Shing-Hwa Liu

Institute of Toxicology, National Taiwan University

Affiliated withNational Taiwan University China Medical University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Inhibition of inducible nitric oxide synthase by beta-lapachone in rat alveolar macrophages and aorta. British journal of pharmacology\| PubMed ID: 10188987	1999
Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. PloS one\| PubMed ID: 17971859	2007
Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PloS one\| PubMed ID: 18197261	2008
Uropathogenic Escherichia coli-induced inflammation alters mouse urinary bladder contraction via an interleukin-6-activated inducible nitric oxide synthase-related pathway. Infection and immunity\| PubMed ID: 19470750	2009
IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cellular and molecular life sciences : CMLS\| PubMed ID: 20221786	2010
Arsenic inhibits myogenic differentiation and muscle regeneration. Environmental health perspectives\| PubMed ID: 20299303	2010
Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro. British journal of pharmacology\| PubMed ID: 21265825	2011
Nanoparticles prepared from the water extract of Gusuibu (Drynaria fortunei J. Sm.) protects osteoblasts against insults and promotes cell maturation. International journal of nanomedicine\| PubMed ID: 21796243	2011
Endoplasmic reticulum stress implicated in the development of renal fibrosis. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21863214	2011
Mite allergen Der-p2 triggers human B lymphocyte activation and Toll-like receptor-4 induction. PloS one\| PubMed ID: 21909400	2011
Arsenic and diabetes: current perspectives. The Kaohsiung journal of medical sciences\| PubMed ID: 21914528	2011
Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PloS one\| PubMed ID: 22438966	2012
C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PloS one\| PubMed ID: 22815824	2012
Exposure to low dose of cinnabar (a naturally occurring mercuric sulfide (HgS)) caused neurotoxicological effects in offspring mice. Journal of biomedicine & biotechnology\| PubMed ID: 22888198	2012
Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PloS one\| PubMed ID: 22937084	2012
Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophospha... Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22961095	2013
Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes\| PubMed ID: 23069626	2013
Involvement of caspase-12-dependent apoptotic pathway in ionic radiocontrast urografin-induced renal tubular cell injury. Toxicology and applied pharmacology\| PubMed ID: 23116894	2013
Mercuric compounds induce pancreatic islets dysfunction and apoptosis in vivo. International journal of molecular sciences\| PubMed ID: 23202902	2012
Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PloS one\| PubMed ID: 23405080	2013
EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 23483610	2013
Low molecular weight chitosan accelerates glucagon-like peptide-1 secretion in human intestinal endocrine cells via a p38-dependent pathway. Journal of agricultural and food chemistry\| PubMed ID: 23611362	2013
Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor f... PloS one\| PubMed ID: 23776688	2013
Genistein induces oestrogen receptor-α gene expression in osteoblasts through the activation of mitogen-activated protein kinases/NF-κB/activator protein-1 and promotes cell mineralisation. The British journal of nutrition\| PubMed ID: 23829885	2014
Hemorrhagic cystitis in children treated with alkylating agent cyclophosphamide: The experience of a medical center in Taiwan. Journal of the Formosan Medical Association = Taiwan yi zhi\| PubMed ID: 23880225	2015
Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro. Toxicology\| PubMed ID: 23939141	2013
C/EBP homologous protein deficiency aggravates acute pancreatitis and associated lung injury. World journal of gastroenterology\| PubMed ID: 24222953	2013
Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury. PloS one\| PubMed ID: 24223196	2013
Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells. PloS one\| PubMed ID: 24349176	2013
Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 24375705	2014
Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 24431215	2014
Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats. Environmental health perspectives\| PubMed ID: 24531206	2014
Osteoporosis Prevention by Adlay ( Yì Yǐ: The Seeds of Coix Lachryma-Jobi L. var. ma-yuen Stapf) in a Mouse Model. Journal of traditional and complementary medicine\| PubMed ID: 24716168	2013
Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo. Oncotarget\| PubMed ID: 24947902	2014
Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK/NF-κB signaling pathway. The American journal of Chinese medicine\| PubMed ID: 25004880	2014
Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Free radical biology & medicine\| PubMed ID: 25014566	2014
Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway. The Journal of nutritional biochemistry\| PubMed ID: 25087994	2014
CCAAT-Enhancer-Binding Protein Homologous Protein Deficiency Attenuates Oxidative Stress and Renal Ischemia-Reperfusion Injury. Antioxidants & redox signaling\| PubMed ID: 25178318	2015
The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination. Oncotarget\| PubMed ID: 25226618	2014
Titanium nanoparticle inhalation induces renal fibrosis in mice via an oxidative stress upregulated transforming growth factor-β pathway. Chemical research in toxicology\| PubMed ID: 25406100	2015
PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 25410618	2015
Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification. Journal of ethnopharmacology\| PubMed ID: 25456426	2014
Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 25481278	2015
Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition. Molecular oncology\| PubMed ID: 25619450	2015
Cancer risk in HBV patients with statin and metformin use: a population-based cohort study. Medicine\| PubMed ID: 25674734	2015
Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation. Archives of toxicology\| PubMed ID: 25726415	2016
Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via adenosine monophosphate (AMP)-activated protein kinase activation and inhibition of lipogenesis-associat... Journal of agricultural and food chemistry\| PubMed ID: 25756465	2015
Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Estrogen-Deficient Female Mice. Environmental health perspectives\| PubMed ID: 25859628	2015
Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model. Scientific reports\| PubMed ID: 25873429	2015
Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. PloS one\| PubMed ID: 25898207	2015
Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway. PloS one\| PubMed ID: 26359868	2015
Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Antioxidants & redox signaling\| PubMed ID: 26415004	2016
Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo. Oncotarget\| PubMed ID: 26447758	2015
ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. Scientific reports\| PubMed ID: 26449648	2015
Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway. International journal of nanomedicine\| PubMed ID: 26451104	2015
Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 26497299	2016
Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation. Oncotarget\| PubMed ID: 26517350	2015
Dementia Risk in Irradiated Patients With Head and Neck Cancer. Medicine\| PubMed ID: 26559280	2015
Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. The Journal of pathology\| PubMed ID: 26586640	2016
MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma. Scientific reports\| PubMed ID: 26592553	2015
Long-Term Feeding of Chitosan Ameliorates Glucose and Lipid Metabolism in a High-Fructose-Diet-Impaired Rat Model of Glucose Tolerance. Marine drugs\| PubMed ID: 26690452	2015
MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study. American journal of cancer research\| PubMed ID: 26807316	2015
Epigallocatechin Gallate Attenuates Partial Bladder Outlet Obstruction-induced Bladder Injury via Suppression of Endoplasmic Reticulum Stress-related Apoptosis-In Vivo Study. Urology\| PubMed ID: 26820120	2016
Outcomes of Induction Chemotherapy for Head and Neck Cancer Patients: A Combined Study of Two National Cohorts in Taiwan. Medicine\| PubMed ID: 26886647	2016
C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget\| PubMed ID: 26942460	2016
Influenza Vaccination Reduces Dementia Risk in Chronic Kidney Disease Patients: A Population-Based Cohort Study. Medicine\| PubMed ID: 26945371	2016
Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro. Oncotarget\| PubMed ID: 26959118	2016
The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction. Oncotarget\| PubMed ID: 27056903	2016
Curative-Intent Aggressive Treatment Improves Survival in Elderly Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma and High Comorbidity Index. Medicine\| PubMed ID: 27057882	2016
Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 27064011	2016
Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells. Journal of agricultural and food chemistry\| PubMed ID: 27144449	2016
Ultrasound Enhances the Expression of Brain-Derived Neurotrophic Factor in Astrocyte Through Activation of TrkB-Akt and Calcium-CaMK Signaling Pathways. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 27252349	2017
MicroRNA-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing. Oncotarget\| PubMed ID: 27285985	2016
Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 27473919	2016
Statins improve outcomes of nonsurgical curative treatments in hepatocellular carcinoma patients. Medicine\| PubMed ID: 27603355	2016
Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury. Scientific reports\| PubMed ID: 27665710	2016
Statins Dose-Dependently Exert Significant Chemopreventive Effects Against Various Cancers in Chronic Obstructive Pulmonary Disease Patients: A Population-Based Cohort Study. Journal of Cancer\| PubMed ID: 27698930	2016
Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways. PloS one\| PubMed ID: 27930712	2016
Transplantation of human skeletal muscle-derived progenitor cells ameliorates knee osteoarthritis in streptozotocin-induced diabetic mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 27935109	2017
Effects of Bisphenol A Metabolite 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene on Lung Function and Type 2 Pulmonary Alveolar Epithelial Cell Growth. Scientific reports\| PubMed ID: 27982077	2016
Protection of Dexmedetomidine Against Ischemia/Reperfusion-Induced Apoptotic Insults to Neuronal Cells Occurs Via an Intrinsic Mitochondria-Dependent Pathway. Journal of cellular biochemistry\| PubMed ID: 27987330	2017
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. Journal of Cancer\| PubMed ID: 27994679	2016
Tributyltin exposure at noncytotoxic doses dysregulates pancreatic β-cell function in vitro and in vivo. Archives of toxicology\| PubMed ID: 28180948	2017
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway. International journal of oncology\| PubMed ID: 28197638	2017
Benzo[a]pyrene activates interleukin-6 induction and suppresses nitric oxide-induced apoptosis in rat vascular smooth muscle cells. PloS one\| PubMed ID: 28531207	2017
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity. Scientific reports\| PubMed ID: 28600541	2017
TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Circulation research\| PubMed ID: 28724746	2017
Potential Association of IL1B Polymorphism With Iron Deficiency Risk in Childhood Helicobacter pylori Infection. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 28727656	2018
Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats. Marine drugs\| PubMed ID: 28737708	2017
Plasticizer di(2-ethylhexyl)phthalate interferes with osteoblastogenesis and adipogenesis in a mouse model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 28921615	2018
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1. Scientific reports\| PubMed ID: 28931916	2017
The regulatory effects of fish oil and chitosan on hepatic lipogenic signals in high-fat diet-induced obese rats. Journal of food and drug analysis\| PubMed ID: 28987369	2017
Genotoxicity and 28-day oral toxicity studies of a functional food mixture containing maltodextrin, white kidney bean extract, mulberry leaf extract, and niacin-bound chromium complex. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 29155076	2018
Comparison of outcome and cost among open, laparoscopic, and robotic surgical treatments for rectal cancer: A propensity score matched analysis of nationwide inpatient sample data. Journal of surgical oncology\| PubMed ID: 29284067	2018
Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 29512306	2018
Hepcidin correlates with interleukin-1β and interleukin-6 but not iron deficiency in children with Helicobacter pylori infection. Pediatrics and neonatology\| PubMed ID: 29548703	2018
Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells. BMC cancer\| PubMed ID: 29614990	2018
Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction. Scientific reports\| PubMed ID: 29615782	2018
Fish Oil Supplementation Alleviates the Altered Lipid Homeostasis in Blood, Liver, and Adipose Tissues in High-Fat Diet-Fed Rats. Journal of agricultural and food chemistry\| PubMed ID: 29627983	2018
Low-dose tributyltin exposure induces an oxidative stress-triggered JNK-related pancreatic β-cell apoptosis and a reversible hypoinsulinemic hyperglycemia in mice. Scientific reports\| PubMed ID: 29636531	2018
Plasticizer Di-(2-Ethylhexyl)Phthalate Induces Epithelial-to-Mesenchymal Transition and Renal Fibrosis In Vitro and In Vivo. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 29669060	2018
Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo. Journal of translational medicine\| PubMed ID: 29921305	2018
Effects of tebuconazole on cytochrome P450 enzymes, oxidative stress, and endocrine disruption in male rats. Environmental toxicology\| PubMed ID: 29923317	2018
Islet-like clusters derived from skeletal muscle-derived stem/progenitor cells for autologous transplantation to control type 1 diabetes in mice. Artificial cells, nanomedicine, and biotechnology\| PubMed ID: 30032651	2018
Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats. Marine drugs\| PubMed ID: 30060615	2018
Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 30217261	2018
Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 30288546	2018
Adverse effects of acrolein, a ubiquitous environmental toxicant, on muscle regeneration and mass. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30378754	2019
Prenatal developmental toxicity study of strontium citrate in Sprague Dawley rats. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 30529436	2019
MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis. International journal of molecular sciences\| PubMed ID: 30586948	2018
Exposure of Macrophages to Low-Dose Gadolinium-Based Contrast Medium: Impact on Oxidative Stress and Cytokines Production. Contrast media & molecular imaging\| PubMed ID: 30627059	2018
Resistant Maltodextrin Ameliorates Altered Hepatic Lipid Homeostasis via Activation of AMP-Activated Protein Kinase in a High-Fat Diet-Fed Rat Model. Nutrients\| PubMed ID: 30699992	2019
Correction to: Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 30741319	2019
Gender difference of CCAAT/enhancer binding protein homologous protein deficiency in susceptibility to osteopenia. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 30835896	2019
The antifibrotic and anti-inflammatory effects of icariin on the kidney in a unilateral ureteral obstruction mouse model. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 30978648	2019
Honokiol Induces Autophagic Apoptosis in Neuroblastoma Cells through a P53-Dependent Pathway. The American journal of Chinese medicine\| PubMed ID: 31091975	2019
Corrigendum to "Prenatal developmental toxicity study of strontium citrate in Sprague Dawley rats" [Regul. Toxicol. Pharmacol. 101 (2019), 196-200]. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 31153644	2019
Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK/PGC-1α Signaling and Prevents Obesity-Related Skeletal Muscle Wasting. Marine drugs\| PubMed ID: 31242648	2019
Trifluoperazine, an Antipsychotic Drug, Effectively Reduces Drug Resistance in Cisplatin-Resistant Urothelial Carcinoma Cells via Suppressing Bcl-xL: An In Vitro and In Vivo Study. International journal of molecular sciences\| PubMed ID: 31262032	2019
Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury. Cells\| PubMed ID: 31262060	2019
Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo. Vascular pharmacology\| PubMed ID: 31279923	2019
Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 31325534	2019
Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis. Toxicology\| PubMed ID: 31330229	2019
Cadmium exposure induces pancreatic β-cell death via a Ca-triggered JNK/CHOP-related apoptotic signaling pathway. Toxicology\| PubMed ID: 31348969	2019
Biomechanical and tomographic differences in the microarchitecture and strength of trabecular and cortical bone in the early stage of male osteoporosis. PloS one\| PubMed ID: 31393911	2019
The Anti-Obesity Effect of Polysaccharide-Rich Red Algae () Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters. Marine drugs\| PubMed ID: 31540318	2019
The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study. Cells\| PubMed ID: 31627336	2019
Low Intensity Pulsed Ultrasound Prevents Recurrent Ischemic Stroke in a Cerebral Ischemia/Reperfusion Injury Mouse Model via Brain-derived Neurotrophic Factor Induction. International journal of molecular sciences\| PubMed ID: 31635269	2019
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. Archives of toxicology\| PubMed ID: 31734849	2020
Suppression of Angiogenesis by Targeting Cyclin-Dependent Kinase 7 in Human Umbilical Vein Endothelial Cells and Renal Cell Carcinoma: An In Vitro and In Vivo Study. Cells\| PubMed ID: 31752390	2019
The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma. Cancer letters\| PubMed ID: 31812697	2020
Comparative Effects and Mechanisms of Chitosan and Its Derivatives on Hypercholesterolemia in High-Fat Diet-Fed Rats. International journal of molecular sciences\| PubMed ID: 31877743	2019
Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model. EJNMMI research\| PubMed ID: 32096011	2020
Exposure of low-concentration arsenic induces myotube atrophy by inhibiting an Akt signaling pathway. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 32184170	2020
Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers: and study. American journal of cancer research\| PubMed ID: 32266102	2020
Safety evaluation of water extract of Gastrodia elata Blume: Genotoxicity and 28-day oral toxicity studies. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 32278877	2020
Cerebral Blood Flow-Guided Manipulation of Arterial Blood Pressure Attenuates Hippocampal Apoptosis After Asphyxia-Induced Cardiac Arrest in Rats. Journal of the American Heart Association\| PubMed ID: 32552439	2020
Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice. Molecules (Basel, Switzerland)\| PubMed ID: 32635466	2020
Effects of Chitosan Oligosaccharide on Plasma and Hepatic Lipid Metabolism and Liver Histomorphology in Normal Sprague-Dawley Rats. Marine drugs\| PubMed ID: 32748864	2020
Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis. Scientific reports\| PubMed ID: 32868865	2020
Genistein Improves Bone Healing via Triggering Estrogen Receptor Alpha-Mediated Expressions of Osteogenesis-Associated Genes and Consequent Maturation of Osteoblasts. Journal of agricultural and food chemistry\| PubMed ID: 32897066	2020
Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 33007732	2020
Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 33176446	2021
Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation. Molecules (Basel, Switzerland)\| PubMed ID: 33396516	2020
Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-In... International journal of molecular sciences\| PubMed ID: 33498889	2021
THZ1, a covalent CDK7 inhibitor, enhances gemcitabine-induced cytotoxicity via suppression of Bcl-2 in urothelial carcinoma. American journal of cancer research\| PubMed ID: 33520367	2021
The role of a point-of-care ultrasound protocol in facilitating clinical decisions for snakebite envenomation in Taiwan: a pilot study. Clinical toxicology (Philadelphia, Pa.)\| PubMed ID: 33605805	2021
CDK7 inhibition by THZ1 suppresses cancer stemness in both chemonaïve and chemoresistant urothelial carcinoma via the hedgehog signaling pathway. Cancer letters\| PubMed ID: 33741425	2021
Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active m... Toxicology\| PubMed ID: 33771661	2021
Genistein Triggers Translocation of Estrogen Receptor-Alpha in Mitochondria to Induce Expressions of ATP Synthesis-Associated Genes and Improves Energy Production and Osteoblast Maturation. The American journal of Chinese medicine\| PubMed ID: 33853499	2021
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Medi... International journal of molecular sciences\| PubMed ID: 33922211	2021
Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death. Neurotoxicology\| PubMed ID: 34038756	2021
Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway. Oxidative medicine and cellular longevity\| PubMed ID: 34136065	2021
Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice. Chemico-biological interactions\| PubMed ID: 34153226	2021
Chitosan Oligosaccharide Alleviates Abnormal Glucose Metabolism without Inhibition of Hepatic Lipid Accumulation in a High-Fat Diet/Streptozotocin-Induced Diabetic Rat Model. Marine drugs\| PubMed ID: 34201848	2021
Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells. International journal of molecular sciences\| PubMed ID: 34281282	2021
Influence of Dietary Chitosan Feeding Duration on Glucose and Lipid Metabolism in a Diabetic Rat Model. Molecules (Basel, Switzerland)\| PubMed ID: 34443619	2021
A novel indium-labeled dual carbonic anhydrase 9-targeted probe as a potential SPECT imaging radiotracer for detection of hypoxic colorectal cancer cells. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 34450241	2021
Analysis of the Necrosis-Inducing Components of the Venom of and Assessment of the Neutralization Ability of Freeze-Dried Antivenom. Toxins\| PubMed ID: 34564623	2021
Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression. Journal of agricultural and food chemistry\| PubMed ID: 34723490	2021
PR-619, a General Inhibitor of Deubiquitylating Enzymes, Diminishes Cisplatin Resistance in Urothelial Carcinoma Cells through the Suppression of c-Myc: An In Vitro and In Vivo Study. International journal of molecular sciences\| PubMed ID: 34769137	2021
Early elimination of uremic toxin ameliorates AKI-to-CKD transition. Clinical science (London, England : 1979)\| PubMed ID: 34796904	2021
Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model. Biomedicines\| PubMed ID: 34829948	2021
Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model. Nutrients\| PubMed ID: 34836176	2021
CARMA3 Promotes Colorectal Cancer Cell Motility and Cancer Stemness via YAP-Mediated NF-κB Activation. Cancers\| PubMed ID: 34885061	2021
Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. Cell biology and toxicology\| PubMed ID: 34973135	2022
Quercetin induces tongue squamous cell carcinoma cell apoptosis via the JNK activation-regulated ERK/GSK-3α/β-mediated mitochondria-dependent apoptotic signaling pathway. Oncology letters\| PubMed ID: 35111247	2022
Polysaccharide-Rich Red Algae () Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic R... Molecules (Basel, Switzerland)\| PubMed ID: 35209236	2022
Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway. International journal of molecular sciences\| PubMed ID: 35270009	2022
Therapeutic effect of quercetin polymeric nanoparticles on ischemia/reperfusion-induced acute kidney injury in mice. Biochemical and biophysical research communications\| PubMed ID: 35397424	2022
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer. Clinical science (London, England : 1979)\| PubMed ID: 35475476	2022
Norketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells via a Ca-Regulated ERK1/2-Activating Pathway. International journal of molecular sciences\| PubMed ID: 35563057	2022
Fish Oil Enriched n-3 Polyunsaturated Fatty Acids Improve Ketogenic Low-Carbohydrate/High-Fat Diet-Caused Dyslipidemia, Excessive Fat Accumulation, and Weight Control in Rats. Nutrients\| PubMed ID: 35565762	2022
Polysaccharide-rich red algae (Gelidium amansii) hot-water extracts ameliorate the altered plasma cholesterol and hepatic lipid homeostasis in high-fat diet-fed rats. Journal of food and drug analysis\| PubMed ID: 35696225	2021
The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition. Journal of biomedical science\| PubMed ID: 35765067	2022
Improvement of Glycemic Control by a Functional Food Mixture Containing Maltodextrin, White Kidney Bean Extract, Mulberry Leaf Extract, and Niacin-Bound Chromium Complex in Obese Diabetic M... Metabolites\| PubMed ID: 35893259	2022
Contribution of the Testosterone Androgen Receptor-PARD3B Signaling Axis to Tumorigenesis and Malignance of Glioblastoma Multiforme through Stimulating Cell Proliferation and Colony Formatio... Journal of clinical medicine\| PubMed ID: 36013056	2022
The UCHL5 inhibitor b-AP15 overcomes cisplatin resistance via suppression of cancer stemness in urothelial carcinoma. Molecular therapy oncolytics\| PubMed ID: 36090476	2022
Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules (Basel, Switzerland)\| PubMed ID: 36144517	2022
Aryl hydrocarbon receptor deficiency augments dysregulated microangiogenesis and diabetic retinopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 36152407	2022
Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 36252918	2023
Inhaled Carbon Dioxide Improves Neurological Outcomes by Downregulating Hippocampal Autophagy and Apoptosis in an Asphyxia-Induced Cardiac Arrest and Resuscitation Rat Model. Journal of the American Heart Association\| PubMed ID: 36314493	2022
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging. Archives of toxicology\| PubMed ID: 36319700	2023
Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice. Journal of traditional and complementary medicine\| PubMed ID: 36325240	2022
Therapeutic Ultrasound Halts Progression of Chronic Kidney Disease In Vivo via the Regulation of Markers Associated with Renal Epithelial-Mesenchymal Transition and Senescence. International journal of molecular sciences\| PubMed ID: 36362179	2022
A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 36382567	2023
Involvement of AMPKα and MAPK-ERK/-JNK Signals in Docetaxel-Induced Human Tongue Squamous Cell Carcinoma Cell Apoptosis. International journal of molecular sciences\| PubMed ID: 36430348	2022
genotoxicity assessment and 28-day repeated dose oral toxicity study of steady-calcium formula in rats. Toxicology reports\| PubMed ID: 36518413	2022
Antidiabetic Properties of Chitosan and Its Derivatives. Marine drugs\| PubMed ID: 36547931	2022
Therapeutic ultrasound treatment for the prevention of chronic kidney disease-associated muscle wasting in mice. Artificial cells, nanomedicine, and biotechnology\| PubMed ID: 37195194	2023
Resveratrol Alleviates Advanced Glycation End-Products-Related Renal Dysfunction in D-Galactose-Induced Aging Mice. Metabolites\| PubMed ID: 37233696	2023
Application of Sonographic Assessments of the Rate of Proximal Progression to Monitor Bite-Related Local Envenomation: A Prospective Observational Study. Tropical medicine and infectious disease\| PubMed ID: 37235294	2023
Neuroprotection by Abdominal Ultrasound in Lipopolysaccharide-Induced Systemic Inflammation. International journal of molecular sciences\| PubMed ID: 37298275	2023
Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness. Archives of toxicology\| PubMed ID: 37314482	2023
Resveratrol triggers the ER stress-mediated intrinsic apoptosis of neuroblastoma cells coupled with suppression of Rho-dependent migration and consequently prolongs mouse survival. Chemico-biological interactions\| PubMed ID: 37482209	2023
Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis. American journal of cancer research\| PubMed ID: 37559983	2023
Inhibition of Indoxyl Sulfate-Induced Reactive Oxygen Species-Related Ferroptosis Alleviates Renal Cell Injury In Vitro and Chronic Kidney Disease Progression In Vivo. Antioxidants (Basel, Switzerland)\| PubMed ID: 38001784	2023
Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery. iScience\| PubMed ID: 38187189	2023
Nε-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma. International journal of biological sciences\| PubMed ID: 38250151	2024
The Ratio of Plasma Amyloid-β 1-42 over Serum Albumin Can Be a Novel Biomarker Signature for Diagnosing End-Stage Renal Disease-Associated Cognitive Impairment. Journal of Alzheimer's disease : JAD\| PubMed ID: 38250771	2024
Roles of oxidative stress/JNK/ERK signals in paraquat-triggered hepatic apoptosis. Current research in toxicology\| PubMed ID: 38379848	2024
Dehulled Adlay (Coix lachryma-jobi L.) ameliorates hepatic gluconeogenesis and steatosis in streptozotocin/high-fat diet-induced diabetic rats. Journal of food and drug analysis\| PubMed ID: 38526822	2023
Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 38530514	2024
Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology\| PubMed ID: 38815787	2024
Exendin-4, a glucagon-like peptide-1 receptor agonist, alleviates muscular dysfunction and wasting in a streptozotocin-induced diabetic mouse model compared to metformin. Tissue & cell\| PubMed ID: 39018713	2024
A negative regulatory role of β-cell-derived exosomes in the glucose-stimulated insulin secretion of recipient β-cells. Archives of toxicology\| PubMed ID: 39127846	2024
Role of advanced glycation end-products in age-associated kidney dysfunction in naturally aging mice. Life sciences\| PubMed ID: 39151883	2024
Imperatorin ameliorates ferroptotic cell death, inflammation, and renal fibrosis in a unilateral ureteral obstruction mouse model. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 39341130	2024
The therapeutic effect and underlying biochemical mechanism of methylprednisolone and D-methionine in "rescuing" noise-induced hearing loss in guinea pigs. Hearing research\| PubMed ID: 39550992	2024
Tetrabromobisphenol A induced p38-MAPK/AMPKα activation downstream-triggered CHOP signal contributing to neuronal apoptosis and death. Toxicology\| PubMed ID: 39586487	2025
Attenuation of diabetes-mediated muscle atrophy in rats by fish oil enriched omega-3 polyunsaturated fatty acids supplementation. Journal of food and drug analysis\| PubMed ID: 39666277	2023
Synergistic Effects of Chitosan and Fish Oil on Lipid Metabolism in Rats Fed a High-Fat and Low-Carbohydrate Diet. Nutrients\| PubMed ID: 39683472	2024
Camptothecin Triggers Apoptosis in Human and Mouse Drug-resistant Glioblastoma Cells ROS-mediated Activation of the p53-p21-CD1/CDK2-E2F1-Bcl-xL Signaling Axis. Anticancer research\| PubMed ID: 39890198	2025
The herbicide 2,4-dichlorophenoxyacetic acid induces pancreatic β-cell death via oxidative stress-activated AMPKα signal downstream-regulated apoptotic pathway. Toxicology letters\| PubMed ID: 39921193	2025
Chronic Kidney Disease and Osteoarthritis: Current Understanding and Future Research Directions. International journal of molecular sciences\| PubMed ID: 40004032	2025
Chlorpyrifos-oxon results in autophagic flux dysfunction contributing to neuronal apoptosis via a ROS/AMPK/CHOP activation pathway. Chemico-biological interactions\| PubMed ID: 40049439	2025
Antimony induces mitochondria-dependent and ER stress-triggered apoptosis via the oxidative stress-activated JNK signaling pathway in pancreatic islet β-cells. Toxicology\| PubMed ID: 40368022	2025
Zinc protoporphyrin accumulation as a positive regulator of renal heme oxygenase-1 participates in the progression of chronic kidney disease. Biochemical and biophysical research communications\| PubMed ID: 40381240	2025
Uremic toxin indoxyl sulfate induces the imbalance of cellular iron metabolism and oxidative stress to interfere with myogenesis in myoblasts. Chemico-biological interactions\| PubMed ID: 40449865	2025