Anna Rodina

Chemical Biology Program, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17517623	2007
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature chemical biology\| PubMed ID: 17603540	2007
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment? BMC neuroscience\| PubMed ID: 19090995	2008
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416831	2009
Heat shock protein 90 in neurodegenerative diseases. Molecular neurodegeneration\| PubMed ID: 20525284	2010
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. The Journal of clinical investigation\| PubMed ID: 20852385	2010
Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators. Assay and drug development technologies\| PubMed ID: 21133677	2011
Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorganic & medicinal chemistry\| PubMed ID: 21459002	2011
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature chemical biology\| PubMed ID: 21946277	2011
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein journal of organic chemistry\| PubMed ID: 23616796	2013
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood\| PubMed ID: 23943653	2013
Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series. Journal of medicinal chemistry\| PubMed ID: 23965125	2013
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chemistry & biology\| PubMed ID: 24239008	2013
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of medicinal chemistry\| PubMed ID: 24548207	2014
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric si... Journal of medicinal chemistry\| PubMed ID: 24548239	2014
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS chemical biology\| PubMed ID: 24934503	2014
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species. Cell reports\| PubMed ID: 26628369	2015
The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature\| PubMed ID: 27706135	2016
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma. Molecular cancer therapeutics\| PubMed ID: 28619753	2017
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nature communications\| PubMed ID: 30341316	2018
Chaperome heterogeneity and its implications for cancer study and treatment. The Journal of biological chemistry\| PubMed ID: 30409908	2019
A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond. Cold Spring Harbor perspectives in biology\| PubMed ID: 30936118	2020
Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Cancer cell\| PubMed ID: 31668946	2019
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nature communications\| PubMed ID: 31949159	2020
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell reports\| PubMed ID: 32610141	2020
Measuring Tumor Epichaperome Expression Using [I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer. JCO precision oncology\| PubMed ID: 33283132	2020
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nature communications\| PubMed ID: 34344873	2021
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer. Communications biology\| PubMed ID: 34824367	2021
How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view. Structure (London, England : 1993)\| PubMed ID: 37343552	2023
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation. Nature communications\| PubMed ID: 37353488	2023
Use of Native-PAGE for the Identification of Epichaperomes in Cell Lines. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 37540435	2023
Experimental traumatic brain injury increases epichaperome formation. Neurobiology of disease\| PubMed ID: 37863370	2023
Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation. Research square\| PubMed ID: 38645031	2024
Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders. Biomedicines\| PubMed ID: 38927459	2024
N-Glycosylation-Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 39042517	2024
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation. Nature communications\| PubMed ID: 39414766	2024
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum. Research square\| PubMed ID: 39989971	2025