effects-moist-exposed-burn-ointment-on-wound-neovascularization

Effects of Moist Exposed Burn Ointment on Wound Neovascularization and Plasma Exosomal mir-31-5p in Diabetic Mice

Moist-exposed burn ointment (MEBO) is a traditional Chinese medicine used to treat chronic diabetic wounds; however, the underlying mechanism is unclear. ...

The Affiliated Hospital of Youjiang Medical University for Nationalities

Delayed fracture healing is a common complication of fractures that significantly impacts human health. This study aimed to explore the role of LINC00339 (lncRNA) in delayed fracture healing to provide new directions for its treatment.

Functional mechanism and clinical implications of LINC00339 in delayed fracture healing.

Osteoporosis results from decreased bone mass and disturbed bone structure. Human bone marrow mesenchymal stem cells (hBMSCs) demonstrate robust osteogenic differentiation, a critical process for bone formation. This research was designed to examine the functions of LINC01133 in osteogenic differentiation.

LINC01133 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by upregulating CTNNB1 by acting as a sponge for miR-214-3p.

Osteoporosis increases the risk of fragility fractures, impacting patients' lives. This study aimed to investigate whether LINC01271 was involved in the process of fragility fractures and healing, providing a new perspective for its diagnosis and treatment.

LINC01271 promotes fracture healing via regulating miR-19a-3p/PIK3CA axis.

Osteoporosis fracture is a common and most serious complication of osteoporosis.

Diagnostic value and fracture healing-preventing effect of upregulated microRNA-4534 in patients with osteoporotic fractures.

Glaucoma is an irreversible, progressive, degenerative eye disorder arising because of increased intraocular pressure, resulting in eventual vision loss if untreated. The QSPR relates, mathematically, by employing various algorithms, a specified property of a molecule that arises either from physical, chemical, or biological phenomena using various aspects of its structure. Here in, a similar application based on topological indices and inferences derived from the structure for the calculation of different drug properties like molar refractivity, refractive index, enthalpy, boiling points, molecular weight, and polarizability is presented. Linear regression is developed between the features of QSPR, coupled with topological indices, and performance assessment is conducted in conjunction with an Extreme Gradient Boosting model. From the obtained results, one can draw out that the XGBoost model will give better results than those from simple regression methods, specifically for polarizability. Predicted values validate the experiments. This work shows how the combination of machine learning techniques and topological indices can be used to get the best out of predictive modeling.

On QSPR analysis of glaucoma drugs using machine learning with XGBoost and regression models.

Delayed fracture healing (DFH) affects patients' quality of life, and there are limitations in diagnosis by CT scan. The purpose of the study is to evaluate the potential and mechanism of clinical application of miRNAs in DFH for early diagnosis and intervention.

Serum miR-519d-3p and BMP2: potential early diagnostic markers and their mechanism in delayed fracture healing.

Previous studies show that about 80% of lumbar disc degeneration (LDD) patients experience back or leg pain, affecting their quality of life. However, the causes of LDD are not fully understood. This study focused on exploring the expression level of miR-340-5p and SRY-related high-mobility-group box 4 (SOX4) in LDD and attempts to clarify its potential mechanism in the pathological process of LDD.

miR-340-5p alleviates the damage effect of LPS on nucleus pulposus cells by negatively regulating the expression of SOX4.

Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets. Recent multi-omics studies highlight the prognostic value of disulfidptosis-related gene (DRG) signatures in pan-cancers; however, the molecular mechanisms underlying their biological functions and therapeutic relevance remain poorly defined. Herein, a DRG score model is constructed using LASSO Cox regression across 33 cancer types, and a nomogram incorporating the DRG score is developed for prognostic prediction. The tumor microenvironment, mutation profiles, and immunotherapy responses are analyzed. The DRG score serves as an independent prognostic factor across cancers, correlating with poor outcomes and malignant features. Glucose deprivation induces disulfidptosis in SLC7A11 cells (high SLC7A11 expression), especially in cancers with a high DRG score, such as ovarian cancer. Silencing INF2 prevents disulfidptosis and decreases susceptibility to irofulven, which can be reversed by GLUT inhibitors. SLC7A11 knockdown reduces disulfidptosis, restores ATP/NADPH levels, and protects the cytoskeleton under glucose deprivation, whereas INF2 knockdown impairs cell migration. Moreover, the DRG scores predict prognosis and therapeutic responses. The SLC7A11-INF2 axis regulates disulfidptosis, migration, and drug sensitivity, highlighting its potential as a marker of metabolic vulnerability in ovarian cancer.

Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation.

Osteoporotic fractures (OPF) are one of the most common bone diseases in aging societies. MiR-3149 is a short non-coding RNA, its expression level, therapeutic effects, and mechanisms in OPF remain unclear.

Article	Year
Functional mechanism and clinical implications of LINC00339 in delayed fracture healing. Journal of orthopaedic surgery and research\| PubMed ID: 39192334	2024
LINC01133 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by upregulating CTNNB1 by acting as a sponge for miR-214-3p. Journal of orthopaedic surgery and research\| PubMed ID: 39285416	2024
LINC01271 promotes fracture healing via regulating miR-19a-3p/PIK3CA axis. Journal of orthopaedic surgery and research\| PubMed ID: 39794875	2025
Diagnostic value and fracture healing-preventing effect of upregulated microRNA-4534 in patients with osteoporotic fractures. Journal of the Formosan Medical Association = Taiwan yi zhi\| PubMed ID: 39809694	2025
On QSPR analysis of glaucoma drugs using machine learning with XGBoost and regression models. Computers in biology and medicine\| PubMed ID: 39879884	2025
Serum miR-519d-3p and BMP2: potential early diagnostic markers and their mechanism in delayed fracture healing. Journal of orthopaedic surgery and research\| PubMed ID: 40114247	2025
miR-340-5p alleviates the damage effect of LPS on nucleus pulposus cells by negatively regulating the expression of SOX4. Journal of orthopaedic surgery and research\| PubMed ID: 40691809	2025
Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40709550	2025
The diagnostic and therapeutic potential of miR-3149 in osteoporotic fractures through SMAD4. Journal of orthopaedic surgery and research\| PubMed ID: 40830796	2025

Lina Huang

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