Mark Dunstan

Manchester Institute of Biotechnology (MIB), University of Manchester

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Coevolution of protein and RNA structures within a highly conserved ribosomal domain. Chemistry & biology\| PubMed ID: 15734647	2005
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. The Journal of biological chemistry\| PubMed ID: 19369248	2009
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). Journal of medicinal chemistry\| PubMed ID: 19877692	2009
Reengineering orthogonally selective riboswitches. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133756	2010
Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones. Journal of medicinal chemistry\| PubMed ID: 21859103	2011
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature\| PubMed ID: 21892188	2011
In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-κB signaling. Molecular cancer therapeutics\| PubMed ID: 22090421	2012
Heterologous expression, purification and cofactor reconstitution of the reductive dehalogenase PceA from Dehalobacter restrictus. Protein expression and purification\| PubMed ID: 22940504	2012
The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 23479753	2013
Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 23897483	2013
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities. Nature communications\| PubMed ID: 23917065	2013
Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species. Journal of the American Chemical Society\| PubMed ID: 24971878	2014
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation. Nature\| PubMed ID: 25327251	2015
Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 26327380	2015
Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification. The Journal of biological chemistry\| PubMed ID: 26378237	2015
SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. Biochemical Society transactions\| PubMed ID: 27284023	2016
Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic & biomolecular chemistry\| PubMed ID: 27714222	2016
biochem4j: Integrated and extensible biochemical knowledge through graph databases. PloS one\| PubMed ID: 28708831	2017
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis. Nature chemical biology\| PubMed ID: 28719588	2017
Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides. Angewandte Chemie (International ed. in English)\| PubMed ID: 28940631	2017
Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes. Scientific reports\| PubMed ID: 29057979	2017
Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase. ACS catalysis\| PubMed ID: 29750129	2018
Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase. Angewandte Chemie (International ed. in English)\| PubMed ID: 29791083	2018
PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts. Bioinformatics (Oxford, England)\| PubMed ID: 29949952	2018
Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction. Methods in enzymology\| PubMed ID: 30173770	2018
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals. Communications biology\| PubMed ID: 30271948	2018
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli. ACS synthetic biology\| PubMed ID: 30563328	2019
SelProm: A Queryable and Predictive Expression Vector Selection Tool for . ACS synthetic biology\| PubMed ID: 30870592	2019
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism. Nature\| PubMed ID: 31132786	2019
An automated pipeline for the screening of diverse monoterpene synthase libraries. Scientific reports\| PubMed ID: 31417136	2019
Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain. Journal of molecular biology\| PubMed ID: 31874150	2020
Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers. Metabolic engineering\| PubMed ID: 32335188	2020
Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries. Synthetic biology (Oxford, England)\| PubMed ID: 32995546	2019
Engineering towards production of gatekeeper (2)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol. Synthetic biology (Oxford, England)\| PubMed ID: 33195815	2020
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli. Microbial biotechnology\| PubMed ID: 33710766	2021
Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets. Biochemical Society transactions\| PubMed ID: 34100907	2021
SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35727444	2022