Mark J. I. Paine

Vector Group, liverpool school of tropical medicine

Affiliated withliverpool school of tropical medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS genetics\| PubMed ID: 19043575	2008
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. Insect biochemistry and molecular biology\| PubMed ID: 21324359	2011
Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22460795	2012
Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance. PLoS neglected tropical diseases\| PubMed ID: 22479665	2012
A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection. Insect biochemistry and molecular biology\| PubMed ID: 22732326	2012
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23248325	2013
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24248381	2013
CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae. PLoS genetics\| PubMed ID: 24651294	2014
Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae. PloS one\| PubMed ID: 24675797	2014
Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu. Malaria journal\| PubMed ID: 24885084	2014
DDT-based indoor residual spraying suboptimal for visceral leishmaniasis elimination in India. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26124110	2015
Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector. PLoS genetics\| PubMed ID: 26517127	2015
Development of a Simple Dipstick Assay for Operational Monitoring of DDT. PLoS neglected tropical diseases\| PubMed ID: 26760773	2016
Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India. Parasites & vectors\| PubMed ID: 26812963	2016
Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae. Insect biochemistry and molecular biology\| PubMed ID: 27613592	2016
Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction. Insect biochemistry and molecular biology\| PubMed ID: 29729387	2018
Development of a rapid field-applicable molecular diagnostic for knockdown resistance (kdr) markers in An. gambiae. Parasites & vectors\| PubMed ID: 29776379	2018
Antimalarial activity of primaquine operates via a two-step biochemical relay. Nature communications\| PubMed ID: 31324806	2019
Cross-resistance profiles of malaria mosquito P450s associated with pyrethroid resistance against WHO insecticides. Pesticide biochemistry and physiology\| PubMed ID: 31685198	2019
Improving the performance of spray operators through monitoring and evaluation of insecticide concentrations of pirimiphos-methyl during indoor residual spraying for malaria control on Bioko... Malaria journal\| PubMed ID: 31964374	2020
New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids. Scientific reports\| PubMed ID: 33004954	2020
High concentrations of membrane-fed ivermectin are required for substantial lethal and sublethal impacts on Aedes aegypti. Parasites & vectors\| PubMed ID: 33407825	2021
High pyrethroid/DDT resistance in major malaria vector Anopheles coluzzii from Niger-Delta of Nigeria is probably driven by metabolic resistance mechanisms. PloS one\| PubMed ID: 33705436	2021
Improving houses in the Bolivian Chaco increases effectiveness of residual insecticide spraying against infestation with Triatoma infestans, vector of Chagas disease. Tropical medicine & international health : TM & IH\| PubMed ID: 34114721	2021
Indoor residual spraying practices against Triatoma infestans in the Bolivian Chaco: contributing factors to suboptimal insecticide delivery to treated households. Parasites & vectors\| PubMed ID: 34134775	2021
Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes. Insects\| PubMed ID: 34564266	2021
Biochemical profiling of functionally expressed CYP6P9 variants of the malaria vector Anopheles funestus with special reference to cytochrome b and its role in pyrethroid and coumarin substr... Pesticide biochemistry and physiology\| PubMed ID: 35249659	2022
Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector with special reference to cytochrome P450-mediated detoxification. Current research in parasitology & vector-borne diseases\| PubMed ID: 35284893	2021
A high-throughput HPLC method for simultaneous quantification of pyrethroid and pyriproxyfen in long-lasting insecticide-treated nets. Scientific reports\| PubMed ID: 35690679	2022
Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for antimalarial interventi... Molecular ecology\| PubMed ID: 35775282	2022
Sequential phase I metabolism of pyrethroids by duplicated CYP6P9 variants results in the loss of the terminal benzene moiety and determines resistance in the malaria mosquito Anopheles fune... Insect biochemistry and molecular biology\| PubMed ID: 35870762	2022
Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT-resistant Anopheles stephensi strain from India. Scientific reports\| PubMed ID: 36284104	2022
Resilience of transfluthrin to oxidative attack by duplicated CYP6P9 variants known to confer pyrethroid resistance in the major malaria mosquito Anopheles funestus. Pesticide biochemistry and physiology\| PubMed ID: 36963931	2023
Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers. Scientific reports\| PubMed ID: 37644079	2023
Author Correction: New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids. Scientific reports\| PubMed ID: 37803164	2023
Author Correction: Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers. Scientific reports\| PubMed ID: 37973988	2023
Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae. Malaria journal\| PubMed ID: 39844288	2025
Safety and Efficacy of Incorporating Actellic 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda. Tropical medicine and infectious disease\| PubMed ID: 39852655	2024
Significant variations in tolerance to clothianidin and pirimiphos-methyl in and populations during a dramatic malaria resurgence despite sustained indoor residual spraying in Uganda. bioRxiv : the preprint server for biology\| PubMed ID: 40027642	2025
Significant variations in tolerance to clothianidin and pirimiphos-methyl in Anopheles gambiae and Anopheles funestus populations during a dramatic malaria resurgence despite sustained indoo... Parasites & vectors\| PubMed ID: 40551263	2025