white-brown-adipose-grafts-an-approach-to-correct-reproductive

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Transplantation of white adipose tissue (WAT) and brown adipose tissue (BAT) has emerged as a promising therapeutic strategy for reversing metabolic ...

Hospital Israelita Albert Einstein

Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems, and their prevalence rates have increased with the aging of the population. They are associated with the presence of comorbidities, in particular diabetes mellitus and hypertension, resulting in a high financial burden for the health system. Studies have indicated Klotho as a promising therapeutic approach for these conditions. Klotho reduces inflammation, oxidative stress and fibrosis and counter-regulates the renin-angiotensin-aldosterone system. In CKD and AKI, Klotho expression is downregulated from early stages and correlates with disease progression. Therefore, the restoration of its levels, through exogenous or endogenous pathways, has renoprotective effects. An important strategy for administering Klotho is through mesenchymal stem cells (MSCs). In summary, this review comprises in vitro and in vivo studies on the therapeutic potential of Klotho for the treatment of CKD and AKI through the administration of MSCs.

Klotho and Mesenchymal Stem Cells: A Review on Cell and Gene Therapy for Chronic Kidney Disease and Acute Kidney Disease.

Ensuring quality education, providing vocational training, and promoting communication technology, technical, and scientific programs are goals set by the United Nations to enhance learning opportunities for all. Critical thinking, fostered through theoretical and practical activities, is essential for building relevant skills, including literacy and numeracy. The Scientists of Tomorrow/Cientistas do Amanhã project is a reproducible initiative that can be implemented in other research centers and schools.

Article	Year
Klotho and Mesenchymal Stem Cells: A Review on Cell and Gene Therapy for Chronic Kidney Disease and Acute Kidney Disease. Pharmaceutics\| PubMed ID: 35056905	2021
Second Edition of the Scientists of Tomorrow/Cientistas do Amanhã Project: advancing scientific thinking, methodology, and equitable education. Einstein (Sao Paulo, Brazil)\| PubMed ID: 40767655	2025

Marcella Liciani Franco

Biography

JoVE Journal Publications

Other Publications