Francesca E. Duncan

Department of Obstetrics and Gynecology, Northwestern University

Affiliated withNorthwestern University Northwestern University, Chicago

Research Area

Biography

Francesca E. Duncan has not added Biography.
If you are Francesca E. Duncan and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2025
Publication title	2026

Other Publications

Article	Year
Gene expression profiling of mouse oocytes and preimplantation embryos. Methods in enzymology\| PubMed ID: 20699155	2010
The Gynecologist Has a Unique Role in Providing Oncofertility Care to Young Cancer Patients. US obstetrics & gynaecology\| PubMed ID: 21927621	2011
Bipolar-to-monopolar spindle collapse in human eggs. Molecular reproduction and development\| PubMed ID: 22777649	2012
Chromosome cohesion decreases in human eggs with advanced maternal age. Aging cell\| PubMed ID: 22823533	2012
Future Directions in Oncofertility and Fertility Preservation: A Report from the 2011 Oncofertility Consortium Conference. Journal of adolescent and young adult oncology\| PubMed ID: 23610740	2013
Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation. Biology of reproduction\| PubMed ID: 24501176	2014
A small field for fertile science: the low visibility of reproductive science in high impact journals. Journal of assisted reproduction and genetics\| PubMed ID: 24652516	2014
Keeping reproductive science visible, viable, and valuable-a call to rethink how we publish. Journal of assisted reproduction and genetics\| PubMed ID: 24677209	2014
Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. Journal of assisted reproduction and genetics\| PubMed ID: 24845158	2014
Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nature chemistry\| PubMed ID: 25615666	2015
Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening. Reproduction, fertility, and development\| PubMed ID: 25689754	2015
Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg. Journal of assisted reproduction and genetics\| PubMed ID: 25758987	2015
The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 25903945	2015
Size-specific follicle selection improves mouse oocyte reproductive outcomes. Reproduction (Cambridge, England)\| PubMed ID: 26116002	2015
Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis. Biology of reproduction\| PubMed ID: 26246221	2015
Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods. Journal of adolescent and young adult oncology\| PubMed ID: 26697267	2015
Next Generation Sequencing-Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos. Biology of reproduction\| PubMed ID: 26911429	2016
The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development. Scientific reports\| PubMed ID: 26987302	2016
The zinc spark is an inorganic signature of human egg activation. Scientific reports\| PubMed ID: 27113677	2016
Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction (Cambridge, England)\| PubMed ID: 27491879	2016
Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice. Reproduction (Cambridge, England)\| PubMed ID: 27492079	2016
Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 28102396	2017
mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28270607	2017
The sweet side of the cell cycle. Biochemical Society transactions\| PubMed ID: 28408472	2017
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Nature communications\| PubMed ID: 28509899	2017
Egg Quality during the Pubertal Transition-Is Youth All It's Cracked Up to Be? Frontiers in endocrinology\| PubMed ID: 28928717	2017
Age-associated dysregulation of protein metabolism in the mammalian oocyte. Aging cell\| PubMed ID: 28994181	2017
Mitochondrial DNA content is associated with ploidy status, maternal age, and oocyte maturation methods in mouse blastocysts. Journal of assisted reproduction and genetics\| PubMed ID: 29063991	2017
Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative. Future oncology (London, England)\| PubMed ID: 29345507	2018
Mammalian oogenesis and female reproductive aging. Aging\| PubMed ID: 29410392	2018
Radiation-induced ovarian follicle loss occurs without overt stromal changes. Reproduction (Cambridge, England)\| PubMed ID: 29636407	2018
Revisiting the scientific method to improve rigor and reproducibility of immunohistochemistry in reproductive science. Biology of reproduction\| PubMed ID: 29688318	2018
Quantifying the growth of oncofertility. Biology of reproduction\| PubMed ID: 30101292	2018
Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary. Journal of ovarian research\| PubMed ID: 30165884	2018
The use of a virtual journal club to promote cross-cultural learning in the reproductive sciences. Journal of assisted reproduction and genetics\| PubMed ID: 30246222	2018
The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond. Future oncology (London, England)\| PubMed ID: 30474429	2018
Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility. Reproduction (Cambridge, England)\| PubMed ID: 30620721	2019
Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation. Theriogenology\| PubMed ID: 30639695	2019
Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization. Molecular reproduction and development\| PubMed ID: 30793403	2019
Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue. Reproductive biology and endocrinology : RB&E\| PubMed ID: 31189477	2019
Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†. Biology of reproduction\| PubMed ID: 31436294	2020
Recombinant FSH glycoforms are bioactive in mouse preantral ovarian follicles. Reproduction (Cambridge, England)\| PubMed ID: 31600726	2019
Tissue-specific Fixation Methods Are Required for Optimal In Situ Visualization of Hyaluronan in the Ovary, Kidney, and Liver. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 31714169	2020
The long view: Considering spindle orientation in image analysis. Molecular reproduction and development\| PubMed ID: 31951056	2020
Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro. International journal of molecular sciences\| PubMed ID: 32033185	2020
Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs. Molecular human reproduction\| PubMed ID: 32119740	2020
In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†. Biology of reproduction\| PubMed ID: 32406908	2020
Ovulation and ovarian wound healing are impaired with advanced reproductive age. Aging\| PubMed ID: 32407290	2020
Spatial Analysis of Growing Follicles in the Human Ovary to Inform Tissue Engineering Strategies. Tissue engineering. Part A\| PubMed ID: 32598235	2020
Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation. iScience\| PubMed ID: 32615472	2020
Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals. Molecular human reproduction\| PubMed ID: 33022047	2020
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices. Aging cell\| PubMed ID: 33079460	2020
Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary. Reproduction (Cambridge, England)\| PubMed ID: 33258461	2021
A View from the past into our collective future: the oncofertility consortium vision statement. Journal of assisted reproduction and genetics\| PubMed ID: 33405006	2021
Emerging Roles for the Nucleolus 2019. The Journal of biological chemistry\| PubMed ID: 33509595	2020
Dental resins used in 3D printing technologies release ovo-toxic leachates. Chemosphere\| PubMed ID: 33515896	2021
Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†. Biology of reproduction\| PubMed ID: 33524104	2021
A decellularized oocyte-derived scaffold provides a "sperm safe" to preserve mammalian spermatozoa. Andrology\| PubMed ID: 33565255	2021
Autonomous follicle growth and the production of mature human eggs in vitro: with or without the ovary? Human reproduction (Oxford, England)\| PubMed ID: 33681977	2021
Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival. Reproduction (Cambridge, England)\| PubMed ID: 33764899	2021
Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid. International journal of molecular sciences\| PubMed ID: 34063149	2021
Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice. Frontiers in cell and developmental biology\| PubMed ID: 34222262	2021
Hyaluronan and Collagen Are Prominent Extracellular Matrix Components in Bovine and Porcine Ovaries. Genes\| PubMed ID: 34440360	2021
Ex vivo recovery of mature eggs from unstimulated ovaries in pediatric fertility preservation: proceed with caution. F&S reports\| PubMed ID: 34553149	2021
Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila. Trends in cell biology\| PubMed ID: 34922803	2022
Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality. Biology of reproduction\| PubMed ID: 34982142	2022
Broadening the educational pipeline: the global landscape of master of science programs in reproductive science and medicine. Biology of reproduction\| PubMed ID: 35639631	2022
Quantitative morphokinetic parameters identify novel dynamics of oocyte meiotic maturation and cumulus expansion†. Biology of reproduction\| PubMed ID: 35810327	2022
A synopsis of global frontiers in fertility preservation. Journal of assisted reproduction and genetics\| PubMed ID: 35870095	2022
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation. Reproduction (Cambridge, England)\| PubMed ID: 35899878	2022
Correction to: A synopsis of global frontiers in fertility preservation. Journal of assisted reproduction and genetics\| PubMed ID: 35920992	2022
Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth. Molecular human reproduction\| PubMed ID: 36069625	2022
Recapitulating folliculogenesis and oogenesis outside the body: encapsulated in vitro follicle growth†. Biology of reproduction\| PubMed ID: 36136744	2023
Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm. American journal of obstetrics and gynecology\| PubMed ID: 36191605	2023
Editorial: Germ cell development and reproductive aging. Frontiers in cell and developmental biology\| PubMed ID: 36313559	2022
Zinc dynamics regulate early ovarian follicle development. The Journal of biological chemistry\| PubMed ID: 36423685	2023
An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates†. Biology of reproduction\| PubMed ID: 36708230	2023
Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women. Environment international\| PubMed ID: 36724714	2023
Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status. Journal of assisted reproduction and genetics\| PubMed ID: 37012451	2023
Associations of childhood allergies with parental reproductive and allergy history. Journal of assisted reproduction and genetics\| PubMed ID: 37133690	2023
Common mechanisms of physiological and pathological rupture events in biology: novel insights into mammalian ovulation and beyond. Biological reviews of the Cambridge Philosophical Society\| PubMed ID: 37157877	2023
FGF2, LIF, and IGF1 (FLI) supplementation during human in vitro maturation enhances markers of gamete competence. Human reproduction (Oxford, England)\| PubMed ID: 37608600	2023
CD38 regulates ovarian function and fecundity via NAD metabolism. iScience\| PubMed ID: 37822499	2023
Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan. Aging cell\| PubMed ID: 37850336	2023
Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development. Development (Cambridge, England)\| PubMed ID: 37870089	2023
Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature. Aging\| PubMed ID: 37899138	2023
Human follicular fluid elicits select dose- and age-dependent effects on mouse oocytes and cumulus-oocyte complexes in a heterologous in vitro maturation assay. Molecular human reproduction\| PubMed ID: 37950499	2023
Follicular fluid aids cell adhesion, spreading in an age independent manner and shows an age-dependent effect on DNA damage in fallopian tube epithelial cells. Heliyon\| PubMed ID: 38501015	2024
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease†. Biology of reproduction\| PubMed ID: 38609185	2024
The oocyte microenvironment is altered in adolescents compared to oocyte donors. bioRxiv : the preprint server for biology\| PubMed ID: 38617323	2024
The severity of meiotic aneuploidy is associated with altered morphokinetic variables of mouse oocyte maturation. Human reproduction open\| PubMed ID: 38764910	2024
SenNet recommendations for detecting senescent cells in different tissues. Nature reviews. Molecular cell biology\| PubMed ID: 38831121	2024
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse. bioRxiv : the preprint server for biology\| PubMed ID: 38979191	2024
Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis. Molecular human reproduction\| PubMed ID: 39037927	2024
Three-Dimensionally Printed Agarose Micromold Supports Scaffold-Free Mouse Ex Vivo Follicle Growth, Ovulation, and Luteinization. Bioengineering (Basel, Switzerland)\| PubMed ID: 39061801	2024
The oocyte microenvironment is altered in adolescents compared to oocyte donors. Human reproduction open\| PubMed ID: 39211054	2024
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse. GeroScience\| PubMed ID: 39285140	2025
Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation. Communications biology\| PubMed ID: 39443665	2024
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan. eLife\| PubMed ID: 39480006	2024
Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop. Fertility and sterility\| PubMed ID: 39549739	2025
Hallmarks of female reproductive aging in physiologic aging mice. Nature aging\| PubMed ID: 39672896	2024
The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review. bioRxiv : the preprint server for biology\| PubMed ID: 39677695	2024
Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 39932386	2025
Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells. Reproduction (Cambridge, England)\| PubMed ID: 40111977	2025
Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations. Aging\| PubMed ID: 40413724	2025
A Comprehensive Multiomics Signature of Doxorubicin-Induced Cellular Senescence in the Postmenopausal Human Ovary. Aging cell\| PubMed ID: 40452152	2025
Inorganic profiles of preimplantation embryos reveal a role for zinc in blastocyst development. bioRxiv : the preprint server for biology\| PubMed ID: 40463183	2025
Ovarian aging: a missing diagnosis in reproductive medicine. Nature medicine\| PubMed ID: 40481207	2025
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures. PLoS biology\| PubMed ID: 40550000	2025
Single-cell and spatiotemporal profile of ovulation in the mouse ovary. PLoS biology\| PubMed ID: 40554460	2025
The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review†. Biology of reproduction\| PubMed ID: 40626913	2025