laparoscopic-anatomical-right-anterior-sectionectomy-with-hepatic

Laparoscopic Anatomical Right Anterior Sectionectomy with a Hepatic Pedicle-first Approach: Technical Details and Representative Case Illustration

Laparoscopic anatomical right anterior sectionectomy remains technically demanding due to intricate hepatic anatomy and the need to preserve segmental ...

Central South University

Liver cancer ranks as the sixth most prevalent malignancy globally, with Hepatocellular Carcinoma (HCC) constituting the predominant subtype, thereby imposing a significant burden on public health and presenting limited therapeutic options. Despite ongoing efforts to innovate treatment modalities, anti-angiogenesis therapy continues to be the primary strategy for managing HCC. Angiogenesis is a pivotal process within the tumor microenvironment, characterized by the formation of new blood vessels that provide essential nutrients and oxygen to proliferating tumors, thereby facilitating their growth and potential metastasis. Numerous angiogenic signaling pathways become dysregulated during this process. Targeting these aberrant pathways can yield significant therapeutic benefits for patients and may even reverse drug resistance. However, these signaling pathways frequently demonstrate intricate crosstalk and interconnections. Elucidating these interactions could represent a crucial strategy for advancing the treatment of HCC. This review provides both mechanistic insights into angiogenic network plasticity and translational strategies to overcome therapeutic bottlenecks in HCC management.

Aberrant angiogenic signaling in HCC: therapeutic targeting and drug resistance.

Aspirin and statins are often taken together in clinical practice. The impact of combined use of aspirin and statin (CAS) therapy on individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) or advanced liver fibrosis (LF) remains uncertain. This study is aimed at exploring their associations in US adults.

Combined Use of Aspirin and Statins Is Associated With Increased Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Study From National Health and Nutrition Examination Survey.

Article	Year
Aberrant angiogenic signaling in HCC: therapeutic targeting and drug resistance. Frontiers in oncology\| PubMed ID: 40606973	2025
Combined Use of Aspirin and Statins Is Associated With Increased Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Study From National Health and Nutrition Examination Surv... Gastroenterology research and practice\| PubMed ID: 41089296	2025

Zhengwu Jiang

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