procurement-parathyroid-glands-from-living-donor-pigs-ex-vivo

Procurement of Parathyroid Glands from Living Donor Pigs and <em>Ex Vivo</em> Identification

Hypoparathyroidism, often resulting from surgical complications, severely disrupts calcium homeostasis, leading to disabling symptoms. Current treatments ...

UNIVERSITY OF LILLE

In animal research, obtaining efficient and constant pain control is regulatory but challenging. The gold standard pain management consists of opioid analgesic administration, such as buprenorphine or fentanyl extended-release patches. However, as in all drugs with a short half-life time, repeated buprenorphine administrations are needed, leading to multiple injections that affect the research protocol. On the other hand, fentanyl patch efficacy is discussed in some species. These elements highlight the need of an optimal formulation of analgesic drugs for laboratory animals. In this study, we investigated how Recuvyra®, a fentanyl transdermal solution (FTS), validated in dog perioperative pain management, could provide sustained analgesia after a single topical administration in pigs in a surgical context.

Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs.

Because rodents are too small to perform surgical procedures on people, large mammals are frequently required for surgical studies. Because of its similar overall anatomy and physiology, the pig has a very high translational value and is thus frequently used as the first choice in surgical research.

Article	Year
Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes\| PubMed ID: 34167112	2021
Pig Models in Translational Surgery. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes\| PubMed ID: 40319887	2025

Rebecca Goutchtat

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