Peter T. C. So

Department of Mechanical Engineering, Massachusetts Institute of Technology

Affiliated withMassachusetts Institute of Technology

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Fast fluorescence laser tracking microrheometry. I: instrument development. Biophysical journal\| PubMed ID: 17965137	2008
Lateral resolution enhancement with standing evanescent waves. Optics letters\| PubMed ID: 18059777	2000
Spectrally resolved fluorescence correlation spectroscopy based on global analysis. Analytical chemistry\| PubMed ID: 18351754	2008
Resolution enhancement in standing-wave total internal reflection microscopy: a point-spread-function engineering approach. Journal of the Optical Society of America. A, Optics, image science, and vision\| PubMed ID: 11688874	2001
Two-photon excitation fluorescence microscopy. Annual review of biomedical engineering\| PubMed ID: 11701518	2000
Topographic heterogeneity in transdermal transport revealed by high-speed two-photon microscopy: determination of representative skin sample sizes. The Journal of investigative dermatology\| PubMed ID: 12060407	2002
Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy. The Journal of investigative dermatology\| PubMed ID: 12603859	2003
In vivo and ex vivo tissue applications of two-photon microscopy. Methods in enzymology\| PubMed ID: 12624925	2003
Evaluation of fluorescent probe surface intensities as an indicator of transdermal permeant distributions using wide-area two-photon fluorescence microscopy. Journal of pharmaceutical sciences\| PubMed ID: 14603481	2003
Mechanotransduction through growth-factor shedding into the extracellular space. Nature\| PubMed ID: 15103386	2004
Two-photon tissue cytometry. Methods in cell biology\| PubMed ID: 15603421	2004
Two-photon 3-D mapping of ex vivo human skin endogenous fluorescence species based on fluorescence emission spectra. Journal of biomedical optics\| PubMed ID: 15910090	2005
Extended resolution wide-field optical imaging: objective-launched standing-wave total internal reflection fluorescence microscopy. Optics letters\| PubMed ID: 16599220	2006
Comparing the quantification of Forster resonance energy transfer measurement accuracies based on intensity, spectral, and lifetime imaging. Journal of biomedical optics\| PubMed ID: 16822067	2006
Investigating mechanisms of collagen thermal denaturation by high resolution second-harmonic generation imaging. Biophysical journal\| PubMed ID: 16829565	2006
Frequency domain lifetime and spectral imaging microscopy. Microscopy research and technique\| PubMed ID: 16924635	2006
Detecting single quantum dot motion with nanometer resolution for applications in cell biology. IEEE transactions on nanobioscience\| PubMed ID: 17181023	2006
Multifunctional imaging of endogenous contrast by simultaneous nonlinear and optical coherence microscopy of thick tissues. Microscopy research and technique\| PubMed ID: 17323366	2007
High-resolution whole organ imaging using two-photon tissue cytometry. Journal of biomedical optics\| PubMed ID: 17343490	2007
Two-dimensional standing wave total internal reflection fluorescence microscopy: superresolution imaging of single molecular and biological specimens. Biophysical journal\| PubMed ID: 17483188	2007
Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer. The Journal of investigative dermatology\| PubMed ID: 17554365	2007
Three-dimensional tissue cytometer based on high-speed multiphoton microscopy. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17929292	2007
Fast fluorescence laser tracking microrheometry, II: quantitative studies of cytoskeletal mechanotransduction. Biophysical journal\| PubMed ID: 18424489	2008
Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18647827	2008
Ultrafast optical pulse delivery with fibers for nonlinear microscopy. Microscopy research and technique\| PubMed ID: 18816597	2008
Quantitative morphometric measurements using site selective image cytometry of intact tissue. Journal of the Royal Society, Interface / the Royal Society\| PubMed ID: 19049958	2009
Multiscale structural analysis of mouse lingual myoarchitecture employing diffusion spectrum magnetic resonance imaging and multiphoton microscopy. Journal of biomedical optics\| PubMed ID: 19123652	2008
Multifocal multiphoton microscopy based on multianode photomultiplier tubes. Optics express\| PubMed ID: 19547526	2007
Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves. Optics letters\| PubMed ID: 19649099	2009
Depth resolved wide field illumination for biomedical imaging and fabrication. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 19964287	2009
An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20056713	2010
Surface-plasmon-coupled emission microscopy with a spiral phase plate. Optics letters\| PubMed ID: 20160803	2010
Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imaging. Annals of biomedical engineering\| PubMed ID: 20461466	2010
High-throughput three-dimensional lithographic microfabrication. Optics letters\| PubMed ID: 20479822	2010
An optical method to quantify the density of ligands for cell adhesion receptors in three-dimensional matrices. Journal of the Royal Society, Interface\| PubMed ID: 20671067	2010
Shack-Hartmann wavefront-sensor-based adaptive optics system for multiphoton microscopy. Journal of biomedical optics\| PubMed ID: 20799824	2010
Quantifying the dynamics of bacterial secondary metabolites by spectral multiphoton microscopy. ACS chemical biology\| PubMed ID: 21671613	2011
Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis. PloS one\| PubMed ID: 22073152	2011
Improving signal-to-noise ratio of structured light microscopy based on photon reassignment. Biomedical optics express\| PubMed ID: 22254180	2012
Advances in optics for biotechnology, medicine and surgery. Biomedical optics express\| PubMed ID: 22435099	2012
Methodological considerations for global analysis of cellular FLIM/FRET measurements. Journal of biomedical optics\| PubMed ID: 22463045	2012
Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and in skin. Biomaterials\| PubMed ID: 22483241	2012
Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex. Neuron\| PubMed ID: 22542188	2012
Coupled and uncoupled dipole models of nonlinear scattering. Optics express\| PubMed ID: 23187400	2012
3D-resolved fluorescence and phosphorescence lifetime imaging using temporal focusing wide-field two-photon excitation. Optics express\| PubMed ID: 23187477	2012
Three dimensional HiLo-based structured illumination for a digital scanned laser sheet microscopy (DSLM) in thick tissue imaging. Optics express\| PubMed ID: 23262684	2012
On the correction of errors in some multiple particle tracking experiments. Applied physics letters\| PubMed ID: 23405035	2013
Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fib... Human gene therapy\| PubMed ID: 23527815	2013
Temporally focused wide-field two-photon microscopy: paraxial to vectorial. Optics express\| PubMed ID: 23736515	2013
Improvement of axial resolution and contrast in temporally focused widefield two-photon microscopy with structured light illumination. Biomedical optics express\| PubMed ID: 23847726	2013
Parallel super-resolution imaging. Nature methods\| PubMed ID: 23900251	2013
The challenge of connecting the dots in the B.R.a.I.N. Neuron\| PubMed ID: 24139032	2013
Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy. Methods (San Diego, Calif.)\| PubMed ID: 24184188	2014
High-throughput nonlinear optical microscopy. Biophysical journal\| PubMed ID: 24359736	2013
Measurement of the time-resolved reflection matrix for enhancing light energy delivery into a scattering medium. Physical review letters\| PubMed ID: 24483661	2013
qFibrosis: a fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients. Journal of hepatology\| PubMed ID: 24583249	2014
Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification. Scientific reports\| PubMed ID: 24717650	2014
Reassignment of scattered emission photons in multifocal multiphoton microscopy. Scientific reports\| PubMed ID: 24898470	2014
Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS genetics\| PubMed ID: 24901438	2014
Application of Multiphoton Microscopy in Dermatological Studies: a Mini-Review. Journal of innovative optical health sciences\| PubMed ID: 25075226	2014
Improving femtosecond laser pulse delivery through a hollow core photonic crystal fiber for temporally focused two-photon endomicroscopy. Scientific reports\| PubMed ID: 25316120	2014
Spectral-resolved multifocal multiphoton microscopy with multianode photomultiplier tubes. Optics express\| PubMed ID: 25321515	2014
Three-dimensional image cytometer based on widefield structured light microscopy and high-speed remote depth scanning. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 25352187	2015
Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry. Biomedical optics express\| PubMed ID: 25360367	2014
Dynamic speckle illumination wide-field reflection phase microscopy. Optics letters\| PubMed ID: 25361156	2014
Depth-selective microscopic observation of a photomobile liquid crystal polymer under UV illumination. Physical chemistry chemical physics : PCCP\| PubMed ID: 25384880	2014
Diffraction optical tomography using a quantitative phase imaging unit. Optics letters\| PubMed ID: 25503034	2014
Differential remodeling of extracellular matrices by breast cancer initiating cells. Journal of biophotonics\| PubMed ID: 25597396	2015
3D-resolved targeting of photodynamic therapy using temporal focusing. Laser physics letters\| PubMed ID: 25620902	2014
High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap. Nano letters\| PubMed ID: 25646716	2015
Thermomechanical Actuator-Based Three-Axis Optical Scanner for High-Speed Two-Photon Endomicroscope Imaging. Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems\| PubMed ID: 25673965	2014
Talbot holographic illumination nonscanning (THIN) fluorescence microscopy. Laser & photonics reviews\| PubMed ID: 25678936	2014
Objective, comparative assessment of the penetration depth of temporal-focusing microscopy for imaging various organs. Journal of biomedical optics\| PubMed ID: 25844509	2015
Non-descanned multifocal multiphoton microscopy with a multianode photomultiplier tube. AIP advances\| PubMed ID: 25874160	2015
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface. Journal of biophotonics\| PubMed ID: 26131709	2015
In Situ Quantification of Surface Chemistry in Porous Collagen Biomaterials. Annals of biomedical engineering\| PubMed ID: 26369635	2016
Digital micromirror device-based laser-illumination Fourier ptychographic microscopy. Optics express\| PubMed ID: 26480361	2015
Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26619365	2016
Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo. Neuron\| PubMed ID: 26853302	2016
Pushing phase and amplitude sensitivity limits in interferometric microscopy. Optics letters\| PubMed ID: 27192311	2016
Fluorescent probes for nanoscopy: four categories and multiple possibilities. Journal of biophotonics\| PubMed ID: 27221311	2017
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging. Scientific reports\| PubMed ID: 27283889	2016
Virtual k-Space Modulation Optical Microscopy. Physical review letters\| PubMed ID: 27447529	2016
Raman Spectroscopy Differentiates Each Tissue from the Skin to the Spinal Cord: A Novel Method for Epidural Needle Placement? Anesthesiology\| PubMed ID: 27466032	2016
Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Science advances\| PubMed ID: 27493991	2016
Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27512047	2016
Investigating Effects of Proteasome Inhibitor on Multiple Myeloma Cells Using Confocal Raman Microscopy. Sensors (Basel, Switzerland)\| PubMed ID: 27983660	2016
Modeling the depth-sectioning effect in reflection-mode dynamic speckle-field interferometric microscopy. Optics express\| PubMed ID: 28085800	2017
Superpixel-based segmentation of muscle fibers in multi-channel microscopy. BMC systems biology\| PubMed ID: 28105947	2016
Quantification of labile heme in live malaria parasites using a genetically encoded biosensor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28242687	2017
Digital micromirror device-based common-path quantitative phase imaging. Optics letters\| PubMed ID: 28362789	2017
Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 28370669	2017
Three-dimensional wide-field pump-probe structured illumination microscopy. Optics express\| PubMed ID: 28380860	2017
Large population cell characterization using quantitative phase cytometer. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 28444998	2017
Development of a classification model for non-alcoholic steatohepatitis (NASH) using confocal Raman micro-spectroscopy. Journal of biophotonics\| PubMed ID: 28635128	2017
Label-free characterization of ultra violet-radiation-induced changes in skin fibroblasts with Raman spectroscopy and quantitative phase microscopy. Scientific reports\| PubMed ID: 28883655	2017
Single-shot dual-wavelength interferometric microscopy. Methods (San Diego, Calif.)\| PubMed ID: 29079485	2018
Next-generation optical imaging with short-wave infrared quantum dots. Nature biomedical engineering\| PubMed ID: 29119058	2017
Three-dimensional wide-field pump-probe structured illumination microscopy: erratum. Optics express\| PubMed ID: 29245817	2017
Dynamic spatial filtering using a digital micromirror device for high-speed optical diffraction tomography. Optics express\| PubMed ID: 29328319	2018
Tomographic phase microscopy: principles and applications in bioimaging [Invited]. Journal of the Optical Society of America. B, Optical physics\| PubMed ID: 29386746	2017
Enhanced Axial Resolution of Wide-Field Two-Photon Excitation Microscopy by Line Scanning Using a Digital Micromirror Device. Micromachines\| PubMed ID: 29387484	2017
Near-common-path interferometer for imaging Fourier-transform spectroscopy in wide-field microscopy. Optica\| PubMed ID: 29392168	2017
Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales. Current opinion in biomedical engineering\| PubMed ID: 29392187	2018
Eleven quick tips for running an interdisciplinary short course for new graduate students. PLoS computational biology\| PubMed ID: 29596417	2018
Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing. Analytical and bioanalytical chemistry\| PubMed ID: 30046865	2018
In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy. The Analyst\| PubMed ID: 30070266	2018
Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice. Scientific reports\| PubMed ID: 30108260	2018
Three-dimensional super-resolution high-throughput imaging by structured illumination STED microscopy. Optics express\| PubMed ID: 30119399	2018
Quantitative phase microscopy of red blood cells during planar trapping and propulsion. Lab on a chip\| PubMed ID: 30132501	2018
Absorption by water increases fluorescence image contrast of biological tissue in the shortwave infrared. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30150372	2018
Deep learning enables automated scoring of liver fibrosis stages. Scientific reports\| PubMed ID: 30375454	2018
Scattering reduction by structured light illumination in line-scanning temporal focusing microscopy. Biomedical optics express\| PubMed ID: 30460153	2018
Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation. Optics express\| PubMed ID: 30469763	2018
Low-coherent optical diffraction tomography by angle-scanning illumination. Journal of biophotonics\| PubMed ID: 30597743	2019
Correction to: Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing. Analytical and bioanalytical chemistry\| PubMed ID: 30613839	2019
Functional imaging of visual cortical layers and subplate in awake mice with optimized three-photon microscopy. Nature communications\| PubMed ID: 30635577	2019
Single-Shot Optical Anisotropy Imaging with Quantitative Polarization Interference Microscopy. Laser & photonics reviews\| PubMed ID: 30899335	2018
Reflection phase microscopy using spatio-temporal coherence of light. Optica\| PubMed ID: 31008154	2018
Self-assembling amyloid-like peptides as exogenous second harmonic probes for bioimaging applications. Journal of biophotonics\| PubMed ID: 31162811	2019
Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy. Nature communications\| PubMed ID: 31409824	2019
Scanless volumetric imaging by selective access multifocal multiphoton microscopy. Optica\| PubMed ID: 31984218	2019
Direct observation of glucose fingerprint using in vivo Raman spectroscopy. Science advances\| PubMed ID: 32042901	2020
Analysis of subcutaneous swine fat via deep Raman spectroscopy using a fiber-optic probe. The Analyst\| PubMed ID: 32441278	2020
Dual modal spectroscopic tissue scanner for colorectal cancer diagnosis. Surgical endoscopy\| PubMed ID: 32875410	2021
Spectrochemical Probing of MicroRNA Duplex Using Spontaneous Raman Spectroscopy for Biosensing Applications. Analytical chemistry\| PubMed ID: 32985868	2020
Quantitative third-harmonic generation imaging of mouse visual cortex areas reveals correlations between functional maps and structural substrates. Biomedical optics express\| PubMed ID: 33149977	2020
Increasing the penetration depth of temporal focusing multiphoton microscopy for neurobiological applications. Journal of physics D: Applied physics\| PubMed ID: 33191950	2019
Multiphoton imaging of the effect of monosaccharide diffusion and formation of fluorescent advanced end products in porcine aorta. Journal of biophotonics\| PubMed ID: 33611855	2021
High spatial and temporal resolution synthetic aperture phase microscopy. Advanced photonics\| PubMed ID: 33870104	2020
Tumor cell nuclei soften during transendothelial migration. Journal of biomechanics\| PubMed ID: 33882444	2021
De-scattering with Excitation Patterning enables rapid wide-field imaging through scattering media. Science advances\| PubMed ID: 34233883	2021
Structures and topological defects in pressure-driven lyotropic chromonic liquid crystals. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34446562	2021
In vivo visualization of butterfly scale cell morphogenesis in . Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34845021	2021
Label-free discrimination of tumorigenesis stages using in vitro prostate cancer bone metastasis model by Raman imaging. Scientific reports\| PubMed ID: 35577856	2022
Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome. eLife\| PubMed ID: 35904330	2022
Bendable long graded index lens microendoscopy. Optics express\| PubMed ID: 36258589	2022
Stomach tissue classification using autofluorescence spectroscopy and machine learning. Surgical endoscopy\| PubMed ID: 37055665	2023
Single-Shot Quantitative Polarization Imaging of Complex Birefringent Structure Dynamics. ACS photonics\| PubMed ID: 37292495	2021
De-scattering Deep Neural Network Enables Fast Imaging of Spines through Scattering Media by Temporal Focusing Microscopy. Research square\| PubMed ID: 37333305	2023
Mapping nanoscale topographic features in thick tissues with speckle diffraction tomography. Light, science & applications\| PubMed ID: 37607903	2023
Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues. Journal of biophotonics\| PubMed ID: 37679896	2024
DEEP-squared: deep learning powered De-scattering with Excitation Patterning. Light, science & applications\| PubMed ID: 37704619	2023
Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells. Biosensors\| PubMed ID: 37998148	2023
Multiline Orthogonal Scanning Temporal Focusing (mosTF) Microscopy for Scattering Reduction in High-speed Brain Imaging. Research square\| PubMed ID: 38014213	2023
Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA. Nature biotechnology\| PubMed ID: 38200118	2024
Optical diffraction tomography for assessing single cell models in angular light scattering. Biomedical optics express\| PubMed ID: 38404316	2024
Swept-source Raman spectroscopy of chemical and biological materials. Journal of biomedical optics\| PubMed ID: 38584965	2024
QuATON: Quantization Aware Training of Optical Neurons. Research square\| PubMed ID: 38585742	2024
Multiline orthogonal scanning temporal focusing (mosTF) microscopy for scattering reduction in in vivo brain imaging. Scientific reports\| PubMed ID: 38740797	2024
Two-site microendoscopic imaging probe for simultaneous three-dimensional imaging at two anatomic locations in tissues. Optics letters\| PubMed ID: 38875608	2024
Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography. Communications biology\| PubMed ID: 38951178	2024
High-Throughput Raman Spectroscopy by Horizontally Shifted Collection Fibers. Analytical chemistry\| PubMed ID: 39038806	2024
Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning. Analytical chemistry\| PubMed ID: 39993137	2025
Cell membrane buckling governs early-stage ridge formation in butterfly wing scales. Cell reports. Physical science\| PubMed ID: 40084173	2024
Workshop on Noninvasive Glucose Monitoring 2024. Journal of diabetes science and technology\| PubMed ID: 40152467	2025
Multi-photon, label-free photoacoustic and optical imaging of NADH in brain cells. Light, science & applications\| PubMed ID: 40775235	2025