Yuri N. Utkin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Affiliated withRussian Academy of Sciences

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs. Frontiers in pharmacology\| PubMed ID: 31333465	2019
First tryptophan-containing weak neurotoxin from cobra venom. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 11223079	2001
Toxicity of cobra venom components to cockroach Gromphadorhina portentosa. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 12368123	2002
A comparative study on selectivity of alpha-conotoxins GI and ImI using their synthetic analogues and derivatives. Neurochemical research\| PubMed ID: 12675150	2003
Interaction of the P-type cardiotoxin with phospholipid membranes. European journal of biochemistry\| PubMed ID: 12709064	2003
The first representative of glycosylated three-fingered toxins. Cytotoxin from the Naja kaouthia cobra venom. European journal of biochemistry\| PubMed ID: 15128311	2004
Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins. The Biochemical journal\| PubMed ID: 15584897	2005
Cobra venom contains a pool of cysteine-rich secretory proteins. Biochemical and biophysical research communications\| PubMed ID: 15670767	2005
Isolation and preliminary crystallographic studies of two new phospholipases A2 from Vipera nikolskii venom. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16510990	2005
alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor. The FEBS journal\| PubMed ID: 16689926	2006
Alpha-conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors. The FEBS journal\| PubMed ID: 16956365	2006
Alpha-conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins. Journal of molecular neuroscience : MN\| PubMed ID: 17192636	2006
Behavioural effects in mice and intoxication symptomatology of weak neurotoxin from cobra Naja kaouthia. Basic & clinical pharmacology & toxicology\| PubMed ID: 17371532	2007
Heterodimeric neurotoxic phospholipases A2--the first proteins from venom of recently established species Vipera nikolskii: implication of venom composition in viper systematics. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 18083205	2008
Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification. The Journal of biological chemistry\| PubMed ID: 18381281	2008
Cysteine-rich venom proteins from the snakes of Viperinae subfamily - molecular cloning and phylogenetic relationship. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 19041663	2009
Naturally occurring and synthetic peptides acting on nicotinic acetylcholine receptors. Current pharmaceutical design\| PubMed ID: 19601841	2009
A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 19622365	2010
An unusual phospholipase A₂ from puff adder Bitis arietans venom--a novel blocker of nicotinic acetylcholine receptors. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 21333664	2011
Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids. PloS one\| PubMed ID: 21559494	2011
Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors. The Journal of biological chemistry\| PubMed ID: 22223648	2012
Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. The Journal of biological chemistry\| PubMed ID: 22613724	2012
Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice. Journal of venom research\| PubMed ID: 23577231	2013
Vietnamese Heterometrus laoticus scorpion venom: evidence for analgesic and anti-inflammatory activity and isolation of new polypeptide toxin acting on Kv1.3 potassium channel. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 24189292	2014
Nerve growth factor from cobra venom inhibits the growth of Ehrlich tumor in mice. Toxins\| PubMed ID: 24577582	2014
Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms. Biochimica et biophysica acta\| PubMed ID: 25450350	2015
Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2. PloS one\| PubMed ID: 25522251	2014
Antiproliferative activity of cobra venom cytotoxins. Current topics in medicinal chemistry\| PubMed ID: 25686733	2015
Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors. The Journal of biological chemistry\| PubMed ID: 26221036	2015
Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors. The Journal of biological chemistry\| PubMed ID: 26242733	2015
Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A₂ are the Main Venom Components. Toxins\| PubMed ID: 27077884	2016
Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 27576061	2016
Cobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom. Toxins\| PubMed ID: 28878143	2017
Impact of membrane partitioning on the spatial structure of an S-type cobra cytotoxin. Journal of biomolecular structure & dynamics\| PubMed ID: 28990854	2018
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. PloS one\| PubMed ID: 29023569	2017
Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom. Toxins\| PubMed ID: 29072627	2017
Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant. Toxins\| PubMed ID: 29316656	2018
Brain and Quantum Dots: Benefits of Nanotechnology for Healthy and Diseased Brain. Central nervous system agents in medicinal chemistry\| PubMed ID: 30101720	2018
Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects. Bioconjugate chemistry\| PubMed ID: 30817133	2019
Novel long-chain neurotoxins from distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors. The Biochemical journal\| PubMed ID: 30944155	2019
Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS letters\| PubMed ID: 31276191	2019
Antibacterial activity of cardiotoxin-like basic polypeptide from cobra venom. Bioorganic & medicinal chemistry letters\| PubMed ID: 31870648	2020
Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression. Biomolecules\| PubMed ID: 32230846	2020
PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea sta... Journal of neurochemistry\| PubMed ID: 32248535	2020
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors. Marine drugs\| PubMed ID: 32272633	2020
Three-finger proteins from snakes and humans acting on nicotinic receptors: Old and new. Journal of neurochemistry\| PubMed ID: 32648941	2021
Snake C-type lectin-like proteins inhibit nicotinic acetylcholine receptors. Journal of venom research\| PubMed ID: 33024544	2020
Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models. Biomolecules\| PubMed ID: 33374963	2020
α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells. Marine drugs\| PubMed ID: 33669933	2021
The omega-loop of cobra cytotoxins tolerates multiple amino acid substitutions. Biochemical and biophysical research communications\| PubMed ID: 33915327	2021
Corrigendum to "The omega-loop of cobra cytotoxins tolerates multiple amino acid substitutions" [Biochem. Biophys. Res. Commun. 558 (2021) 141-146]. Biochemical and biophysical research communications\| PubMed ID: 34620492	2021
Snake venom phospholipase As exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2. Cellular and molecular life sciences : CMLS\| PubMed ID: 34714362	2021
Snake Toxins Labeled by Green Fluorescent Protein or Its Synthetic Chromophore are New Probes for Nicotinic acetylcholine Receptors. Frontiers in molecular biosciences\| PubMed ID: 34926576	2021
Effects of Cardiotoxins from Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms. Toxins\| PubMed ID: 35202116	2022
Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling. Toxins\| PubMed ID: 35202176	2022
S- and P-type cobra venom cardiotoxins differ in their action on isolated rat heart. The journal of venomous animals and toxins including tropical diseases\| PubMed ID: 35432493	2022
Synthetic Analogs of 6-Bromohypaphorine, a Natural Agonist of Nicotinic Acetylcholine Receptors, Reduce Cardiac Reperfusion Injury in a Rat Model of Myocardial Ischemia. Doklady. Biochemistry and biophysics\| PubMed ID: 35538277	2022
Comparative Study of the Effect of Snake Venoms on the Growth of Ciliates Tetrahymena pyriformis: Identification of Venoms with High Antiprotozoal Activity. Doklady. Biochemistry and biophysics\| PubMed ID: 35538287	2022
Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy. Toxins\| PubMed ID: 36548736	2022
Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop. Toxins\| PubMed ID: 36668826	2022
New Plant Species Showing Antiprotozoian Activity. Doklady. Biochemistry and biophysics\| PubMed ID: 36786997	2022
The Potassium Channel Blocker β-Bungarotoxin from the Krait Venom Manifests Antiprotozoal Activity. Biomedicines\| PubMed ID: 37189733	2023
Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types. International journal of molecular sciences\| PubMed ID: 37298207	2023
Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia. Doklady. Biochemistry and biophysics\| PubMed ID: 37700213	2023
Anti-smoking drugs cytisine and varenicline reduce cardiac reperfusion injury in rat model of myocardial ischemia. Biochimie\| PubMed ID: 37871826	2024
Erratum to: Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia. Doklady. Biochemistry and biophysics\| PubMed ID: 38267779	2023
Analysis of intra-specific variations in the venom of individual snakes based on Raman spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy\| PubMed ID: 38579426	2024
Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins. Toxins\| PubMed ID: 38922156	2024
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA in Model Myelin Membranes: Pharmacological Relevance. The Journal of membrane biology\| PubMed ID: 39438323	2025
Non-conventional toxin WTX and its disulfide-fixed synthetic fragments: Interaction with nicotinic acetylcholine receptors and reduction of blood pressure. International journal of biological macromolecules\| PubMed ID: 39667465	2025
Diverse β-bungarotoxin isoforms manifest different affinities to voltage-gated potassium channels of Kv1.x subfamily. Archives of biochemistry and biophysics\| PubMed ID: 40287033	2025
Intravenous Administration of Heterodimeric Phospholipase A2 HDP-1 Disturbs Cardiovascular System Functions and Biochemical Composition of Blood in Anesthetized Rats. Doklady. Biochemistry and biophysics\| PubMed ID: 40353963	2025
Cobra Three-Finger Toxins Interact with RNA and DNA: Nucleic Acids as Their Putative Biological Targets. International journal of molecular sciences\| PubMed ID: 40362528	2025