factors-associated-with-orthostatic-hypotension-parkinson-s-disease

Factors Associated with Orthostatic Hypotension in Parkinson's Disease Patients: A Systematic Review and Meta-analysis

Orthostatic hypotension (OH) is a prevalent non-motor symptom in Parkinson&#39;s disease (PD), heightening the risk of falls and mortality. This study ...

Chengdu University of Traditional Chinese Medicine

Social isolation is a global health issue that affects older adults throughout their lives. This study aimed to identify the factors associated with social isolation in older adults.

Factors Associated With Social Isolation in Older Adults: A Systematic Review and Meta-Analysis.

Loneliness is a powerful stressor for depression in older adults, and resilience and social support may mediate this relationship, while the evidence is limited. Hence, our study aims to explore the mediating role of social support and resilience between loneliness and depression and to test possible moderators.

Mediating effect of social support and resilience between loneliness and depression in older adults: A systematic review and meta-analytic structural equation modeling.

Baduanjin is a traditional Chinese regimen involving flowing movements, breath control, and strengthening to benefit health and well-being. We investigated the effectiveness of Baduanjin for older adults with insomnia.

The effect of Baduanjin on the insomnia of older adults: A systematic review and meta-analysis.

Depression is a serious and common complication of diabetes, with a well-established link between the two conditions. Recent studies indicate that activation of the NLRP3 inflammasome in hippocampal microglia plays a key role in the pathogenesis of diabetes complicated with depression (DD). While environmental enrichment (EE) has demonstrated significant anti-neuroinflammatory effects, its potential to alleviate neuroinflammation specifically induced by DD remains unclear. The DD rat model was established using a combination of a high-fat diet, streptozotocin injection, and chronic unpredictable mild stress. The effects of EE on NLRP3 inflammasome activation in the hippocampal microglia of DD rats were examined through a series of behavioral tests (open field test, forced swim test, and elevated plus maze), along with enzyme-linked immunosorbent assays, hematoxylin and eosin staining, TdT-mediated dUTP nick-end labeling staining, Western blot analysis, and immunofluorescence. Compared to the control group, DD rats exhibited impaired glucose metabolism and increased depressive-like behaviors, alongside hippocampal neuronal damage and elevated apoptosis rates. Activation of the NLRP3 inflammasome in hippocampal microglia was observed, with upregulation of the NLRP3 signaling pathway and inhibition of the PI3K/AKT signaling pathway. EE significantly mitigated these effects, reducing hippocampal neuroinflammation and alleviating depressive behaviors in DD rats. Neuroinflammation in the hippocampus is a key mechanism underlying the pathogenesis of DD. This study demonstrated that EE reduces neuroinflammation, likely by inhibiting the activation of the NLRP3 inflammasome in hippocampal microglia.

Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.

Workplace bullying remains a pervasive concern in healthcare, with nurses reporting among the highest rates of exposure across health professions. This study explored nurses' lived experiences of workplace bullying, with particular attention to their psychological reactions, coping responses and the organisational conditions that shaped these processes. A descriptive phenomenological design was employed. Semi-structured, in-depth interviews were conducted with fourteen nurses at a tertiary hospital in China between October and December 2024. Data were analysed using Colaizzi's seven-step method. Four overarching themes were identified: (1) From emotional shock to lingering psychological trauma, (2) tensions between passive tolerance and active coping, (3) organisational climate of silence and hierarchical oppression and (4) psychological recovery and meaning reconstruction. The findings revealed that bullying induced acute and cumulative emotional distress-including anxiety, fear, helplessness and withdrawal-and prompted a range of coping behaviours such as endurance, overperformance and seeking support. Participants' responses were deeply shaped by hierarchical organisational cultures, leadership inaction, and a perceived lack of psychological safety in accessing support. These insights highlight the urgent need for healthcare institutions to implement trauma-informed, culturally responsive interventions that cultivate psychologically safe workplaces. Supporting nurses' emotional well-being is essential to fostering moral resilience, retaining workforce capacity and sustaining ethical, high-quality patient care.

Article	Year
Factors Associated With Social Isolation in Older Adults: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association\| PubMed ID: 36549651	2023
Mediating effect of social support and resilience between loneliness and depression in older adults: A systematic review and meta-analytic structural equation modeling. Journal of affective disorders\| PubMed ID: 39147150	2024
The effect of Baduanjin on the insomnia of older adults: A systematic review and meta-analysis. Geriatric nursing (New York, N.Y.)\| PubMed ID: 39305546	2024
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats. Scientific reports\| PubMed ID: 40269100	2025
Psychological Reactions and Coping Strategies in Nurses' Experiences With Workplace Bullying: A Qualitative Study. International journal of mental health nursing\| PubMed ID: 40765245	2025

Qingfang Liang

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