network-pharmacological-analysis-tcm-formulae-based-on-syndrome

Network Pharmacological Analysis of TCM Formulae Based on the Syndrome Ontology and Multidimensional Quantitative Association Computing Platform

Current network pharmacology methods for TCM formulae predict potential active ingredients and mechanisms of action for specific diseases by constructing ...

Sichuan University

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education

Natural products isolated from Chinese medicinal herbs are useful sources of new drugs for cancer therapy. Tubeimoside-1 (TBMS1) is a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae). Studies have shown that TBMS1 has anticancer effects in various human cancer cell lines. However, the effect of TBMS1 on human gastric cancer cells is unknown. In the present study, it was observed that TBMS1 inhibited BGC823 gastric cancer cell proliferation in a concentration- and time-dependent manner. Fluorescent microscopy and flow cytometric analysis showed that TBMS1 induced BGC823 cell apoptosis in a concentration-dependent manner. Western blot analysis also showed that TBMS1 induced apoptosis by regulation of the Bcl-2 gene family in BGC823 cells. These findings indicate that TBMS1 may be developed as a possible therapeutic agent for the management of gastric cancer.

Effects of tubeimoside-1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro.

Colon cancer is the third most common cancer in the world. The overexpression of tissue factor (TF) in colon cancer cells makes it an ideal target for colon cancer therapy. The purpose of the present study was to develop a TF-targeting energized fusion protein, mlFVII-LDP-AE, which is composed of a mouse Factor VII light chain (mlFVII) as the targeting domain conjugated to the highly cytotoxic antibiotic lidamycin (LDM, LDP-AE) as the effector domain. The potential efficacy of mlFVII-LDP-AE for mouse colon cancer therapy was tested in a mouse colon cancer subcutaneous xenograft model and a live metastasis model in BALB/c mice. mlFVII-LDP-AE showed a tumor growth inhibition rate of 91.2% (at a dose of 0.8 mg/kg) and a tumor metastasis inhibition rate of 84.7% (at a dose of 0.6 mg/kg). The results showed that mlFVII-LDP-AE was able to effectively inhibit the growth and metastasis of mouse colon cancer. As human TF and FVII have features similar to those of mice, human FVII light chain (hlFVII)-targeted LDM (hlFVII-LDP-AE) may be expected to have therapeutic potential for human colon cancer.

Tissue factor-targeted lidamycin inhibits growth and metastasis of colon carcinoma.

Fetus in fetu is a rare congenital anomaly and is defined as a monozygotic twin incorporated into the abdomen of its sibling during development. Fetus in fetu is often overlooked in the differential diagnosis of an abdominal mass. Unlike teratomas, fetus in fetu is a benign disorder.

Fetus in fetu: two case reports and literature review.

The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.

To evaluate insulin injection knowledge, attitudes, and practices of nurses across China in order to provide reference for the formulation of a national unified standard of insulin injection practice and the targeted implementation of standardized training on insulin injection for nurses.

Insulin Injection Knowledge, Attitudes, and Practices of Nurses in China: A Cross-Sectional Nationwide Study.

Diabetes remains a major global health challenge in China. Artificial intelligence (AI) has demonstrated considerable potential in improving diabetes management. This study aimed to assess healthcare providers' perceptions regarding AI in diabetes care across China.

Article	Year
Effects of tubeimoside-1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro. Oncology letters\| PubMed ID: 23425861	2013
Tissue factor-targeted lidamycin inhibits growth and metastasis of colon carcinoma. Oncology letters\| PubMed ID: 24137414	2013
Fetus in fetu: two case reports and literature review. BMC pediatrics\| PubMed ID: 24693883	2014
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England)\| PubMed ID: 33428867	2021
Insulin Injection Knowledge, Attitudes, and Practices of Nurses in China: A Cross-Sectional Nationwide Study. Diabetes therapy : research, treatment and education of diabetes and related disorders\| PubMed ID: 34350563	2021
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England)\| PubMed ID: 37321233	2023
Healthcare providers' perceptions of artificial intelligence in diabetes care: A cross-sectional study in China. International journal of nursing sciences\| PubMed ID: 40529456	2025

Li Caihong

Biography

JoVE Journal Publications

Other Publications