an-experimentally-validated-mathematical-model-axial-spinal

An Experimentally Validated Mathematical Model of Axial Spinal Compression to Visualize Vertebral Compression Fracture

The finite element analysis (FEA) model established in this study predicts the mechanical behavior of a vertebral body under pure compression loading. ...

Rosalind Franklin University of Medicine and Science

Anterior cruciate ligament (ACL) tears frequently cause chronic inflammation and posttraumatic osteoarthritis (PTOA), with therapies failing to resolve persistent post-injury inflammation. Specialized pro-resolving mediators (SPMs), including Maresin1 (MaR1), show promise in resolving inflammation and promoting tissue repair. However, their role in PTOA remains underexplored. This study investigated inflammatory markers and MaR1 dynamics post-ACL injury, the role of the MaR1 receptor Leucine-rich Repeat-containing G protein-coupled receptor 6 (LGR6) in PTOA, and MaR1's therapeutic potential in a mouse ACL transection (ACLT) model.

Julie Mekhail

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