hydroxysafflor-yellow-attenuates-lps-induced-toxicity-dopaminergic

Hydroxysafflor Yellow A Attenuates LPS-Induced Toxicity in Dopaminergic Neurons of Zebrafish by Regulating the TLR4/NF-&#312;B Signaling Pathway

Lipopolysaccharide (LPS)-induced inflammation plays a crucial role in triggering and perpetuating the neurodegenerative diseases, including Parkinson's ...

lansoprazole-improves-long-term-neurological-function-via-alleviating

Lansoprazole Improves Long-Term Neurological Function <em>via</em> Alleviating Intestinal Injury in a Mouse Model of Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) can compromise the gastrointestinal tract and trigger intestinal injury, contributing to poor clinical outcomes. This study ...

Yantai University

Depression is a common non-motor symptom of Parkinson's disease. Previous studies demonstrated that hydroxysafflor yellow A had properties of improving motor symptoms of Parkinson's disease. The effect of hydroxysafflor yellow A on depression in Parkinson's disease mice is investigated in this study. To induce Parkinson's disease model, male Swiss mice were exposed to rotenone (30 mg/kg) for 6 weeks. The chronic unpredictable mild stress was employed to induce depression from week 3 to week 6. Sucrose preference, tail suspension, and forced swimming tests were conducted. Golgi and Nissl staining of hippocampus were carried out. The levels of dopamine, 5-hydroxytryptamine and the expression of postsynaptic density protein 95, brain-derived neurotrophic factor in hippocampus were assayed. It showed that HSYA improved the depression-like behaviors of Parkinson's disease mice. Hydroxysafflor yellow A attenuated the injury of nerve and elevated contents of dopamine, 5-hydroxytryptamine in hippocampus. Treatment with hydroxysafflor yellow A also augmented the expression of postsynaptic density protein 95 and brain-derived neurotrophic factor. These findings suggest that hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice through regulating the contents of postsynaptic density protein 95 and brain-derived neurotrophic factor, therefore protecting neurons and neuronal dendrites of the hippocampus.

Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice.

A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional group compatibility. Gram-scale experiments demonstrated the potential applications of this reaction. Moreover, the preliminary fluorescence results uncovered that dipyrazole-fused pyridazines and pyrazines may have some potential applications in materials chemistry.

5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds.

To investigate the relationship between secondary brain injury and intestinal injury in intracerebral hemorrhage (ICH) and whether escin can protect the function of the intestine and inhibit lipopolysaccharide (LPS) entry into the blood, thereby attenuating brain injury after ICH.

Escin displays neuroprotective effects in mice with intracerebral hemorrhage through ameliorating intestinal injury.

Neural stem cells (NSCs) showed a promising approach to treat Alzheimer's disease (AD). This study aims to investigate whether mouse NSCs transplantation can improve the function of learning and memory of AD mouse model and the underlying mechanism. NSCs was stereotaxically injected into the hippocampi of ibotenic acid (IBO)-induced AD mice. Behavioral tests were conducted to evaluate neurological function. Golgi and immunofluorescence staining were used to assess the injury of the nerves. Additionally, enhanced green fluorescent protein (EGFP) labeling was employed to evaluate the differentiation of NSCs. Compared with model group, NSCs transplantation shortened the escape latency and increased the crossing platform quadrant time, number of crossing the platform (p < 0.01). The preference index and active avoidance rate was increased after NSCs transplantation when compared with the model group (p < 0.05 or p < 0.01). NSCs augmented not only the number of neurons in the hippocampal CA1 region, but also the dendritic spine density, dendritic complexity and ACh content in the hippocampus (p < 0.05 or p < 0.01). Furthermore, NSCs also elevated the levels of BDNF in the hippocampus of AD mice (p < 0.01). It also showed that a portion of transplanted NSCs differentiated into neurons at four weeks post-transplantation. These results demonstrated that NSCs improved learning and memory function in the AD model by ameliorating neuron injury and differentiating into neurons.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Article	Year
Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice. Pakistan journal of pharmaceutical sciences\| PubMed ID: 38822547	2024
5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds. Molecules (Basel, Switzerland)\| PubMed ID: 39860249	2025
Escin displays neuroprotective effects in mice with intracerebral hemorrhage through ameliorating intestinal injury. American journal of translational research\| PubMed ID: 41268242	2025
Neural stem cells improve the function of learning and memory in the ibotenic acid-induced Alzheimer's disease mice. Behavioural brain research\| PubMed ID: 41308879	2026

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