assessing-primary-motor-cortex-excitability-excitability-modulation

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

We describe a protocol to assess motor cortex excitability and its modulation, through paired use of electromyography (EMG) and repetitive transcranial ...

conventional-repetitive-transcranial-magnetic-stimulation-for

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive approach for brain stimulation, with proven effectiveness and efficacy to treat ...

Champalimaud Foundation

Mood disorders have been associated with lateralized brain dysfunction, on the left-side for depression and right-side for mania. Consistently, asymmetry of cortical excitability, as measured by transcranial magnetic stimulation (TMS) has been reported. Here, we reviewed and summarized work assessing such measures bilaterally in mood disorders.

Hemispheric asymmetry of motor cortex excitability in mood disorders - Evidence from a systematic review and meta-analysis.

Transcranial Magnetic Stimulation (TMS) allows for cortical-excitability (CE) assessment and its modulation has been associated with neuroplasticity-like phenomena, thought to be impaired in neuropsychiatric disorders. However, the stability of these measures has been challenged, defying their potential as biomarkers. This study aimed to test the temporal stability of cortical-excitability modulation and study the impact of individual and methodological factors in determining within- and between-subject variability.

Replicability of motor cortex-excitability modulation by intermittent theta burst stimulation.

Psychedelic treatments for mental health conditions pose challenges for informed consent.

Reducing motor evoked potential amplitude variability through normalization.

Dilemmas in psychedelic medicine: From ethics to regulation and equity.

Although studies of psychedelic-assisted psychotherapy are accumulating, there is no consensus regarding best practice of the psychotherapeutic component. In this systematic review, we summarised the quality of reporting on psychological interventions in research about psychedelic treatments. The design followed PRISMA guidelines and was preregistered in PROSPERO (CRD42022319221). We searched MEDLINE, PsycINFO, and Embase for original studies on psychedelic-assisted psychotherapy and included 45 studies assessing psilocybin, 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (known as LSD), or ayahuasca, for the treatment of mental disorders. Psychological interventions were done heterogeneously across studies, and completeness of information reported about these interventions was mostly low, according to an adaptation of the Template for Intervention Description and Replication checklist. In studies including MDMA, psychotherapy was more homogeneous and more procedural details were provided. Improved reporting on psychological interventions of psychedelic treatments will support replicability, generalisability, and accurate interpretation of research, while enhancing feasibility and safety of future clinical research and real-world implementation of treatments.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Article	Year
Hemispheric asymmetry of motor cortex excitability in mood disorders - Evidence from a systematic review and meta-analysis. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology\| PubMed ID: 35240425	2022
Replicability of motor cortex-excitability modulation by intermittent theta burst stimulation. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology\| PubMed ID: 37269770	2023
Psychedelic treatments for mental health conditions pose challenges for informed consent. Nature medicine\| PubMed ID: 37316686	2023
Reducing motor evoked potential amplitude variability through normalization. Frontiers in psychiatry\| PubMed ID: 38356910	2024
Dilemmas in psychedelic medicine: From ethics to regulation and equity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 39637630	2025
Quality of reporting on psychological interventions in psychedelic treatments: a systematic review. The lancet. Psychiatry\| PubMed ID: 39667373	2025

Carolina Seybert

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