efficacy-modified-peanut-skin-decoction-for-lung-cancer

Efficacy of Modified Peanut Skin Decoction for Lung Cancer Myelosuppression

This study conducted a randomized controlled trial to assess the efficacy and safety of modified Peanut Skin Decoction (PSD) for preventing ...

The First Affiliated Hospital of Hebei North University

Conventional chemotherapy (CC) administered to patients with non-small cell lung cancer (NSCLC) often causes adverse effects, such as cardiopulmonary dysfunction and immune system imbalance. Patients may experience anxiety and depression during the perioperative period due to various factors, such as treatment costs and cancer recurrence risks, thereby compromising the overall quality of life. Consequently, we hypothesized that integrating mindfulness-based stress reduction training (MSRT) with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.

Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with non-small cell lung cancer.

Background/Aims: Colorectal cancer (CRC) is the third most common cancer, and its progression to advanced diagnosis leads to a dismal prognosis. The long non-coding RNA (lncRNA) GUSB Pseudogene 11 (GUSBP11) can act in a variety of cancers. Nevertheless, the potential mechanism of GUSBP11 in CRC has not been reported. The purpose of this study is to investigate the relationship between the role of GUSBP11 expression in CRC progression as well as prognosis. Materials and Methods: Two hundred and fifty-nine CRC patients were recruited. Expression levels of GUSBP11 and downstream target genes in CRC cell lines were evaluated by quantitative reverse transcription polymerase chain reaction. The influence of clinical characteristics and GUSBP11 on prognosis was evaluated by the proportional hazards model. Cell-Counting-Kit-8 and transwell assays were conducted for detection of CRC cell proliferation, migration, and invasion. Dual luciferase and correlation analyses were used to validate GUSBP11 with predicted genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to analyze downstream gene function and signaling pathways. Results: The expression of GUSBP11 was upregulated in CRC and relevant to the deterioration of prognosis. The CRC cell proliferation, migration, and invasion were inhibited by GUSBP11 silencing. miR-605-3p was the downstream target gene of GUSBP11, and its expression is negatively regulated by GUSBP11. Conclusion: Taken together, this study highlights that the inhibition of miR-605-3p by GUSBP11 to regulate the downstream signaling pathway leads to prognostic malignancy and promotes tumor growth in CRC.

Article	Year
Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with non-small cell lung cancer. World journal of psychiatry\| PubMed ID: 39704353	2024
Prognostic Value of Long Non-Coding RNAs GUSB Pseudogene 11 in Colorectal Cancer and Its Regulatory Effect on Tumor Progression. Turkish archives of pediatrics\| PubMed ID: 40420632	2025

Zhan-Lin Li

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