detection-targetable-alterations-non-small-cell-lung-cancer-using

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

The success of targeted therapy in non-small cell lung cancer (NSCLC) hinges on the precise identification of driver alterations, including mutations, ...

Chinese Academy of Medical Sciences and Peking Union Medical College

Isoflavones, bioactive soy compounds, are known to exhibit anticancer activities. The present study investigated the anticancer activities of isoflavones on human retinoblastoma Y79 cells  and . An MTT cell viability assay showed that the half maximal inhibitory concentration value of isoflavones against human retinoblastoma Y79 cells is 1.23 ± 0.42 μmol/l. Flow cytometry analysis indicated that isoflavones blocked G1/S progression. Western blot analysis demonstrated that the mammalian target of rapamycin (mTOR) pathway in Y79 cells was inhibited by isoflavones, with a concomitant decrease in cyclin E1, which accounted for the isoflavone-mediated G1 phase arrest. Isoflavones also inhibited human retinoblastoma growth ; western blot analysis showed inhibition of mTOR and downregulation of cyclin E1 in an isoflavone-treated xenograft mouse model. Together, these results illustrate that isoflavones inhibit retinoblastoma tumour growth  and  and that inactivation of the mTOR pathway and downregulation of cyclin E1 is involved in this action. The results of this study suggest that isoflavones could be tested as promising anti-retinoblastoma agent.

Mechanism study of isoflavones as an anti-retinoblastoma progression agent.

Breast cancer (BC) is the most common cancer among women worldwide and a leading cause of cancer-associated deaths among women. However, there is a lack of accurate prognostic biomarkers for BC. In the present study, we aimed to identify a genomic instability (GI)-associated microRNA signature as a novel potential prognostic biomarker in BC.

Genomic instability-associated two-miRNA signature as a novel prognostic biomarker in breast cancer.

This study explored the effectiveness of a Problem-based Learning (PBL) teaching model on the WeChat public platform for radiation oncology residency training programs.

Article	Year
Mechanism study of isoflavones as an anti-retinoblastoma progression agent. Oncotarget\| PubMed ID: 29179444	2017
Genomic instability-associated two-miRNA signature as a novel prognostic biomarker in breast cancer. The journal of gene medicine\| PubMed ID: 37880853	2024
Problem-based learning on the WeChat public platform in radiation oncology residency training programs. BMC medical education\| PubMed ID: 39538173	2024

Yongming Zhang

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