hydroxysafflor-yellow-attenuates-lps-induced-toxicity-dopaminergic

Hydroxysafflor Yellow A Attenuates LPS-Induced Toxicity in Dopaminergic Neurons of Zebrafish by Regulating the TLR4/NF-&#312;B Signaling Pathway

Lipopolysaccharide (LPS)-induced inflammation plays a crucial role in triggering and perpetuating the neurodegenerative diseases, including Parkinson's ...

lansoprazole-improves-long-term-neurological-function-via-alleviating

Lansoprazole Improves Long-Term Neurological Function <em>via</em> Alleviating Intestinal Injury in a Mouse Model of Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) can compromise the gastrointestinal tract and trigger intestinal injury, contributing to poor clinical outcomes. This study ...

Yinfeng Biological Group Co., Ltd.

Yantai University

Shandong Xiehe University

Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown.

Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect.

Association of  gene polymorphisms with asthenozoospermia in Northeast Chinese patients.

To evaluate the efficacy of preimplantation genetic testing (PGT) for α- and β-double thalassemia combined with aneuploidy screening using next-generation sequencing (NGS).

Eleven healthy live births: a result of simultaneous preimplantation genetic testing of α- and β-double thalassemia and aneuploidy screening.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, with a complex pathogenesis and an irreversible course. Therefore, the early diagnosis of AD is particularly important for the intervention, prevention, and treatment of the disease. Based on the different pathophysiological mechanisms of AD, the research progress of biofluid biomarkers are classified and reviewed. In the end, the challenges and perspectives of future research are proposed.

Biofluid biomarkers for Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disease that is still incurable. Therapy with stem cell or extracellular vesicles is a promising strategy for AD treatment. Therefore, we evaluated whether stem cell-derived extracellular vesicles could improve cognitive function and pathological features in AD model mice.

Efficacy of Stem Cell-derived Extracellular Vesicles in the Treatment of Alzheimer's Disease Model Mice: A Systematic Review and Meta-analysis.

Neural stem cells (NSCs) showed a promising approach to treat Alzheimer's disease (AD). This study aims to investigate whether mouse NSCs transplantation can improve the function of learning and memory of AD mouse model and the underlying mechanism. NSCs was stereotaxically injected into the hippocampi of ibotenic acid (IBO)-induced AD mice. Behavioral tests were conducted to evaluate neurological function. Golgi and immunofluorescence staining were used to assess the injury of the nerves. Additionally, enhanced green fluorescent protein (EGFP) labeling was employed to evaluate the differentiation of NSCs. Compared with model group, NSCs transplantation shortened the escape latency and increased the crossing platform quadrant time, number of crossing the platform (p < 0.01). The preference index and active avoidance rate was increased after NSCs transplantation when compared with the model group (p < 0.05 or p < 0.01). NSCs augmented not only the number of neurons in the hippocampal CA1 region, but also the dendritic spine density, dendritic complexity and ACh content in the hippocampus (p < 0.05 or p < 0.01). Furthermore, NSCs also elevated the levels of BDNF in the hippocampus of AD mice (p < 0.01). It also showed that a portion of transplanted NSCs differentiated into neurons at four weeks post-transplantation. These results demonstrated that NSCs improved learning and memory function in the AD model by ameliorating neuron injury and differentiating into neurons.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Article	Year
Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect. Reproductive biology and endocrinology : RB&E\| PubMed ID: 30390692	2018
Association of gene polymorphisms with asthenozoospermia in Northeast Chinese patients. Bioscience reports\| PubMed ID: 31160482	2019
Eleven healthy live births: a result of simultaneous preimplantation genetic testing of α- and β-double thalassemia and aneuploidy screening. Journal of assisted reproduction and genetics\| PubMed ID: 32152910	2020
Biofluid biomarkers for Alzheimer's disease. Frontiers in aging neuroscience\| PubMed ID: 38659704	2024
Efficacy of Stem Cell-derived Extracellular Vesicles in the Treatment of Alzheimer's Disease Model Mice: A Systematic Review and Meta-analysis. Current stem cell research & therapy\| PubMed ID: 40257023	2025
Neural stem cells improve the function of learning and memory in the ibotenic acid-induced Alzheimer's disease mice. Behavioural brain research\| PubMed ID: 41308879	2026

Guirong Zhang

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