impact-subcutaneous-mastectomy-under-laparoscopy-with-situ-prosthetic

Impact of Subcutaneous Mastectomy under Laparoscopy with <em>In Situ</em> Prosthetic Reconstruction on Aesthetic Appearance in Breast Cancer Patients

Breast cancer remains one of the most widespread malignant tumors affecting women, with a range of treatment options available, among which surgical ...

machine-learning-based-identification-tamoxifen-resistance-associated

Machine Learning-Based Identification of Tamoxifen Resistance-Associated Genes and Their Application in Prognostic Modeling of Breast Cancer

Tamoxifen is a key endocrine therapy for estrogen receptor-positive (ER+) breast cancer, but acquired resistance limits long-term efficacy. The molecular ...

Wuzhong People's Hospital

Wuzhong People's Hospital of Suzhou City

Lipid metabolism is closely related to the occurrence and development of breast cancer. Our purpose was to establish a novel model based on lipid metabolism-related long noncoding RNAs (lncRNAs) and evaluate the potential clinical value in predicting prognosis for patients suffering from breast cancer.

A novel prognostic model associated with the overall survival in patients with breast cancer based on lipid metabolism-related long noncoding RNAs.

Breast cancer (BC) is a lethal disorder that threatens the life safety of the majority of females globally, with rising morbidity and mortality year by year. Doxorubicin is a cytotoxic anthracycline antibiotic that is widely used as one of the first-line chemotherapy agents for patients with BC. However, the efficacy of doxorubicin in the clinic is largely limited by its serious side effects and acquired drug resistance. Allicin (diallyl thiosulfinate), as the major component and key active compound present in freshly crushed garlic, has shown potential effects in suppressing chemotherapy resistance in various cancers. Our research aimed to explore the relationship between allicin and doxorubicin resistance in BC. To generate doxorubicin-resistant BC cell lines (MCF-7/DOX and MDA-MB-231/DOX), doxorubicin-sensitive parental cell lines MCF-7 and MDA-MB-231 were continuously exposed to stepwise increased concentrations of doxorubicin over a period of 6 months. CCK-8, colony formation, flow cytometry, RT-qPCR, and western blotting assays were performed to investigate the effects of allicin and/or doxorubicin treatment on the viability, proliferation and apoptosis and the expression of Nrf2, HO-1, phosphate AKT and AKT in doxorubicin-resistant BC cells. Our results showed that combined treatment of allicin with doxorubicin exhibited better effects on inhibiting the proliferation and enhancing the apoptosis of doxorubicin-resistant BC cells than treatment with allicin or doxorubicin alone. Mechanistically, allicin suppressed the levels of Nrf2, HO-1, and phosphate AKT in doxorubicin-resistant BC cells. Collectively, allicin improves the doxorubicin sensitivity of BC cells by inactivating the Nrf2/HO-1 signaling pathway.

Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway.

Several malignant tumors have been shown to overexpress aldolase A (ALDOA), a crucial enzyme in the glycolytic cycle. Though, it is still unknown how ALDOA contributes to breast cancer (BC).

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Article	Year
A novel prognostic model associated with the overall survival in patients with breast cancer based on lipid metabolism-related long noncoding RNAs. Journal of clinical laboratory analysis\| PubMed ID: 35441740	2022
Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway. Cell biochemistry and biophysics\| PubMed ID: 38411783	2024
The Expression and Clinical Significance of ALDOA in Breast Cancer. OncoTargets and therapy\| PubMed ID: 40786664	2025

Guojian Shi

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