Karl Riabowol

Department of Biochemistry & Molecular Biology and Oncology, University of Calgary

Research Area

Biography

Karl Riabowol has not added Biography.
If you are Karl Riabowol and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo. PloS one\| PubMed ID: 39787145	2025
Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells. Molecular and cellular biology\| PubMed ID: 9584157	1998
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Molecular and cellular biology\| PubMed ID: 10805724	2000
UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences. Nucleic acids research\| PubMed ID: 11353074	2001
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11481424	2001
Human ING1 proteins differentially regulate histone acetylation. The Journal of biological chemistry\| PubMed ID: 12015309	2002
ING1 isoforms differentially affect apoptosis in a cell age-dependent manner. Cancer research\| PubMed ID: 12154053	2002
A novel transcriptional inhibitory element differentially regulates the cyclin D1 gene in senescent cells. The Journal of biological chemistry\| PubMed ID: 12464605	2003
ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction. Cancer letters\| PubMed ID: 12637159	2003
ING1 represses transcription by direct DNA binding and through effects on p53. Cancer research\| PubMed ID: 14522900	2003
Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers. Cancers\| PubMed ID: 40149370	2025
Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14676120	2003
Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Molecular and cellular biology\| PubMed ID: 15282327	2004
Murine models of life span extension. Science of aging knowledge environment : SAGE KE\| PubMed ID: 15295107	2004
Phylogenetic analysis of the ING family of PHD finger proteins. Molecular biology and evolution\| PubMed ID: 15356280	2005
Function of the ING family of PHD proteins in cancer. The international journal of biochemistry & cell biology\| PubMed ID: 15743678	2005
Paternal age is positively linked to telomere length of children. Aging cell\| PubMed ID: 15771613	2005
Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis. Experimental cell research\| PubMed ID: 16516887	2006
Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. Molecular and cellular biology\| PubMed ID: 16581770	2006
Chromatin modification and senescence: linkage by tumor suppressors? Rejuvenation research\| PubMed ID: 16608399	2006
HSP70 induction by ING proteins sensitizes cells to tumor necrosis factor alpha receptor-mediated apoptosis. Molecular and cellular biology\| PubMed ID: 17030616	2006
Acceleration of telomere loss by chemotherapy is greater in older patients with locally advanced head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17085644	2006
After a decade of study-ING, a PHD for a versatile family of proteins. Trends in biochemical sciences\| PubMed ID: 17949986	2007
ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. The Journal of biological chemistry\| PubMed ID: 18334480	2008
ING1 protein targeting to the nucleus by karyopherins is necessary for activation of p21. Biochemical and biophysical research communications\| PubMed ID: 18655775	2008
ING1a expression increases during replicative senescence and induces a senescent phenotype. Aging cell\| PubMed ID: 18691180	2008
Interspecies data mining to predict novel ING-protein interactions in human. BMC genomics\| PubMed ID: 18801192	2008
Tethering by lamin A stabilizes and targets the ING1 tumour suppressor. Nature cell biology\| PubMed ID: 18836436	2008
The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway. Genetics\| PubMed ID: 19015549	2009
ING function in apoptosis in diverse model systems. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 19234528	2009
Signaling pathways of the ING proteins in apoptosis. Current drug targets\| PubMed ID: 19442111	2009
REAP: A two minute cell fractionation method. BMC research notes\| PubMed ID: 21067583	2010
Domain recognition of the ING1 tumor suppressor by a panel of monoclonal antibodies. Hybridoma (2005)\| PubMed ID: 21707358	2011
The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination. PloS one\| PubMed ID: 21731648	2011
Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition. Cancer cell international\| PubMed ID: 22206574	2011
Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation. PloS one\| PubMed ID: 22808232	2012
ING1 and 5-azacytidine act synergistically to block breast cancer cell growth. PloS one\| PubMed ID: 22916295	2012
Telomere length correlates with life span of dog breeds. Cell reports\| PubMed ID: 23260664	2012
RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators. The Biochemical journal\| PubMed ID: 23445221	2013
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS biology\| PubMed ID: 23472054	2013
Src regulates the activity of the ING1 tumor suppressor. PloS one\| PubMed ID: 23585863	2013
Gender and telomere length: systematic review and meta-analysis. Experimental gerontology\| PubMed ID: 24365661	2014
Survivin as a preferential target for cancer therapy. International journal of molecular sciences\| PubMed ID: 24531137	2014
Keep-ING balance: tumor suppression by epigenetic regulation. FEBS letters\| PubMed ID: 24632289	2014
SUMOylation of the ING1b tumor suppressor regulates gene transcription. Carcinogenesis\| PubMed ID: 24903338	2014
Tumor cell apoptosis mediated by cytoplasmic ING1 is associated with improved survival in oral squamous cell carcinoma patients. Oncotarget\| PubMed ID: 24912621	2014
Reduced ING1 levels in breast cancer promotes metastasis. Oncotarget\| PubMed ID: 24962136	2014
ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal. European journal of cell biology\| PubMed ID: 25819753	2015
Rapid Isolation of Nuclei from Cells In Vitro. Cold Spring Harbor protocols\| PubMed ID: 26240403	2015
Isolation of Pure Nuclei Using a Sucrose Method. Cold Spring Harbor protocols\| PubMed ID: 26240404	2015
Isolation of Nuclei. Cold Spring Harbor protocols\| PubMed ID: 26240413	2015
Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival. Molecular cancer\| PubMed ID: 26306560	2015
Aging with ING: a comparative study of different forms of stress induced premature senescence. Oncotarget\| PubMed ID: 26439691	2015
ING3 is associated with increased cell invasion and lethal outcome in ERG-negative prostate cancer patients. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26803516	2016
Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer. Oncotarget\| PubMed ID: 27741524	2016
ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization. Nucleic acids research\| PubMed ID: 27903908	2017
DisorderING promotes epigenetic order. FEBS letters\| PubMed ID: 28090648	2017
ING3 promotes prostate cancer growth by activating the androgen receptor. BMC medicine\| PubMed ID: 28511652	2017
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British journal of cancer\| PubMed ID: 29381681	2018
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. Oncogene\| PubMed ID: 29755129	2018
The ING1a model of rapid cell senescence. Mechanisms of ageing and development\| PubMed ID: 29928906	2019
Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. Bio-protocol\| PubMed ID: 30515449	2018
Biological Functions of the ING Proteins. Cancers\| PubMed ID: 31752342	2019
Telomere analysis using 3D fluorescence microscopy suggests mammalian telomere clustering in hTERT-immortalized Hs68 fibroblasts. Communications biology\| PubMed ID: 31815205	2019
Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death. Cancers\| PubMed ID: 31905726	2019
Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging. Frontiers in cell and developmental biology\| PubMed ID: 32039197	2019
Senescence and Apoptosis: Architects of Mammalian Development. Frontiers in cell and developmental biology\| PubMed ID: 33537310	2020
Fluorescence microscopy methods for examining telomeres during cell aging. Ageing research reviews\| PubMed ID: 33744488	2021
Histone Acetyltransferases and Stem Cell Identity. Cancers\| PubMed ID: 34067525	2021
ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat. European journal of cell biology\| PubMed ID: 37459799	2023
L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand. Cell death discovery\| PubMed ID: 40195325	2025
hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan. Aging cell\| PubMed ID: 40371663	2025
Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells. Histochemistry and cell biology\| PubMed ID: 40402282	2025