Sahil Sharma

Chemical Biology Program, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Adapting to stress - chaperome networks in cancer. Nature reviews. Cancer\| PubMed ID: 29795326	2018
Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate. Tetrahedron letters\| PubMed ID: 30026636	2017
A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond. Cold Spring Harbor perspectives in biology\| PubMed ID: 30936118	2020
Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins\| PubMed ID: 31141217	2019
Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs. ACS chemical biology\| PubMed ID: 32191434	2020
Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies. Methods in enzymology\| PubMed ID: 32475406	2020
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell reports\| PubMed ID: 32610141	2020
Tailored Quinolines Demonstrate Flexibility to Exert Antitumor Effects through Varied Mechanisms-A Medicinal Perspective. Anti-cancer agents in medicinal chemistry\| PubMed ID: 32900354	2021
Disease-specific interactome alterations via epichaperomics: the case for Alzheimer's disease. The FEBS journal\| PubMed ID: 34028172	2022
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. NPJ precision oncology\| PubMed ID: 34040147	2021
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nature communications\| PubMed ID: 34344873	2021
The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders. Journal of neurochemistry\| PubMed ID: 34657288	2021
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer. Communications biology\| PubMed ID: 34824367	2021
Synthesis of I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice. STAR protocols\| PubMed ID: 35496791	2022
Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes. Trends in pharmacological sciences\| PubMed ID: 36414432	2023
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation. Nature communications\| PubMed ID: 37353488	2023
Use of Native-PAGE for the Identification of Epichaperomes in Cell Lines. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 37540435	2023
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties. Genes & development\| PubMed ID: 37704377	2023
Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action. Biomedicines\| PubMed ID: 37892973	2023
2023 Canadian Surgery Forum: Sept. 20-23, 2023. Canadian journal of surgery. Journal canadien de chirurgie\| PubMed ID: 38173057	2023
N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease. Biomolecules\| PubMed ID: 38540703	2024
Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation. Research square\| PubMed ID: 38645031	2024
Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders. Biomedicines\| PubMed ID: 38927459	2024
N-Glycosylation-Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 39042517	2024
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation. Nature communications\| PubMed ID: 39414766	2024
2024 Canadian Surgery Forum: Sept. 25-28, 2024. Canadian journal of surgery. Journal canadien de chirurgie\| PubMed ID: 39609036	2024
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum. Research square\| PubMed ID: 39989971	2025
Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases. RSC chemical biology\| PubMed ID: 40144950	2025
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease. Trends in biochemical sciences\| PubMed ID: 40877054	2025