Blaine A. Pfeifer

Chemical and Biological Engineering Department, State University of New York at Buffalo

Affiliated withState University of New York at Buffalo

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2013

Other Publications

Article	Year
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry\| PubMed ID: 11955068	2002
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (Reading, England)\| PubMed ID: 12904561	2003
Precursor-Directed polyketide biosynthesis in Escherichia coli. Bioorganic & medicinal chemistry letters\| PubMed ID: 14552761	2003
Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Applied and environmental microbiology\| PubMed ID: 14602630	2003
Formulation and surface modification of poly(ester-anhydride) micro- and nanospheres. Biomaterials\| PubMed ID: 15207458	2005
Poly(ester-anhydride):poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection. International journal of pharmaceutics\| PubMed ID: 16174553	2005
Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. Applied microbiology and biotechnology\| PubMed ID: 17876579	2007
6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. Metabolic engineering\| PubMed ID: 17959404	2008
Polyketide analysis using mass spectrometry, evaporative light scattering, and charged aerosol detector systems. Analytical and bioanalytical chemistry\| PubMed ID: 18080862	2008
Bacterial hosts for natural product production. Molecular pharmaceutics\| PubMed ID: 18232637	2008
A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery. Pharmaceutical research\| PubMed ID: 18343983	2008
Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli. Biotechnology letters\| PubMed ID: 18488149	2008
A high-throughput comparison of recombinant gene expression parameters for E. coli-mediated gene transfer to P388D1 macrophage cells. Journal of biotechnology\| PubMed ID: 18694790	2008
Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. Biotechnology progress\| PubMed ID: 19634176	2009
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnology and bioengineering\| PubMed ID: 19806677	2010
Computational analysis of phenotypic space in heterologous polyketide biosynthesis--applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae. Journal of theoretical biology\| PubMed ID: 19833139	2010
Metabolic flux analysis and pharmaceutical production. Metabolic engineering\| PubMed ID: 19861167	2010
Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design. BMC systems biology\| PubMed ID: 20416071	2010
Methods and options for the heterologous production of complex natural products. Natural product reports\| PubMed ID: 21060956	2011
Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chemistry & biology\| PubMed ID: 21095573	2010
Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial biotechnology\| PubMed ID: 21261933	2009
Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and bioengineering\| PubMed ID: 21337322	2011
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. Journal of industrial microbiology & biotechnology\| PubMed ID: 21487833	2011
Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli. Applied microbiology and biotechnology\| PubMed ID: 21850432	2012
Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering. Biotechnology progress\| PubMed ID: 21905273	2012
Computational identification of gene over-expression targets for metabolic engineering of taxadiene production. Applied microbiology and biotechnology\| PubMed ID: 22124721	2012
Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds. Applied and environmental microbiology\| PubMed ID: 22287010	2012
Downstream reactions and engineering in the microbially reconstituted pathway for Taxol. Applied microbiology and biotechnology\| PubMed ID: 22460591	2012