle St... The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 30380014	2019
Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30726112	2019
Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity. Nutrition & metabolism\| PubMed ID: 31372175	2019
Incretins in obesity and diabetes. Annals of the New York Academy of Sciences\| PubMed ID: 31392745	2020
Effect of Rifaximin Treatment on Endotoxemia and Insulin Sensitivity in Humans. Journal of the Endocrine Society\| PubMed ID: 31428718	2019
A Pilot Study of Exenatide Actions in Alzheimer's Disease. Current Alzheimer research\| PubMed ID: 31518224	2019
Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies. Ageing research reviews\| PubMed ID: 31870908	2020
An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice. Archives of toxicology\| PubMed ID: 31912162	2020
A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging. Journal of internal medicine\| PubMed ID: 32107805	2020
Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism\| PubMed ID: 32413333	2020
Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling. Cell death & disease\| PubMed ID: 33298885	2020
Age-associated expression of p21and p53 during human wound healing. Aging cell\| PubMed ID: 33835683	2021
Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The American journal of pathology\| PubMed ID: 34102107	2021
An Autonomous Cannabinoid System in Islets of Langerhans. Frontiers in endocrinology\| PubMed ID: 34290671	2021
Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging. Frontiers in aging neuroscience\| PubMed ID: 34603011	2021
Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus. Diabetes..\| PubMed ID: 34649926	2021
Longitudinal trajectories and determinants of human fungiform papillae density. Aging\| PubMed ID: 34857670	2021
Comparison of Hormonal Response to a Mixed-Meal Challenge in Hypoglycemia After Sleeve Gastrectomy vs Gastric Bypass. The Journal of clinical endocrinology and metabolism\| PubMed ID: 35914520	2022
Differences in the choroid plexus volume and microstructure are associated with body adiposity. Frontiers in endocrinology\| PubMed ID: 36313760	2022
Physiology of the tongue with emphasis on taste transduction. Physiological reviews\| PubMed ID: 36422992	2023
Longitudinal phenotypic aging metrics in the Baltimore Longitudinal Study of Aging. Nature aging\| PubMed ID: 36910594	2022
Endocrinology of Taste with Aging. Endocrinology and metabolism clinics of North America\| PubMed ID: 36948781	2023
Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 37283066	2023
Long-Term Dysfunction of Taste Papillae in SARS-CoV-2. NEJM evidence\| PubMed ID: 38145006	2023
Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion. iScience\| PubMed ID: 38162029	2023
An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington's disease. Scientific reports\| PubMed ID: 38212353	2024
Pancreatic β cell derived extracellular vesicles containing surface preproinsulin are involved in glucose stimulated insulin secretion. Life sciences\| PubMed ID: 38286207	2024
Association of Plasma Markers of Alzheimer's Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging. Aging and disease\| PubMed ID: 38300640	2024
Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression. Cancer research\| PubMed ID: 38330147	2024
Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice. Molecular metabolism\| PubMed ID: 38423253	2024
Corrigendum to "Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice" [Mol Metab 82 (2024 April) 101906]. Molecular metabolism\| PubMed ID: 38499184	2024
Physiological Integration of Taste and Metabolism. The New England journal of medicine\| PubMed ID: 38718360	2024
Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans. Diabetologia\| PubMed ID: 38864887	2024
An Insulin Upstream Open Reading Frame (INSU) Is Present in Skeletal Muscle Satellite Cells: Changes with Age. Cells\| PubMed ID: 39594651	2024
Skeletal Muscle mRNA Splicing Variants Association With Four Different Fitness and Energetic Measures in the GESTALT Study. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 39621510	2025
Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 39849049	2025
Correction: Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans. Diabetologia\| PubMed ID: 39954060	2025
Age-Related Differences in the Choroid Plexus Structural Integrity Are Associated with Changes in Cognition. medRxiv : the preprint server for health sciences\| PubMed ID: 40061356	2025
Qualitative and quantitative lipidomic profiling of cardiolipin, oxidized cardiolipin, and monolysocardiolipin from human skeletal muscle by UPLC-Orbitrap-MS. Analytica chimica acta\| PubMed ID: 40155162	2025