Suowen Xu

Department of Endocrinology, University of Science and Technology of China

Affiliated withUniversity of Science and Technology of China Anhui Provincial Key Laboratory of Metabolic Health and Panvascular Diseases

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Other Publications

Article	Year
Hydrogen Sulfide (HS)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases. Frontiers in pharmacology\| PubMed ID: 30298008	2018
Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential. Pharmacological research\| PubMed ID: 30408571	2019
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics\| PubMed ID: 31037148	2019
ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review. Progress in lipid research\| PubMed ID: 31499095	2020
Therapeutic potential of blood flow mimetic compounds in preventing endothelial dysfunction and atherosclerosis. Pharmacological research\| PubMed ID: 32126273	2020
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity. Aging\| PubMed ID: 32139662	2020
Familial Hypercholesterolemia and Atherosclerosis: Animal Models and Therapeutic Advances. Trends in endocrinology and metabolism: TEM\| PubMed ID: 32305096	2020
Epigenetics in atherosclerosis: key features and therapeutic implications. Expert opinion on therapeutic targets\| PubMed ID: 32354276	2020
Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function. Frontiers in pharmacology\| PubMed ID: 32457625	2020
COVID-19 and Kawasaki disease in children. Pharmacological research\| PubMed ID: 32464327	2020
Natural products, PGC-1 , and Duchenne muscular dystrophy. Acta pharmaceutica Sinica. B\| PubMed ID: 32528825	2020
Toll-like Receptor 4 Stimulates Gene Expression via Smad2 Linker Region Phosphorylation in Vascular Smooth Muscle Cells. ACS pharmacology & translational science\| PubMed ID: 32566917	2020
Cyclodextrins: Potential therapeutics against atherosclerosis. Pharmacology & therapeutics\| PubMed ID: 32599008	2020
Targeting inflammation and cytokine storm in COVID-19. Pharmacological research\| PubMed ID: 32603772	2020
CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications. Current atherosclerosis reports\| PubMed ID: 32772254	2020
Traditional Chinese medicine in cardiovascular drug discovery. Pharmacological research\| PubMed ID: 32853746	2020
Statins: Epidrugs with effects on endothelial health? European journal of clinical investigation\| PubMed ID: 32854143	2020
Naringenin and naringin in cardiovascular disease prevention: A preclinical review. European journal of pharmacology\| PubMed ID: 32910944	2020
Autophagy and cardiac diseases: Therapeutic potential of natural products. Medicinal research reviews\| PubMed ID: 32969064	2021
Editorial: Biomechanics in Translation: From Vascular Biology to Cardiovascular Drug Discovery. Frontiers in bioengineering and biotechnology\| PubMed ID: 32974294	2020
Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential. European journal of pharmacology\| PubMed ID: 33010303	2021
Medicinal plants and bioactive natural compounds as inhibitors of HMG-CoA reductase: A literature review. BioFactors (Oxford, England)\| PubMed ID: 33053603	2020
The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms. Oxidative medicine and cellular longevity\| PubMed ID: 33062143	2020
The role of potassium in atherosclerosis. European journal of clinical investigation\| PubMed ID: 33216974	2021
Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review. Frontiers in cell and developmental biology\| PubMed ID: 33282862	2020
Natural products: The role and mechanism in low-density lipoprotein oxidation and atherosclerosis. Phytotherapy research : PTR\| PubMed ID: 33368763	2021
Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics. Theranostics\| PubMed ID: 33754074	2021
Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovascular research\| PubMed ID: 33757117	2022
Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome. Phytotherapy research : PTR\| PubMed ID: 33856730	2021
Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. Molecules (Basel, Switzerland)\| PubMed ID: 33923651	2021
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3. Cell death and differentiation\| PubMed ID: 33947971	2021
A bibliometric study of COVID-19 research in Web of Science. Pharmacological research\| PubMed ID: 33979689	2021
Targeting angiopoietin-like 3 in atherosclerosis: From bench to bedside. Diabetes, obesity & metabolism\| PubMed ID: 34047441	2021
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies. Pharmacological reviews\| PubMed ID: 34088867	2021
Resveratrol and endothelial function: A literature review. Pharmacological research\| PubMed ID: 34119624	2021
GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential. International journal of biological sciences\| PubMed ID: 34131405	2021
Metformin, Macrophage Dysfunction and Atherosclerosis. Frontiers in immunology\| PubMed ID: 34163481	2021
The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal transduction and targeted therapy\| PubMed ID: 34253708	2021
Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules (Basel, Switzerland)\| PubMed ID: 34279384	2021
The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis of Randomiz... Mediators of inflammation\| PubMed ID: 34526854	2021
Harnessing polyphenol power by targeting eNOS for vascular diseases. Critical reviews in food science and nutrition\| PubMed ID: 34553653	2023
The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes. Endocrine connections\| PubMed ID: 34636748	2021
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function. Theranostics\| PubMed ID: 34646376	2021
PCSK9 Inhibition-Based Therapeutic Approaches: An Immunotherapy Perspective. Current medicinal chemistry\| PubMed ID: 34711156	2022
The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low-Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta-Analysis. Oxidative medicine and cellular longevity\| PubMed ID: 34912496	2021
Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE mice. Pharmacological research\| PubMed ID: 34954030	2022
The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy. International journal of biological sciences\| PubMed ID: 35002525	2022
Natural Products and Cardiovascular Diseases. Current molecular pharmacology\| PubMed ID: 35018881	2021
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review. Acta pharmacologica Sinica\| PubMed ID: 35046517	2022
Natural AMPK Activators in Cardiovascular Disease Prevention. Frontiers in pharmacology\| PubMed ID: 35046800	2021
Editorial: Epigenetic Regulation in Cardiovascular Diseases. Frontiers in cardiovascular medicine\| PubMed ID: 35087888	2021
Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2. International journal of biological sciences\| PubMed ID: 35342347	2022
Marijuana and endothelial dysfunction: new mechanism and therapy. Trends in molecular medicine\| PubMed ID: 35701315	2022
Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis. Pharmacological research\| PubMed ID: 35716915	2022
Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis. Frontiers in cardiovascular medicine\| PubMed ID: 35722128	2022
Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action. Antioxidants (Basel, Switzerland)\| PubMed ID: 35739982	2022
Hyperglycemia-mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance. Journal of diabetes investigation\| PubMed ID: 35839128	2022
Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway. Frontiers in immunology\| PubMed ID: 35865527	2022
A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice. Biochemical and biophysical research communications\| PubMed ID: 35868060	2022
Mouse models of atherosclerosis in translational research. Trends in pharmacological sciences\| PubMed ID: 35902281	2022
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics. Signal transduction and targeted therapy\| PubMed ID: 35918332	2022
A review on therapeutical potential of paeonol in atherosclerosis. Frontiers in pharmacology\| PubMed ID: 35991897	2022
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 36058153	2022
Comparative Proteomic Analysis of Liver Tissues and Serum in / Mice. International journal of molecular sciences\| PubMed ID: 36077090	2022
, a coronary artery disease risk gene, mediates endothelial dysfunction. Frontiers in immunology\| PubMed ID: 36091033	2022
Kaempferol and atherosclerosis: From mechanism to medicine. Critical reviews in food science and nutrition\| PubMed ID: 36099317	2024
Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling. Redox biology\| PubMed ID: 36162256	2022
Vascular homeostasis in atherosclerosis: A holistic overview. Frontiers in immunology\| PubMed ID: 36172381	2022
Advancing cardiovascular translational research. Trends in pharmacological sciences\| PubMed ID: 36184339	2022
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies. Acta pharmacologica Sinica\| PubMed ID: 36253560	2023
Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies. International journal of biological sciences\| PubMed ID: 36263163	2022
Differential Effects of Beta-Hydroxybutyrate Enantiomers on Induced Pluripotent Stem Derived Cardiac Myocyte Electrophysiology. Biomolecules\| PubMed ID: 36291708	2022
Serum Metabolomic Profiling in Aging Mice Using Liquid Chromatography-Mass Spectrometry. Biomolecules\| PubMed ID: 36358944	2022
Non-Mouse Models of Atherosclerosis: Approaches to Exploring the Translational Potential of New Therapies. International journal of molecular sciences\| PubMed ID: 36361754	2022
Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. Nutrients\| PubMed ID: 36364780	2022
Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells. International journal of molecular sciences\| PubMed ID: 36430902	2022
Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine. International journal of biological sciences\| PubMed ID: 36594101	2023
Growth differentiation factor 15 is dispensable for acetaminophen-induced liver injury in mice. Basic & clinical pharmacology & toxicology\| PubMed ID: 36602134	2023
Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective. Frontiers in immunology\| PubMed ID: 36618414	2022
The temporal trend of disease burden attributable to metabolic risk factors in China, 1990-2019: An analysis of the Global Burden of Disease study. Frontiers in nutrition\| PubMed ID: 36687675	2022
ASGR1: an emerging therapeutic target in hypercholesterolemia. Signal transduction and targeted therapy\| PubMed ID: 36690631	2023
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. European heart journal\| PubMed ID: 36721994	2023
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling. Journal of hypertension\| PubMed ID: 36883465	2023
Editorial: Epigenetic regulation in cardiovascular diseases, volume II. Frontiers in cardiovascular medicine\| PubMed ID: 36950284	2023
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs. Acta pharmacologica Sinica\| PubMed ID: 36997664	2023
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases. Inflammopharmacology\| PubMed ID: 36997729	2023
Regular consumption of pickled vegetables and fermented bean curd reduces the risk of diabetes: a prospective cohort study. Frontiers in public health\| PubMed ID: 37181698	2023
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies. Signal transduction and targeted therapy\| PubMed ID: 37244925	2023
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics. Acta pharmacologica Sinica\| PubMed ID: 37550526	2023
Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery. Acta pharmacologica Sinica\| PubMed ID: 37644131	2024
Cell-inspired design of cascade catalysis system by 3D spatially separated active sites. Nature communications\| PubMed ID: 37660124	2023
Aprocitentan, a dual endothelin-1 (ET-1) antagonist for treating resistant hypertension: Mechanism of action and therapeutic potential. Drug discovery today\| PubMed ID: 37742911	2023
AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation. Antioxidants (Basel, Switzerland)\| PubMed ID: 37759984	2023
M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics. Arthritis research & therapy\| PubMed ID: 37784134	2023
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells. Inflammation\| PubMed ID: 37819455	2024
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection. Pharmacological research\| PubMed ID: 38056513	2024
Editorial: Novel strategies for the prevention and treatment of foam cell formation and atherosclerosis. Frontiers in cardiovascular medicine\| PubMed ID: 38075953	2023
TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase. The Journal of clinical investigation\| PubMed ID: 38206764	2024
[Not Available]. Acta pharmaceutica Sinica. B\| PubMed ID: 38239238	2024
The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy. International journal of biological sciences\| PubMed ID: 38250153	2024
NAFLD and NASH: etiology, targets and emerging therapies. Drug discovery today\| PubMed ID: 38301798	2024
Endothelial lipid droplets drive atherosclerosis and arterial hypertension. Trends in endocrinology and metabolism: TEM\| PubMed ID: 38431437	2024
Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. Journal of advanced research\| PubMed ID: 38432393	2025
Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019. JAMA neurology\| PubMed ID: 38436973	2024
A novel mouse model of familial combined hyperlipidemia and atherosclerosis. Acta pharmacologica Sinica\| PubMed ID: 38459255	2024
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition. Pharmacological research\| PubMed ID: 38522762	2024
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases. British journal of pharmacology\| PubMed ID: 38528718	2024
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway. Acta pharmacologica Sinica\| PubMed ID: 38589689	2024
Editorial: Community series in epigenetic regulation in cardiovascular diseases, volume III. Frontiers in cardiovascular medicine\| PubMed ID: 38689860	2024
Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy. The Journal of experimental medicine\| PubMed ID: 38695876	2024
The natural polyphenol fisetin in atherosclerosis prevention: a mechanistic review. The Journal of pharmacy and pharmacology\| PubMed ID: 38733634	2025
Bioactive Flavonoids in Protecting Against Endothelial Dysfunction and Atherosclerosis. Handbook of experimental pharmacology\| PubMed ID: 38755351	2025
The emerging role of ACOD1/itaconate pathway in atherosclerosis. Trends in molecular medicine\| PubMed ID: 38845325	2024
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice. Acta pharmacologica Sinica\| PubMed ID: 38886550	2024
Profiling of Antidiabetic Bioactive Flavonoid Compounds from an Edible Plant Kudzu (). Journal of agricultural and food chemistry\| PubMed ID: 38976778	2024
Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases. Trends in endocrinology and metabolism: TEM\| PubMed ID: 39122600	2025
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake. Circulation research\| PubMed ID: 39234692	2024
Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential. Journal of cardiovascular pharmacology\| PubMed ID: 39240726	2024
Mn-Ce Symbiosis: Nanozymes with Multiple Active Sites Facilitate Scavenging of Reactive Oxygen Species (ROS) Based on Electron Transfer and Confinement Anchoring. Angewandte Chemie (International ed. in English)\| PubMed ID: 39327805	2025
Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 39343155	2024
Vascular dysfunction in Hutchinson-Gilford progeria syndrome. Trends in molecular medicine\| PubMed ID: 39741011	2025
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis. Nature cardiovascular research\| PubMed ID: 39794479	2025
Aclysiran, an RNAi therapeutic agent targeting ACLY, treats hypercholesterolemia and atherosclerosis in mice. Acta pharmaceutica Sinica. B\| PubMed ID: 39807322	2024
Prioritization of Lipid Metabolism Targets for the Diagnosis and Treatment of Cardiovascular Diseases. Research (Washington, D.C.)\| PubMed ID: 39975574	2025
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways. Cardiovascular research\| PubMed ID: 39982773	2025
The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21. Science advances\| PubMed ID: 40138418	2025
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake. The Journal of clinical investigation\| PubMed ID: 40166941	2025
Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice-Brief Report. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 40177774	2025
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY. Theranostics\| PubMed ID: 40225566	2025
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway. Acta pharmacologica Sinica\| PubMed ID: 40263569	2025
Revisiting the role of GDF15 in atherosclerosis in mouse and human. Acta pharmacologica Sinica\| PubMed ID: 40307459	2025
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021. JAMA neurology\| PubMed ID: 40406922	2025
HIV infection, antiretroviral therapy and vascular dysfunction: Effects, mechanisms and treatments. Pharmacological research\| PubMed ID: 40460975	2025
Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation. Acta pharmacologica Sinica\| PubMed ID: 40670675	2025
Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation. Research (Washington, D.C.)\| PubMed ID: 40765997	2025