Gordon C. Weir

Joslin Diabetes Center, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines. The Journal of clinical investigation\| PubMed ID: 4373494	1974
In vitro cultivation of human islets from expanded ductal tissue. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10884429	2000
Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes\| PubMed ID: 11272180	2001
Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes\| PubMed ID: 12502495	2003
Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Development, growth & differentiation\| PubMed ID: 12630945	2003
Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation\| PubMed ID: 12694544	2003
PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes\| PubMed ID: 12829640	2003
Importance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation\| PubMed ID: 12973104	2003
Can we make surrogate beta-cells better than the original? Seminars in cell & developmental biology\| PubMed ID: 15125898	2004
Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transplant immunology\| PubMed ID: 15381202	2004
Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes\| PubMed ID: 15561905	2004
Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation\| PubMed ID: 15714169	2005
Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochemical and biophysical research communications\| PubMed ID: 15752744	2005
Islet transplantation: progress and challenge. Archives of medical research\| PubMed ID: 15925017	2005
New sources of pancreatic beta-cells. Nature biotechnology\| PubMed ID: 16003374	2005
Establishment of a diabetic mouse model with progressive diabetic nephropathy. The American journal of pathology\| PubMed ID: 16049320	2005
Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes\| PubMed ID: 16644676	2006
NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes/metabolism research and reviews\| PubMed ID: 16921545	2007
A dominant role for glucose in beta cell compensation of insulin resistance. The Journal of clinical investigation\| PubMed ID: 17200709	2007
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes\| PubMed ID: 17360984	2007
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes\| PubMed ID: 17363743	2007
A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnology and bioengineering\| PubMed ID: 17497731	2007
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. The Journal of clinical endocrinology and metabolism\| PubMed ID: 18073315	2008
Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation\| PubMed ID: 18447886	2008
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimul... The Journal of clinical endocrinology and metabolism\| PubMed ID: 18664535	2008
Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes/metabolism research and reviews\| PubMed ID: 18727153	2008
Malic enzyme is present in mouse islets and modulates insulin secretion. Diabetologia\| PubMed ID: 18802677	2008
An appreciation of Robert Turner. Diabetes\| PubMed ID: 18971441	2008
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney international\| PubMed ID: 19008912	2008
Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 diabetes. Current diabetes reports\| PubMed ID: 19323953	2009
Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes, obesity & metabolism\| PubMed ID: 19817791	2009
Current status of islet cell replacement and regeneration therapy. The Journal of clinical endocrinology and metabolism\| PubMed ID: 20061422	2010
Ductal origin hypothesis of pancreatic regeneration under attack. Cell metabolism\| PubMed ID: 20085728	2010
Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology\| PubMed ID: 20570953	2010
Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PloS one\| PubMed ID: 20585452	2010
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PloS one\| PubMed ID: 20644627	2010
Enumeration of islets by nuclei counting and light microscopic analysis. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 20697375	2010
Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 20697378	2010
A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials\| PubMed ID: 20828808	2010
Beta-cell growth and regeneration: replication is only part of the story. Diabetes\| PubMed ID: 20876724	2010
Sleeping islets and the relationship between β-cell mass and function. Diabetes\| PubMed ID: 21788579	2011
Finally! A human pancreatic β cell line. The Journal of clinical investigation\| PubMed ID: 21865653	2011
Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocrine reviews\| PubMed ID: 21951347	2011
Stem cell approaches for diabetes: towards beta cell replacement. Genome medicine\| PubMed ID: 21951399	2011
Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion. Endocrinology\| PubMed ID: 22919061	2012
Cellular transplantation into lymph nodes may not be such a crazy idea. Cell stem cell\| PubMed ID: 23122285	2012
Concise review: pancreas regeneration: recent advances and perspectives. Stem cells translational medicine\| PubMed ID: 23197762	2012
Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes\| PubMed ID: 23305647	2013
Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell transplantation\| PubMed ID: 23321263	2014
Islet β cell mass in diabetes and how it relates to function, birth, and death. Annals of the New York Academy of Sciences\| PubMed ID: 23363033	2013
Islet encapsulation: advances and obstacles. Diabetologia\| PubMed ID: 23636639	2013
Enhanced function of immuno-isolated islets in diabetes therapy byÂ co-encapsulation with an anti-inflammatory drug. Biomaterials\| PubMed ID: 23660251	2013
PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes\| PubMed ID: 23775765	2013
Islet neogenesis: a possible pathway for beta-cell replenishment. The review of diabetic studies : RDS\| PubMed ID: 23804276	2012
Making β cells from adult cells within the pancreas. Current diabetes reports\| PubMed ID: 23925431	2013
Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration. Endocrinology\| PubMed ID: 24029238	2013
Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. PloS one\| PubMed ID: 24204831	2013
β-cell dedifferentiation in diabetes is important, but what is it? Islets\| PubMed ID: 24356710	2013
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24712577	2014
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes care\| PubMed ID: 24812433	2014
Repurposing cAMP-modulating medications to promote β-cell replication. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 25083741	2014
Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells. Diabetes\| PubMed ID: 25488899	2015
Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 25604813	2015
Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology\| PubMed ID: 25836667	2015
Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation. PloS one\| PubMed ID: 26258815	2015
Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation\| PubMed ID: 26840096	2016
Dynamic development of the pancreas from birth to adulthood. Upsala journal of medical sciences\| PubMed ID: 26998806	2016
Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. Transplantation\| PubMed ID: 27082827	2016
Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI insight\| PubMed ID: 27152363	2016
Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 27455412	2016
GABA Signaling Stimulates β Cell Regeneration in Diabetic Mice. Cell\| PubMed ID: 28086099	2017
Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Frontiers in genetics\| PubMed ID: 28174593	2017
Evidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors. Islets\| PubMed ID: 28252345	2017
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell metabolism\| PubMed ID: 28380379	2017
Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics. Pediatric diabetes\| PubMed ID: 29473705	2018
Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression. PloS one\| PubMed ID: 30303984	2018
Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations. Nature materials\| PubMed ID: 31235902	2019
Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes. Diabetes\| PubMed ID: 31519699	2020
Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes. The lancet. Diabetes & endocrinology\| PubMed ID: 32006519	2020
Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability. Molecular metabolism\| PubMed ID: 32244186	2020
β-cell secretory dysfunction: a key cause of type 2 diabetes - Authors' reply. The lancet. Diabetes & endocrinology\| PubMed ID: 32333872	2020
A novel cellular engineering approach to diabetes mellitus. Nature reviews. Endocrinology\| PubMed ID: 32665618	2020
Reduced glucose-induced first-phase insulin release is a danger signal that predicts diabetes. The Journal of clinical investigation\| PubMed ID: 34128470	2021
The β-cell glucose toxicity hypothesis: Attractive but difficult to prove. Metabolism: clinical and experimental\| PubMed ID: 34480921	2021
Islet Inflammation Can Be Linked to the Disruption of Proinsulin Processing in Type 1 Diabetes but not in Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 36317646	2023
Induction of remission in diabetes by lowering blood glucose. Frontiers in endocrinology\| PubMed ID: 37409234	2023
Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells. Diabetes\| PubMed ID: 37983524	2023
Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel. Cell transplantation\| PubMed ID: 39361612	2024