high-plex-imaging-using-spectral-confocal-microscopy-to-minimize-non

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence

Highly multiplexed imaging enables the study of functionally diverse cells and their niches within their native tissue environments. Iterative Bleaching ...

McMaster University Medical Centre

The authors tested the hypothesis that certain maneuvers (neck flexion/extension and head protrusion/retrusion) alter the appearance of the submental area, jawline, and melolabial groove. They used a questionnaire survey of 20 naïve judges who assessed a standardized photograph album of three subjects. The subjects' faces (frontal and lateral views) were photographed in neutral, neck flexion/extension, and head protrusion/retrusion positions. High Kendall coefficients of correlation were observed in 10 of 12 questions evaluating an improvement in jawline definition with neck extension or head protrusion, as well as in 11 of 12 questions assessing decreased submental soft tissue. All questions relating to the melolabial groove had a correlation coefficient of less than 0.70. Small changes in patient positioning during photodocumentation for facial plastic surgical procedures can cause dramatic changes in the appearance of certain parameters. Standardizing patient positioning for preoperative and postoperative photographs is imperative.

Pitfalls of nonstandardized photography in facial plastic surgery patients.

ACP Journal Club. Prednisolone, but not valacyclovir, reduced time to complete recovery of facial-nerve function in Bell palsy.

&#x307E;&#x308C;&#x3067;&#x3059;&#x304C;&#x3001;sinogenic &#x982D;&#x84CB;&#x5185;&#x786C;&#x819C;&#x5916;&#x524D;&#x982D;&#x81BF;&#x760D;&#x306F;&#x6DF1;&#x523B;&#x3067;&#x6F5C;&#x5728;&#x7684;&#x306B;&#x751F;&#x547D;&#x3092;&#x8105;&#x304B;&#x3059;&#x5408;&#x4F75;&#x75C7;&#x526F;&#x9F3B;&#x8154;&#x708E;&#x306E;&#x307E;&#x307E;&#x3067;&#x3059;&#x3002;&#x4F1D;&#x7D71;&#x7684;&#x306A;&#x7642;&#x6CD5;&#x306B;&#x306F;&#x3001;&#x9759;&#x8108;&#x5185;&#x6297;&#x751F;&#x7269;&#x8CEA;&#x3001;&#x526F;&#x9F3B;&#x8154;&#x624B;&#x8853;&#x3068;&#x8133;&#x795E;&#x7D4C;&#x5916;&#x79D1;&#x6392;&#x6C34;&#x5916;&#x90E8;&#x30A2;&#x30D7;&#x30ED;&#x30FC;&#x30C1;&#x3092;&#x901A;&#x3058;&#x3066;&#x306E;&#x7D44;&#x307F;&#x5408;&#x308F;&#x305B;&#x304C;&#x542B;&#x307E;&#x308C;&#x307E;&#x3059;&#x3002;

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&#xBE44;&#xB85D; &#xB4DC;&#xBB38;, sinogenic intracranial &#xACBD; &#xB9C9; &#xC678; &#xC815;&#xBA74; &#xB18D; &#xCD95; &#xB18D; &#xC99D;&#xC758; &#xC2EC;&#xAC01; &#xD558; &#xACE0; &#xC7A0;&#xC7AC;&#xC801;&#xC73C;&#xB85C; &#xC0DD;&#xBA85;&#xC744; &#xC704;&#xD611; &#xD569;&#xBCD1;&#xC99D; &#xB0A8;&#xC544; &#xC788;&#xC2B5;&#xB2C8;&#xB2E4;. &#xC804;&#xD1B5;&#xC801;&#xC778; &#xCE58;&#xB8CC; &#xC815; &#xB9E5; &#xD56D;&#xC0DD;&#xC81C;, &#xBD80; &#xBE44; &#xB3D9; &#xC218;&#xC220; &#xBC0F; &#xC678;&#xBD80; &#xC811;&#xADFC; &#xBC29;&#xC2DD;&#xC744; &#xD1B5;&#xD574; neurosurgical &#xBC30;&#xC218; &#xC870;&#xD569;&#xC744; &#xD3EC;&#xD568; &#xD55C;&#xB2E4;.

&#xC815;&#xBA74; &#xACBD; &#xB9C9; &#xC678; &#xB18D; &#xC591;&#xC758; &#xB0B4; &#xC2DC;&#xACBD; transnasal &#xBC30;&#xC218;&#xC785;&#xB2C8;&#xB2E4;.

Aunque sea raro, abscesos frontal epidural intracraneal de sinogenic siendo una complicaci&oacute;n grave y potencialmente mortal de la sinusitis. Terapia tradicional consiste en una combinaci&oacute;n de antibi&oacute;ticos intravenosos, cirug&iacute;a de los senos y neuroquir&uacute;rgica drenaje a trav&eacute;s de un enfoque externo.

Drenaje endosc&oacute;pico transnasal de abscesos epidurales frontales.

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Although rare, sinogenic intracranial epidural frontal abscesses remain a serious and potentially life-threatening complication of sinusitis. Traditional therapy involves a combination of intravenous antibiotics, sinus surgery, and neurosurgical drainage through an external approach.

Endoscopic transnasal drainage of frontal epidural abscesses.

Bien que rare, intracr&acirc;nienne Abc&egrave;s &eacute;pidural frontale de sinogenic restent une complication grave et potentiellement mortelle de la sinusite. Th&eacute;rapie traditionnelle implique une combinaison d&#39;antibiotiques par voie intraveineuse, la chirurgie des sinus et neurochirurgicaux drainage gr&acirc;ce &agrave; une approche externe.

TRANSNASALES endoscopique drainage d&#39;abc&egrave;s &eacute;pidurales frontales.

Obwohl selten, bleiben Sinogenic intrakranielle Abszesse, epidurale frontal eine schwerwiegende und potentiell lebensbedrohliche Komplikation der Sinusitis. Traditionelle Therapie beinhaltet eine Kombination von intraven&ouml;sen Antibiotika, Sinus Chirurgie und Neurochirurgische Drainage durch einen externen Ansatz.

Endoskopische Transnasal Entw&auml;sserung des frontalen epidurale Abszesse.

Anche se raro, sinogenic intracranica epidurale frontale ascessi rimangono una complicanza grave e potenzialmente letale di sinusite. La terapia tradizionale comporta una combinazione di antibiotici per via endovenosa, chirurgia del seno e neurochirurgica drenaggio attraverso un approccio esterno.

Transnasal endoscopica drenaggio di ascessi epidurale frontale.

Pediatric sleep disordered breathing is often caused by hypertrophy of the tonsils and is commonly managed by tonsillectomy. There is controversy regarding which postsurgical analgesic agents are safe and efficacious.

Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial.

Controversy regarding the usefulness of routine histopathological examination of bilateral nasal polyps removed during endoscopic sinus surgery to identify occult diagnoses still exists. There is a paucity of high-level evidence in the literature.

The usefulness of routine histopathology of bilateral nasal polyps - a systematic review, meta-analysis, and cost evaluation.

The goal of this study was to develop and evaluate the impact of an aviation-style challenge and response sinus surgery-specific checklist on potential safety and equipment issues during sinus surgery at a tertiary academic health center. The secondary goal was to assess the potential impact of use of the checklist on surgical times during, before, and after surgery. This initiative is designed to be utilized in conjunction with the "standard" World Health Organization (WHO) surgical checklist. Although endoscopic sinus surgery is generally considered a safe procedure, avoidable complications and potential safety concerns continue to occur. The WHO surgical checklist does not directly address certain surgery-specific issues, which may be of particular relevance for endoscopic sinus surgery.

A challenge-response endoscopic sinus surgery specific checklist as an add-on to standard surgical checklist: an evaluation of potential safety and quality improvement issues.

Endoscopic skull base surgery continues to evolve in its indications, techniques, instrumentation, and postoperative care. As surgery of the skull base will often violate dura, intraoperative and postoperative cerebrospinal fluid (CSF) leak is not uncommon and represents a potential conduit for air and bacterial contamination. Patients with obstructive sleep apnea (OSA) requiring continuous positive airway pressure (CPAP) therapy undergoing skull base surgery represent a challenging group. However, there appears to be a paucity of consensus regarding the postoperative management of this patient population. The objective of this study is to examine practice patterns and expert opinion on the use of postoperative CPAP and nasal saline in patients with OSA.

Postoperative Continuous Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern Survey.

Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1-6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns.

Article	Year
Pitfalls of nonstandardized photography in facial plastic surgery patients. Plastic and reconstructive surgery\| PubMed ID: 15220560	2004
ACP Journal Club. Prednisolone, but not valacyclovir, reduced time to complete recovery of facial-nerve function in Bell palsy. Annals of internal medicine\| PubMed ID: 19306494	2009
Endoscopic transnasal drainage of frontal epidural abscesses. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale\| PubMed ID: 22420395	2011
Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics\| PubMed ID: 25624387	2015
The usefulness of routine histopathology of bilateral nasal polyps - a systematic review, meta-analysis, and cost evaluation. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale\| PubMed ID: 26537414	2015
A challenge-response endoscopic sinus surgery specific checklist as an add-on to standard surgical checklist: an evaluation of potential safety and quality improvement issues. International forum of allergy & rhinology\| PubMed ID: 29485750	2018
Postoperative Continuous Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern Surve... American journal of rhinology & allergy\| PubMed ID: 30345806	2019
Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale\| PubMed ID: 38115030	2023

Doron D. Sommer

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