retrospective-evaluation-synthetic-ligament-based-revision-anterior

Retrospective Evaluation of Synthetic Ligament-Based Revision of Anterior Cruciate Ligament Reconstruction for Postoperative Re-Rupture

Re-rupture following anterior cruciate ligament (ACL) reconstruction remains a challenging complication, necessitating effective revision strategies. To ...

Sixth Affiliated Hospital of Xinjiang Medical University

Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical and psychological harm and a series of socioeconomic problems. Although neurons in the spinal cord need neurotrophic factors for their survival and development to reestablish their connections with their original targets, endogenous neurotrophic factors are scarce and the sustainable delivery of exogeneous neurotrophic factors is challenging. The widely studied neurotrophic factors such as brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, ciliary neurotrophic factor, basic fibroblast growth factor, and glial cell-derived neurotrophic factor have a relatively short cycle that is not sufficient enough for functionally significant neural regeneration after SCI. In the past decades, scholars have tried a variety of cellular and viral vehicles as well as tissue engineering scaffolds to safely and sustainably deliver those necessary neurotrophic factors to the injury site, and achieved satisfactory neural repair and functional recovery on many occasions. Here, we review the neurotrophic factors that have been used in trials to treat SCI, and vehicles that were commonly used for their sustained delivery.

Sustained delivery of neurotrophic factors to treat spinal cord injury.

We sought to analyze the preventive effect of local vancomycin powder application on surgical site infection (SSI) in spinal surgeries and provide the basis for future clinical practice.

Prophylactic Application of Vancomycin Powder in Preventing Surgical Site Infections After Spinal Surgery.

Pedicle screw loosening is one of the main complications after pedicle screw fixation. However, there are few reliable measures for prediction of screw loosening. The current study was carried out to find an effective method to use preoperative CT scanning as a predictor of screw loosening in the elderly patients and provide guidance for preoperative surgical planning.

Computed Tomography-Based Prediction of Lumbar Pedicle Screw Loosening.

One of the most common issues following pedicle screw fixation is pedicle screw loosening. There are, however, few trustworthy methods for predicting screw loosening. The goal of the current study was to identify an efficient technique for using preoperative CT scanning to predict screw loosening in older patients and to offer recommendations for preoperative surgical planning.

Prediction of Lumbar Pedicle Screw Loosening Using Hounsfield Units in Computed Tomography.

By reviewing the literature analyzing vancomycin powder for preventive surgery, the effect of this method on reducing the infection rate after TJA was systematically evaluated to provide a basis for future clinical work.

Prophylactic use of vancomycin powder on postoperative infection after total joint arthroplasty.

This study analyzed the current research hotspots and future development trends of the therapeutic effects of microRNA on PNI axonal regeneration through bibliometric methods. Moreover, the current advantages and disadvantages of this field as well as future development prospects are discussed in depth.

The role of microRNAs in axon regeneration after peripheral nerve injury: a bibliometric analysis.

In articular cartilage defect, particularly in arthroscopy, regenerative hydrogels are urgently needed. It should be able to firmly adhere to the cartilage tissue and maintain sufficient mechanical strength to withstand approximately 10 kPa of arthroscopic hydraulic flushing. In this study, we report a carbene-mediated ultra adhesive hybrid hydrogel paints for arthroscopic cartilage repair, which combined the photo initiation of double crosslinking system with the addition of diatomite, as a further reinforcing agent and biological inorganic substances. The double network consisting of ultraviolet initiated polymerization of hyaluronic acid methacrylate (HAMA) and carbene insertion chemistry of diazirine-grafted gelatin (GelDA) formed an ultra-strong adhesive hydrogel paint (H2G5DE). Diatomite helped the H2G5DE hydrogel paint firmly adhere to the cartilage defect, withstanding nearly 100 kPa of hydraulic pressure, almost 10 times that in clinical arthroscopy. Furthermore, the H2G5DE hydrogel supported cell growth, proliferation, and migration, thus successfully repairing cartilage defects. Overall, this study demonstrates a proof-of-concept of ultra-adhesive polysaccharide hydrogel paints, which can firmly adhere to the articular cartilage defects, can resist continuous hydraulic pressure, can promote effective cartilage regeneration, and is very suitable for minimally invasive arthroscopy.

Carbene-mediated gelatin and hyaluronic acid hydrogel paints with ultra adhesive ability for arthroscopic cartilage repair.

While observational research has highlighted a possible link between ankylosing spondylitis (AS) and type 2 diabetes (T2DM), the quality of evidence remains limited, and the causal relationship is yet to be established. This study aims to explore the causal link between AS and T2DM, as well as its impact on traits related to glucose metabolism.

The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis.

Anterior cruciate ligament (ACL) reconstruction remains the gold standard but carries donor-site morbidity and prolonged recovery. Modern ACL repair techniques theoretically preserve native proprioception and enable faster rehabilitation. We hypothesized that modern ACL repair would demonstrate non-inferior clinical outcomes compared to reconstruction.This meta-analysis compares clinical outcomes of primary repair versus autograft reconstruction.

Article	Year
Sustained delivery of neurotrophic factors to treat spinal cord injury. Translational neuroscience\| PubMed ID: 34900347	2021
Prophylactic Application of Vancomycin Powder in Preventing Surgical Site Infections After Spinal Surgery. World neurosurgery\| PubMed ID: 36529431	2023
Computed Tomography-Based Prediction of Lumbar Pedicle Screw Loosening. BioMed research international\| PubMed ID: 36743516	2023
Prediction of Lumbar Pedicle Screw Loosening Using Hounsfield Units in Computed Tomography. Current medical imaging\| PubMed ID: 37170978	2024
Prophylactic use of vancomycin powder on postoperative infection after total joint arthroplasty. BMC musculoskeletal disorders\| PubMed ID: 38229109	2024
The role of microRNAs in axon regeneration after peripheral nerve injury: a bibliometric analysis. Frontiers in neurology\| PubMed ID: 38510377	2024
Carbene-mediated gelatin and hyaluronic acid hydrogel paints with ultra adhesive ability for arthroscopic cartilage repair. International journal of biological macromolecules\| PubMed ID: 38876236	2024
The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis. Frontiers in endocrinology\| PubMed ID: 39649224	2024
ACL repair vs. reconstruction: a meta-analysis of outcomes across different tear characteristics. BMC surgery\| PubMed ID: 40764551	2025

Li Shu

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