Lixiang Xue

Institute of Medical Innovation and Research, Peking University Third Hospital

Affiliated withPeking University Third Hospital Cancer Center of Peking University Third Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Optimization of reporter gene assay: several factors influencing detection of promoter activity. Chinese medical journal\| PubMed ID: 17624263	2007
Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograft survival through nitric oxide. Journal of leukocyte biology\| PubMed ID: 24948701	2014
Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma. American journal of cancer research\| PubMed ID: 26693053	2015
Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27383182	2016
mTOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway. Journal of leukocyte biology\| PubMed ID: 27462101	2016
Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway. The Journal of investigative dermatology\| PubMed ID: 28143780	2017
A potential role of microRNAs in protein accumulation in cellular senescence analyzed by bioinformatics. PloS one\| PubMed ID: 28591170	2017
Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy. PloS one\| PubMed ID: 28783759	2017
Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage. Clinical epigenetics\| PubMed ID: 29713393	2018
Histone methylation in DNA repair and clinical practice: new findings during the past 5-years. Journal of Cancer\| PubMed ID: 29937925	2018
Myeloid-derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy. International journal of cancer\| PubMed ID: 29992569	2019
miR-29a attenuates cardiac hypertrophy through inhibition of PPARδ expression. Journal of cellular physiology\| PubMed ID: 30580435	2019
Identification of higenamine as a novel α -adrenergic receptor antagonist. Phytotherapy research : PTR\| PubMed ID: 30648306	2019
MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Gastroenterology\| PubMed ID: 30779922	2019
Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2. International immunopharmacology\| PubMed ID: 31472321	2019
Profiling and bioinformatic analysis reveal differential microRNA expression in the left and right kidneys in normal mice. FEBS letters\| PubMed ID: 31642060	2020
Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy. Aging\| PubMed ID: 32023551	2020
Metabolic factors contribute to T-cell inhibition in the ovarian cancer ascites. International journal of cancer\| PubMed ID: 32208517	2020
PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination. Theranostics\| PubMed ID: 32373215	2020
Compromise or not? A case report of successful treatment of pembrolizumab-induced hepatitis in a patient with non-small cell lung cancer with low-dose methylprednisolone and bicyclol. Thoracic cancer\| PubMed ID: 32379397	2020
Symphony of epigenetic and metabolic regulation-interaction between the histone methyltransferase EZH2 and metabolism of tumor. Clinical epigenetics\| PubMed ID: 32448308	2020
The key points in the pre-analytical procedures of blood and urine samples in metabolomics studies. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 32451742	2020
The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease. Cell research\| PubMed ID: 32457396	2020
Transcriptome analysis of common and diverged circulating miRNAs between arterial and venous during aging. Aging\| PubMed ID: 32609094	2020
Advances in Radiobiology of Stereotactic Ablative Radiotherapy. Frontiers in oncology\| PubMed ID: 32850333	2020
Gut microbes in cardiovascular diseases and their potential therapeutic applications. Protein & cell\| PubMed ID: 32989686	2021
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer. Journal for immunotherapy of cancer\| PubMed ID: 33504575	2021
Transcriptome analysis of arterial and venous circulating miRNAs during hypertension. Scientific reports\| PubMed ID: 33568719	2021
Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model. Frontiers in pharmacology\| PubMed ID: 33658924	2020
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors. Clinical epigenetics\| PubMed ID: 33761979	2021
Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1 Signaling Pathways. Stem cells international\| PubMed ID: 33763142	2021
Telmisartan attenuates human glioblastoma cells proliferation and oncogenicity by inducing the lipid oxidation. Asia-Pacific journal of clinical oncology\| PubMed ID: 33945216	2022
Senescent T cells: a potential biomarker and target for cancer therapy. EBioMedicine\| PubMed ID: 34049248	2021
CTCs detection from intraoperative salvaged blood in RCC-IVC thrombus patients by negative enrichment and iFISH identification: a preliminary study. BMC urology\| PubMed ID: 34112129	2021
Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway. Oncogene\| PubMed ID: 34155343	2021
miRNA-31 increases radiosensitivity through targeting STK40 in colorectal cancer cells. Asia-Pacific journal of clinical oncology\| PubMed ID: 34170070	2022
Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation. Frontiers in cell and developmental biology\| PubMed ID: 34249928	2021
Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy. Cancers\| PubMed ID: 34298703	2021
Mutational Analysis of PBRM1 and Significance of PBRM1 Mutation in Anti-PD-1 Immunotherapy of Clear Cell Renal Cell Carcinoma. Frontiers in oncology\| PubMed ID: 34447697	2021
Easy or Not-The Advances of EZH2 in Regulating T Cell Development, Differentiation, and Activation in Antitumor Immunity. Frontiers in immunology\| PubMed ID: 34737746	2021
Peroxisome-related genes in hepatocellular carcinoma correlated with tumor metabolism and overall survival. Clinics and research in hepatology and gastroenterology\| PubMed ID: 34798303	2022
Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics\| PubMed ID: 34815805	2021
Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor. Translational cancer research\| PubMed ID: 35116639	2021
Putative Prevention of XML Injection Against Myocardial Ischemia Is Mediated by PKC and PLA2 Proteins. Frontiers in cell and developmental biology\| PubMed ID: 35141226	2022
Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor. EBioMedicine\| PubMed ID: 35158113	2022
EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment. Frontiers in immunology\| PubMed ID: 35432300	2022
Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis. Free radical biology & medicine\| PubMed ID: 35490984	2022
The Dynamic Feature of Macrophage M1/M2 Imbalance Facilitates the Progression of Non-Traumatic Osteonecrosis of the Femoral Head. Frontiers in bioengineering and biotechnology\| PubMed ID: 35573242	2022
Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory A... Frontiers in cardiovascular medicine\| PubMed ID: 35600488	2022
A bias away from Th2 in amniotic fluid is involved in preeclampsia. Journal of reproductive immunology\| PubMed ID: 35752068	2022
Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers. iScience\| PubMed ID: 35800769	2022
Effectiveness of intraoperative cell salvage combined with a modified leucocyte depletion filter in metastatic spine tumour surgery. BMC anesthesiology\| PubMed ID: 35820820	2022
Ascitic Senescent T Cells Are Linked to Chemoresistance in Patients With Advanced High-Grade Serous Ovarian Cancer. Frontiers in oncology\| PubMed ID: 35875098	2022
Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer. Acta biochimica et biophysica Sinica\| PubMed ID: 35983975	2022
Glutamine Transporter SLC1A5 Regulates Ionizing Radiation-Derived Oxidative Damage and Ferroptosis. Oxidative medicine and cellular longevity\| PubMed ID: 36262284	2022
Combined inhibition of PARP and EZH2 for cancer treatment: Current status, opportunities, and challenges. Frontiers in pharmacology\| PubMed ID: 36263120	2022
A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a. Oncogene\| PubMed ID: 36309571	2022
Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase. Nucleic acids research\| PubMed ID: 36350608	2023
The role of immune cells in modulating chronic inflammation and osteonecrosis. Frontiers in immunology\| PubMed ID: 36582244	2022
Baseline red blood cell distribution width and perforin, dynamic levels of interleukin 6 and lactate are predictors of mortality in patients with sepsis. Journal of clinical laboratory analysis\| PubMed ID: 36631067	2023
Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis. Cellular and molecular life sciences : CMLS\| PubMed ID: 36694058	2023
The role of cholesterol metabolism in tumor therapy, from bench to bed. Frontiers in pharmacology\| PubMed ID: 37089950	2023
Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats. BMC cardiovascular disorders\| PubMed ID: 37217862	2023
Association between Changes in Plasma Metabolism and Clinical Outcomes of Sepsis. Emergency medicine international\| PubMed ID: 37346225	2023
Integrative analysis of DNA methylomes reveals novel cell-free biomarkers in lung adenocarcinoma. Frontiers in genetics\| PubMed ID: 37396036	2023
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed. Science China. Life sciences\| PubMed ID: 37450239	2023
Novel insights of EZH2-mediated epigenetic modifications in degenerative musculoskeletal diseases. Ageing research reviews\| PubMed ID: 37597667	2023
LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism. Theranostics\| PubMed ID: 38164159	2024
Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic. EBioMedicine\| PubMed ID: 38244292	2024
Systemic Characterization of the Gut Microbiota Profile after Single Mild Ischemic Stroke and Recurrent Stroke in Mice. Biomedicines\| PubMed ID: 38255299	2024
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin. Science China. Life sciences\| PubMed ID: 38300441	2024
Elevated CD4 T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19. Aging and disease\| PubMed ID: 38377029	2024
MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer. Molecular oncology\| PubMed ID: 38383842	2024
EZH2 Inhibition Enhances PD-L1 Protein Stability Through USP22-Mediated Deubiquitination in Colorectal Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 38520088	2024
Impacts of cryopreservation on phenotype and functionality of mononuclear cells in peripheral blood and ascites. Journal of translational internal medicine\| PubMed ID: 38525442	2024
Hypoxia makes EZH2 inhibitor not easy-advances of crosstalk between HIF and EZH2. Life metabolism\| PubMed ID: 38911968	2024
LPG 18:0 is a general biomarker of asthma and inhibits the differentiation and function of regulatory T-cells. The European respiratory journal\| PubMed ID: 39147414	2024
Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19. Scientific reports\| PubMed ID: 39227626	2024
Transcriptomic analysis identified novel biomarker in invasive placenta accreta spectrum. Placenta\| PubMed ID: 39549433	2024
Author Correction: Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19. Scientific reports\| PubMed ID: 39741171	2024
EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS/STING pathway via H3K27me3. Osteoarthritis and cartilage\| PubMed ID: 39938633	2025
Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia. FASEB bioAdvances\| PubMed ID: 40060945	2025
Composite score of PD-1 CD8 tumor-infiltrating lymphocytes and CD57 CD8 tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced... Chinese journal of cancer research = Chung-kuo yen cheng yen chiu\| PubMed ID: 40078557	2025
Hydrogen sulfide attenuates oxidative stress-induced cellular senescence via the Sirt3/SOD2 signaling pathway in chronic obstructive pulmonary disease. Chinese medical journal\| PubMed ID: 40082252	2025
Hydrogen sulfide attenuates PM2.5-induced COPD by inhibiting cellular senescence via the Klotho/Parkin-mediated mitophagy signaling pathway. Ecotoxicology and environmental safety\| PubMed ID: 40088608	2025
EZH2 in non-cancerous diseases: Expanding horizons. Protein & cell\| PubMed ID: 40383730	2025
Optimization of a thermochemical antibody stripping method for enhanced tyramide signal amplification-based opal multiplex immunohistochemistry in fragile tissues. BMC research notes\| PubMed ID: 40426261	2025
Lipid-Metabolism-Related Gene Signature Predicts Prognosis and Immune Microenvironment Alterations in Endometrial Cancer. Biomedicines\| PubMed ID: 40426878	2025
Nano particle loaded EZH2 inhibitors: Increased efficiency and reduced toxicity for malignant solid tumors. Journal of translational internal medicine\| PubMed ID: 40443399	2025
Role of senescent CD4 T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients. Journal of translational medicine\| PubMed ID: 40611132	2025
PEX5 deficiency enhances radiosensitivity via MGST1-GSH detoxifying function and promotes ferroptosis in liver cancer. Science China. Life sciences\| PubMed ID: 40614015	2025
Synergistic innovation in organ-on-a-chip and organoid technologies: Reshaping the future of disease modeling, drug development and precision medicine. Protein & cell\| PubMed ID: 40653861	2025
Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy. Frontiers in immunology\| PubMed ID: 40677702	2025
Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression. Journal of ovarian research\| PubMed ID: 40790593	2025
Differential regulation of FADS2 by EZH2 reveals a metabolic vulnerability in ovarian cancer treatment. EBioMedicine\| PubMed ID: 40818202	2025
Comparative effects of three SARS-CoV-2 inactivation methods on cytokine detection using LEGENDplex™ bead-based immunoassays. Journal of virological methods\| PubMed ID: 40858192	2025
Fenofibrate-mediated inhibition of tumor proliferation and progression by modulating the PTPN14/MARK/Hippo signaling axis. Pharmacological research\| PubMed ID: 40858196	2025