multilevel-microdissection-functional-structural-profiling-human

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Renal vascular dysfunction plays a critical role in the pathogenesis of multiple clinical conditions, including acute kidney injury, renal ischemia, and ...

renal-artery-function-histopathology-linked-to-plasma-fecal

Renal Artery Function and Histopathology Linked to Plasma and Fecal Metabolites in Heart Failure Patients

The gut microbiota and its associated host-microbe co-metabolites are increasingly recognized as key regulators of systemic metabolic balance and the ...

Peking University

A Gram-stain-negative, non-motile, non-spore-forming bacterium, designated T47T, was isolated from saline soil of the Suaeda corniculata rhizosphere, located on the bank of Wuliangsuhai Lake, Inner Mongolia, northern China. Strain T47T could grow at 10-40 °C (with 30 °C the optimal temperature), pH 6.0-8.0 (optimal pH 6.0) and in the presence of 0-6.0 % (w/v) NaCl [optimal 0-1.0 % (w/v)]. Phylogenetic analysis, based on 16S rRNA gene sequences, revealed that strain T47T formed a stable clade with Sphingobacterium composti 4M24T, Sphingobacterium bambusae IBFC2009T, Sphingobacterium paludis S37T and Sphingobacterium wenxiniae LQY-18T, with the 16S rRNA gene sequence similarities ranging from 91.9-95.4 %. Its major cellular fatty acids contained iso-C15 : 0 (39.9 %), summed feature 3 (iso-C15 : 0 2-OH and/or C16 : 1ω7c, 23.0 %), C16 : 0 (12.8 %) and iso-C17 : 0 3-OH (9.9 %). MK7 was the major menaquinone. The G+C content of the genomic DNA was 45.5 mol%. Based on the phenotypic, phylogenetic and genotypic characteristics, strain T47T represents a novel species within the genus Sphingobacterium, for which the name Sphingobacterium suaedae sp. nov. is proposed. The type strain is T47T ( = CGMCC 1.15277T = KCTC 42662T).

Sphingobacterium suaedae sp. nov., isolated from the rhizosphere soil of Suaeda corniculata.

A Gram-stain-positive, facultatively anaerobic bacterial strain, designated WLJ055T, with polar and subpolar flagella was isolated from the top layer of desert soil from Erdos, Inner Mongolia, northern China. Phylogenetic analysis, based on 16S rRNA gene sequences, revealed that strain WLJ055T was a member of the genus Saccharibacillus, and shared 97.17-97.24 % 16S rRNA gene sequence similarities with Saccharibacillus sacchari GR21T and Saccharibacillus kuerlensis HR1T. The major polar lipids of strain WLJ055T were diphosphatidylglycerol, phosphatidylglycerol, an unknown aminophospholipid, two unknown glycolipids and an unknown phosphoglycolipid. MK-7 was the predominant menaquinone, while anteiso-C15 : 0, C16 : 0, iso-C16 : 0, and anteiso-C17 : 0 were the major cellular fatty acids. Its genomic DNA G+C content was 55.5 mol%. DNA-DNA hybridization revealed that strain WLJ055T showed 45 ± 5 % and 40 ± 5 % genomic DNA relatedness with its two closest relatives, S. sacchari GR21T and S. kuerlensis HR1T, respectively. The results of physiological and biochemical tests allowed the discrimination of strain WLJ055T from its phylogenetic relatives. Saccharibacillus deserti sp. nov. is therefore proposed to be a novel species of the genus Saccharibacillus, with strain WLJ055T ( = CGMCC 1.15276T = KCTC 33693T) as the type strain.

Saccharibacillus deserti sp. nov., isolated from desert soil.

A Gram-stain-negative, non-motile, yellow, endophytic bacterium, designated G16-7T, was isolated from the root of Suaeda corniculata in Inner Mongolia, northern China. Phylogenetic analysis, based on the 16S rRNA gene, revealed that strain G16-7T belonged to the genus Flavobacterium, with highest sequence similarities to Flavobacterium rakeshii FCS-5T, Flavobacterium suzhouense XIN-1T, Flavobacterium beibuense F44-8T, Flavobacterium hauense BX12T and Flavobacterium shanxiense YF-2, ranging from 92.7 % to 94.9 %. The predominant fatty acids of strain G16-7T were iso-C15 : 0, summed feature 3 (consisting of C16 : 1ω7c and/or C16 : 1ω6c), iso-C17 : 0 3-OH and summed feature 9 (consisting of iso-C17 : 1ω9c and/or C16 : 0 10-methyl), while MK-6 was the major respiratory quinone. The major polar lipids were phosphatidylethanolamine, an unknown phospholipid, an unknown aminophospholipid, four unknown aminolipids and three unknown lipids. The genomic DNA G+C content of the strain was 34.2 mol%. Based on the phenotypic and genotypic characteristics, strain G16-7T is considered to represent a novel species of the genus Flavobacterium, for which the name Flavobacterium suaedae sp. nov. is proposed. The type strain is G16-7T ( = CGMCC 1.15461T = KCTC 42947T).

Flavobacterium suaedae sp. nov., an endophyte isolated from the root of Suaeda corniculata.

Graves' disease (GD) is characterized by diffuse enlargement and overactivity of the thyroid gland, which may be accompanied by other physical symptoms. Among them, depression can dramatically damage patients' quality of life, yet its prevalence in GD has not received adequate attention. Some studies have established a strong correlation between GD and increased risk of depression, though the data from current study remains limited. The summary of mechanistic insights regarding GD and depression has underpinned possible pathways by which GD contributes to depression. In this review, we first summarized the clinical evidence that supported the increased prevalence of depression by GD. We then concentrated on the mechanistic findings related to the acceleration of depression in the context of GD, as mounting evidence has indicated that GD promotes the development of depression through various mechanisms, including triggering autoimmune responses, inducing hormonal disorders, and influencing the thyroid-gut-microbiome-brain axis. Finally, we briefly presented potential therapeutic approaches to decreasing the risk of depression among patients with GD.

Graves' disease as a driver of depression: a mechanistic insight.

Extracellular vesicles (EVs) are important carriers of signaling molecules, such as nucleic acids, proteins, and lipids, and have become a focus of increasing interest due to their numerous physiological and pathological functions. For a long time, most studies on EV components focused on noncoding RNAs; however, in recent years, extracellular vesicle proteins (EVPs) have been found to play important roles in diagnosis, treatment, and drug resistance and thus have been considered favorable biomarkers and therapeutic targets for various tumors. In this review, we describe the general protocols of research on EVPs and summarize their multifaceted roles in precision medicine applications, including cancer diagnosis, dynamic monitoring of therapeutic efficacy, drug resistance research, tumor microenvironment interaction research, and anticancer drug delivery.

Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology.

To clarify the role of concentrated growth factors (CGF) in the treatment of periodontal cement defects using calcium phosphate cement (CPC) with self-curing properties.

[Therapeutic effect of concentrated growth factors combined with self-curing calcium phosphate cement on periodontal intrabony defects: Clinical and radiographic evaluation].

The COVID-19 pandemic seriously impacted people's lifestyles, leading to changes in physical activity, sleep and mental health. This study aimed to assess the recovery of these indicators in Chinese university students post-COVID-19 pandemic, and explore the association between lifestyle changes and psychological problems.

Associations of physical activity and sleep with mental health during and post-COVID-19 pandemic in chinese college students: a longitudinal cohort study.

Cutting propagation is a commonly employed technology for vegetative reproduction in agricultural, forestry, and horticultural practice. The success of cutting propagation depends on adventitious root (AR) formation-a process whereby roots regenerate from stem cuttings or leaf cuttings. In this review, we summarize the distinct stages of cutting-induced AR formation and highlight the pivotal roles of plant hormones and age in this process. Jasmonic acid (JA) acts as a master trigger for promoting AR formation, while auxin serves as the core regulator, driving AR formation. Furthermore, plant age is a crucial factor determining the regenerative competence of cuttings. Notably, age and JA collaboratively modulate auxin synthesis in cutting-induced AR formation. Overall, this review not only elucidates the molecular mechanisms underlying AR formation but also provides valuable insights for improving efficiency of cutting propagation in various plant species.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Article	Year
Sphingobacterium suaedae sp. nov., isolated from the rhizosphere soil of Suaeda corniculata. International journal of systematic and evolutionary microbiology\| PubMed ID: 26374401	2015
Saccharibacillus deserti sp. nov., isolated from desert soil. International journal of systematic and evolutionary microbiology\| PubMed ID: 26559492	2016
Flavobacterium suaedae sp. nov., an endophyte isolated from the root of Suaeda corniculata. International journal of systematic and evolutionary microbiology\| PubMed ID: 26868635	2016
Graves' disease as a driver of depression: a mechanistic insight. Frontiers in endocrinology\| PubMed ID: 37152963	2023
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 38814362	2024
[Therapeutic effect of concentrated growth factors combined with self-curing calcium phosphate cement on periodontal intrabony defects: Clinical and radiographic evaluation]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences\| PubMed ID: 39856505	2025
Associations of physical activity and sleep with mental health during and post-COVID-19 pandemic in chinese college students: a longitudinal cohort study. Comprehensive psychiatry\| PubMed ID: 40112624	2025
Adventitious Root Formation in Cuttings: Insights from and Prospects for Woody Plants. Biomolecules\| PubMed ID: 40867534	2025

Xinying Wang

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