comparative-study-on-polysaccharide-contents-antioxidant-activities

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

This paper reports a well-designed and in-depth comparative study on the polysaccharide yields, contents, and antioxidant activities of two Hippophae ...

Chengdu University of Traditional Chinese Medicine

The mutational status of alpha-thalassemia X-linked intellectual disability () is an important indicator for the treatment and prognosis of high-grade gliomas, but reliable  testing currently requires invasive procedures. The objective of this study was to develop a clinical trait-imaging fusion model that combines preoperative magnetic resonance imaging (MRI) radiomics and deep learning (DL) features with clinical variables to predict  status in isocitrate dehydrogenase ()-mutant high-grade astrocytoma.

A fusion model integrating magnetic resonance imaging radiomics and deep learning features for predicting alpha-thalassemia X-linked intellectual disability mutation status in isocitrate dehydrogenase-mutant high-grade astrocytoma: a multicenter study.

: This study aimed to characterize the physicochemical properties and antioxidant activities of polysaccharides from Aconitum pendulum Bush processed through different methods (the polysaccharide from A. pendulum (DT), the polysaccharide from A. pendulum processed with zanba (Z-DT), the polysaccharide from A. pendulum processed with highland barley wine (Q-DT), and the polysaccharide from A. pendulum processed with hezi (H-DT)). Additionally, the research focused on optimizing the hot water extraction process for DT using response surface methodology (RSM) to enhance extraction efficiency and establish a scientific basis for pharmaceutical applications. : The physicochemical properties and antioxidant activities of the four polysaccharides were systematically evaluated. RSM with a 17-run Box-Behnken design was employed to investigate the extraction process, examining three factors: extraction runs, liquid-solid ratio, and extraction time. : The physicochemical properties and antioxidant assays demonstrated that the DT exhibited significantly higher properties. The factors influencing the extraction process were ranked as extraction runs > liquid-solid ratio > extraction time. The optimal conditions for DT were a liquid-solid ratio of 25 mL/g, extraction time of 2.5 h, and four extraction runs, yielding a sugar content of 63.4%. Under these conditions, the extraction rate of DT was significantly higher than before optimization. : The study demonstrated distinct structural features among the four polysaccharides, providing a scientific framework for their potential pharmaceutical applications. What's more, the optimized hot water extraction protocol for DT was validated for high extraction rate and reproducibility.

Method-Driven Physicochemical Profiling of  Bush Polysaccharides and Optimization of Extraction Protocols.

The seeds of Citrus reticulata Blanco (Rutaceae) (SCR), a traditional Chinese medicine derived from Citrus, is known for its diverse bioactivities, including potential anti-breast cancer effects, but the mechanism of action remains unclear.

Article	Year
A fusion model integrating magnetic resonance imaging radiomics and deep learning features for predicting alpha-thalassemia X-linked intellectual disability mutation status in isocitrate deh... Quantitative imaging in medicine and surgery\| PubMed ID: 38223098	2024
Method-Driven Physicochemical Profiling of Bush Polysaccharides and Optimization of Extraction Protocols. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 40430577	2025
Two natural products from the seeds of Blanco (Rutaceae) inhibit estrogen biosynthesis by regulating the PI3K-aromatase pathway. Frontiers in pharmacology\| PubMed ID: 40575782	2025

Xing Yang

Biography

JoVE Journal Publications

Other Publications