Cristina Aguayo-Mazzucato

Joslin Diabetes Center, Harvard Medical School

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Stem cell therapy for type 1 diabetes mellitus. Nature reviews. Endocrinology\| PubMed ID: 20173775	2010
Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion. Endocrinology\| PubMed ID: 22919061	2012
Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes\| PubMed ID: 23305647	2013
PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes\| PubMed ID: 23775765	2013
β-cell dedifferentiation in diabetes is important, but what is it? Islets\| PubMed ID: 24356710	2013
MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. The Journal of clinical endocrinology and metabolism\| PubMed ID: 26207953	2015
Dynamic development of the pancreas from birth to adulthood. Upsala journal of medical sciences\| PubMed ID: 26998806	2016
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell metabolism\| PubMed ID: 28380379	2017
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes. Cell metabolism\| PubMed ID: 28889951	2018
T Induces Both Markers of Maturation and Aging in Pancreatic β-Cells. Diabetes\| PubMed ID: 29625991	2018
Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States. Diabetes/metabolism research and reviews\| PubMed ID: 30445663	2019
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell metabolism\| PubMed ID: 31155496	2019
β-cell senescence in type 2 diabetes. Aging\| PubMed ID: 31767811	2019
Functional changes in beta cells during ageing and senescence. Diabetologia\| PubMed ID: 32894312	2020
Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors. Diabetes\| PubMed ID: 33674410	2021
Effects of exercise on cellular and tissue aging. Aging\| PubMed ID: 34001677	2021
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers. GeroScience\| PubMed ID: 34773197	2022
Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control. Diabetes\| PubMed ID: 35100352	2022
Biological age in diabetes and precision medicine. Aging\| PubMed ID: 35666709	2022
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype. Frontiers in endocrinology\| PubMed ID: 35909566	2022
PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36375063	2022
Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity. Aging\| PubMed ID: 36640267	2023
Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications. Diabetes & metabolism journal\| PubMed ID: 36872059	2023
"FunDNAmethyl" Mechanism for Developmental Restriction of a β-Cell Subpopulation. Diabetes\| PubMed ID: 37146281	2023
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells. Frontiers in endocrinology\| PubMed ID: 37441495	2023
Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies. Frontiers in endocrinology\| PubMed ID: 37720527	2023
Interaction between Autophagy and Senescence in Pancreatic Beta Cells. Biology\| PubMed ID: 37759604	2023
Heterogeneity of increased biological age in type 2 diabetes correlates with differential tissue DNA methylation, biological variables, and pharmacological treatments. GeroScience\| PubMed ID: 37987887	2024
Editorial: Cellular senescence in diabetes: from markers to mechanisms and therapies. Frontiers in endocrinology\| PubMed ID: 38164496	2023
SenNet recommendations for detecting senescent cells in different tissues. Nature reviews. Molecular cell biology\| PubMed ID: 38831121	2024
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence. Nature metabolism\| PubMed ID: 39317751	2024
A Standardized Clinical Case-Based Assessment for Evaluating Medical Students' Oral Spanish Communication Skills. MedEdPORTAL : the journal of teaching and learning resources\| PubMed ID: 40248665	2025
A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling. bioRxiv : the preprint server for biology\| PubMed ID: 40654723	2025