an-orthotopic-sciatic-nerve-xenograft-for-neurofibromatosis-type-1

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Neurofibromatosis type 1 (NF1) is a genetic disorder caused by pathogenic variants in the NF1 gene, leading to the loss of neurofibromin function and the ...

APHP (Assistance Publique-Hôpitaux de Paris)

Université Versailles Saint Quentin en Yvelines

More than 30 face transplantations have been done worldwide since 2005 but no documented long-term follow-up has been reported in the literature. We aimed to answer remaining question about the long-term risks and benefits of face transplant.

Face transplant: long-term follow-up and results of a prospective open study.

Facial transplantation: facing the limits, planning the future.

Classical bladder exstrophy (CBE), affecting 1 birth out of 30,000, is characterized by an evaginated bladder plate through a defect in the lower abdominal wall, multiple abdominal wall anomalies including a pubic bone arch dehiscence. Numerous approaches from childhood to adulthood are thus required, depending on the severity of the deformity, including the associated genital anomalies. We report the case of a 19-year-old woman with CBE with a history of three-failed primary closure. We performed a secondary neck closure with a concomitant suspension of the bladder neck and reconstruction of the lower abdominal wall using a bilateral gracilis muscle flap transposition. The early postoperative course was uneventful. The patient was discharged at day ten postoperatively. The upper part of the genital sutures (labia minora) secondary healed in three weeks. Assessment at 2, 6 and 16 months postoperatively, respectively noticed a complete healing with successful sexual intercourses, perceived gracilis contraction by the patient, and finally, recent attempts to get pregnant. Neither urinary infection nor urinary leaks occurred. Bilateral crossed gracilis muscles transfer linking both rectus abdominis muscle in front of the reconstructed bladder neck might benefit to bladder exstrophy patients.

Article	Year
Face transplant: long-term follow-up and results of a prospective open study. Lancet (London, England)\| PubMed ID: 27567680	2016
Facial transplantation: facing the limits, planning the future. Lancet (London, England)\| PubMed ID: 28379144	2017
Secondary bladder exstrophy repair with a bilateral gracilis muscle flap in an adult female patient: Case report of an original procedure. Annales de chirurgie plastique et esthetique\| PubMed ID: 29980317	2019

Mikael Hivelin

Biography

JoVE Journal Publications

Other Publications