long-non-coding-rna-pvt1-enhances-glycolysis-thyroid-carcinoma

Long Non-Coding RNA PVT1 Enhances Glycolysis in Thyroid Carcinoma by Stabilizing HIF-1&#945; and Activating Glycolytic Gene Transcription

As the foremost endocrine system cancer, thyroid carcinoma exhibits an accelerating epidemiological trend across populations. Despite advances in ...

The Second Affiliated Hospital of Fujian Medical University

Differentiated thyroid cancer (DTC) often seriously impacts patients' lives. Radionuclide Iodine-131 (I) is widely used in treating patients with DTC. However, most patients know little about radionuclide therapy, and the treatment needs to be performed in a special isolation ward, which can cause anxiety and depression.

Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer: A cross-sectional study.

Keloid seriously affects the appearance, and is accompanied by some symptoms including pain, burning, itching. Radioactive nuclides such as P have been proved to be effective in inhibiting the formation of keloid, but the mechanism remains unclear.

Inhibition of keloid by P isotope radiotherapy through suppressing TGF-β/Smad signaling pathway.

Patients with radioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) are resistant to radioactive iodine-131(I) treatment, and the clinical treatment for these patients is complex. The implantation of iodine-125 (I) seeds in the lesion has been successfully applied to treat malignant tumors, but there are few reports on using I particles in the treatment of RAIR-DTC. This retrospective study collected data of 92 patients with RAIR-DTC. Patients treated with sorafenib were included in a control group (50 cases with 72 lesions) and patients treated with I implantation were included in an observation group (42 cases with 68 lesions). The results showed that compared with those in the control group, the lesion volume was lower and the VVR was higher in the observation group (<0.05). The Tg and Tg-Ab levels 6 months after treatment were lower than those before treatment in both groups, and the post-treatment Tg and Tg-Ab levels of the observation group were lower than those of the control group (<0.05). The efficacy, disease control rate, and objective remission rate were not significantly different between the observation group and the control group (>0.05). Overall survival of patients in the observation group was longer than that in the control group, χ = 4.430,  = 0.035. The incidence of total adverse reactions in the observation group was lower than that in the control group (<0.05). In conclusion, I seed implantation is effective in RAIR-DTC treatment as it can prolong the overall survival of patients while maintaining a safe profile.

Clinical efficacy of iodine-125 (I) seed implantation in patients with iodine-refractory differentiated thyroid cancer.

MutT homolog 1 (MTH1) sanitizes oxidized dNTP pools to promote the survival of cancer cells and its expression is frequently upregulated in cancers. Polyubiquitination stabilizes MTH1 to facilitate the proliferation of melanoma cells, suggesting the ubiquitin system controls the stability and function of MTH1. However, whether ubiquitination regulates MTH1 in gastric cancers has not been well defined. This study aims to investigate the interaction between MTH1 and a deubiquitinase, USP9X, in regulating the proliferation, survival, migration, and invasion of gastric cancer cells.

USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1.

Lymph node metastasis is closely associated with the prognosis of patients with non-small cell lung cancer (NSCLC). This study aimed to evaluate the role of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters in mediastinal lymph node metastasis in NSCLC.

Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer.

To evaluate liver function using dynamic hepatobiliary single-photon emission computed tomography (SPECT) in different rat models of acute liver failure.

Article	Year
Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer: A cross-sectional study. World journal of psychiatry\| PubMed ID: 37547735	2023
Inhibition of keloid by P isotope radiotherapy through suppressing TGF-β/Smad signaling pathway. Aging\| PubMed ID: 37910782	2023
Clinical efficacy of iodine-125 (I) seed implantation in patients with iodine-refractory differentiated thyroid cancer. American journal of cancer research\| PubMed ID: 37970343	2023
USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1. BMC gastroenterology\| PubMed ID: 39075342	2024
Predictive value of 18F-FDG PET/CT metabolic parameters for lymph node metastasis of non-small cell lung cancer. Biomarkers in medicine\| PubMed ID: 39717963	2025
Assessing Liver Function in Rat Models of Acute Liver Failure Using Single-Photon Emission Computed Tomography and Cytokine Levels. PloS one\| PubMed ID: 40333907	2025

Yingrui Su

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