Ki-Young Lee

Department of Cell Biology & Anatomy, University of Calgary

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Controversies over p25 in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 12214136	2002
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain. Oncogene\| PubMed ID: 12569370	2003
Outer dense fibers serve as a functional target for Cdk5.p35 in the developing sperm tail. The Journal of biological chemistry\| PubMed ID: 14581463	2004
Cdk7 functions as a cdk5 activating kinase in brain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 14586172	2003
L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. Oncogene\| PubMed ID: 15208659	2004
GTP-dependent secretion from neutrophils is regulated by Cdk5. The Journal of biological chemistry\| PubMed ID: 15492003	2004
Extraneuronal roles of cyclin-dependent kinase 5. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 16998837	2006
ODF1 phosphorylation by Cdk5/p35 enhances ODF1-OIP1 interaction. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 17762160	2007
Tyrosine hydroxylase expression and Cdk5 kinase activity in ataxic cerebellum. Molecular and cellular biochemistry\| PubMed ID: 18618229	2008
Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. The Journal of pathology\| PubMed ID: 19479822	2009
Down-regulation of ING4 is associated with initiation and progression of lung cancer. Histopathology\| PubMed ID: 20716169	2010
Novel alternatively spliced variant form of human CDK5RAP2. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21346412	2011
Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. Journal of cellular physiology\| PubMed ID: 21465480	2012
Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions. Molecules and cells\| PubMed ID: 21533545	2011
Clues for c-Yes involvement in the cell cycle and cytokinesis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21566460	2011
Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression. PloS one\| PubMed ID: 22319568	2012
Viewpoint: Crosstalks between neurofibrillary tangles and amyloid plaque formation. Ageing research reviews\| PubMed ID: 22728532	2013
Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22987154	2012
Thrombin enhances NGF-mediated neurite extension via increased and sustained activation of p44/42 MAPK and p38 MAPK. PloS one\| PubMed ID: 25061982	2014
Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells. Journal of medical genetics\| PubMed ID: 25537274	2015
Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2. PloS one\| PubMed ID: 26550838	2015
Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition. PloS one\| PubMed ID: 26618703	2015
Enhancement of Peripheral Nerve Regrowth by the Purine Nucleoside Analog and Cell Cycle Inhibitor, Roscovitine. Frontiers in cellular neuroscience\| PubMed ID: 27799897	2016
Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice. Journal of lipid research\| PubMed ID: 28536109	2017
Integration of a bacterial gene sequence into a chronic eosinophilic leukemia patient's genome as part of a fusion gene linker. Biomarker research\| PubMed ID: 28593047	2017
Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore. Oncogene\| PubMed ID: 29348461	2018
Neutrophil TLR4 and PKR are targets of breast cancer cell glycosaminoglycans and effectors of glycosaminoglycan-induced APRIL secretion. Oncogenesis\| PubMed ID: 29904116	2018
Targeting Cdk5 for killing of breast cancer cells via perturbation of redox homeostasis. Oncoscience\| PubMed ID: 30035173	2018
HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway. Blood\| PubMed ID: 30819925	2019
ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals. Oxidative medicine and cellular longevity\| PubMed ID: 31217841	2019
mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca uptake. Oncogene\| PubMed ID: 32024968	2020
D,L-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca release and decrease in Ca efflux, elevating [Ca]. Scientific reports\| PubMed ID: 33441856	2021
Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 33725591	2021
CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3β/β-catenin-WIP1 pathway. Cell death & disease\| PubMed ID: 34930892	2021
Cdk5 regulates IP3R1-mediated Ca dynamics and Ca-mediated cell proliferation. Cellular and molecular life sciences : CMLS\| PubMed ID: 36001172	2022
Requirement for ER-mitochondria Ca transfer, ROS production and mPTP formation in L-asparaginase-induced apoptosis of acute lymphoblastic leukemia cells. Frontiers in cell and developmental biology\| PubMed ID: 36895789	2023
Editorial: Biomarkers and therapeutic strategies in acute lymphoblastic leukemia. Frontiers in cell and developmental biology\| PubMed ID: 37266454	2023
PKA inhibition is a central step in D,L-methadone-induced ER Ca release and subsequent apoptosis in acute lymphoblastic leukemia. Frontiers in cell and developmental biology\| PubMed ID: 38721527	2024
PKA inhibition kills L-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients. Cell death discovery\| PubMed ID: 38802344	2024
L-asparaginase induces IP3R-mediated ER Ca release by targeting µ-OR1 and PAR2 and kills acute lymphoblastic leukemia cells. Cell death discovery\| PubMed ID: 39147734	2024
L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand. Cell death discovery\| PubMed ID: 40195325	2025