Manel Jordana

McMaster Immunology Research Centre, McMaster University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. The Journal of experimental medicine\| PubMed ID: 25071163	2014
Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity. PloS one\| PubMed ID: 25517731	2014
Replication-defective adenovirus infection reduces Helicobacter felis colonization in the mouse in a gamma interferon- and interleukin-12-dependent manner. Infection and immunity\| PubMed ID: 10456897	1999
Generation of experimental allergic airways inflammation in the absence of draining lymph nodes. The Journal of clinical investigation\| PubMed ID: 11518731	2001
On the generation of allergic airway diseases: from GM-CSF to Kyoto. Trends in immunology\| PubMed ID: 12133802	2002
Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12244139	2002
Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4. American journal of respiratory cell and molecular biology\| PubMed ID: 12356576	2002
Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization. The Journal of allergy and clinical immunology\| PubMed ID: 12743573	2003
Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation. American journal of respiratory cell and molecular biology\| PubMed ID: 12760969	2003
Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice. American journal of respiratory cell and molecular biology\| PubMed ID: 12842850	2004
GM-CSF and dendritic cells in allergic airway inflammation: basic mechanisms and prospects for therapeutic intervention. Current drug targets. Inflammation and allergy\| PubMed ID: 14561147	2003
Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15067081	2004
Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15528378	2004
Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15661930	2005
B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15728513	2005
House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. American journal of respiratory and critical care medicine\| PubMed ID: 15879422	2005
Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitizat... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16116169	2005
Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Molecular and cellular biology\| PubMed ID: 16914726	2006
Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17586699	2007
Modeling responses to respiratory house dust mite exposure. Contributions to microbiology\| PubMed ID: 17684332	2007
Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17709545	2007
Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17982059	2007
Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling. American journal of respiratory and critical care medicine\| PubMed ID: 18174546	2008
In vivo-to-in silico iterations to investigate aeroallergen-host interactions. PloS one\| PubMed ID: 18545674	2008
Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunction. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18776055	2008
TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations. Inflammation & allergy drug targets\| PubMed ID: 19075788	2008
Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19234206	2009
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. The Journal of allergy and clinical immunology\| PubMed ID: 19409603	2009
Management of food-induced anaphylaxis: unsolved challenges. Current clinical pharmacology\| PubMed ID: 19442076	2009
Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20083661	2010
Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease. American journal of respiratory and critical care medicine\| PubMed ID: 20732990	2011
A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21160052	2011
Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma. American journal of respiratory cell and molecular biology\| PubMed ID: 21317378	2011
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation. Respiratory research\| PubMed ID: 21473774	2011
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. The Journal of allergy and clinical immunology\| PubMed ID: 21624619	2011
Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22174454	2012
Critical role of natural killer cells in lung immunopathology during influenza infection in mice. The Journal of infectious diseases\| PubMed ID: 22561366	2012
IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization. The Journal of allergy and clinical immunology\| PubMed ID: 23006545	2013
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PloS one\| PubMed ID: 24551140	2014
Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology\| PubMed ID: 25878673	2015
Ecobiotherapy Rich in Firmicutes Decreases Susceptibility to Colitis in a Humanized Gnotobiotic Mouse Model. Inflammatory bowel diseases\| PubMed ID: 26060932	2015
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice. The American journal of pathology\| PubMed ID: 26456581	2015
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS pathogens\| PubMed ID: 26766566	2016
Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. PLoS pathogens\| PubMed ID: 27148737	2016
Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012-2015. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology\| PubMed ID: 28194191	2017
Lifelong memory responses perpetuate humoral T2 immunity and anaphylaxis in food allergy. The Journal of allergy and clinical immunology\| PubMed ID: 28216433	2017
Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection. The Journal of experimental medicine\| PubMed ID: 28264883	2017
CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28827285	2017
The Initiation of Th2 Immunity Towards Food Allergens. International journal of molecular sciences\| PubMed ID: 29757238	2018
Probiotics and oral immunotherapy for peanut allergy. The Lancet. Child & adolescent health\| PubMed ID: 30169173	2017
The IgE memory reservoir in food allergy. The Journal of allergy and clinical immunology\| PubMed ID: 30201515	2018
Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells. ERJ open research\| PubMed ID: 30480000	2018
Human BCR analysis of single-sorted, putative IgE memory B cells in food allergy. The Journal of allergy and clinical immunology\| PubMed ID: 30959060	2019
Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet (London, England)\| PubMed ID: 31030987	2019
Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity. PloS one\| PubMed ID: 31199830	2019
IL-17 Production by γδ T Cells Is Critical for Inducing T17 Responses in the Female Genital Tract and Regulated by Estradiol and Microbiota. ImmunoHorizons\| PubMed ID: 31356161	2019
Follicular T cells: From stability to failure. Allergy\| PubMed ID: 31883377	2020
Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity. Frontiers in immunology\| PubMed ID: 32117293	2020
Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis. The Journal of allergy and clinical immunology\| PubMed ID: 33338539	2021
Perturbations to Homeostasis in Experimental Models Revealed Innate Pathways Driving Food Allergy. Frontiers in immunology\| PubMed ID: 33362786	2020
First contact: Serum amyloid A and pattern recognition in Th2 immunity. Allergy\| PubMed ID: 33590523	2021
Peanut allergen reaction thresholds during controlled food challenges in 2 Canadian randomized studies (Canada-ARM1 and PISCES). The journal of allergy and clinical immunology. In practice\| PubMed ID: 33607344	2021
Memory Generation and Re-Activation in Food Allergy. ImmunoTargets and therapy\| PubMed ID: 34136419	2021
Peanut allergy: Beyond the oral immunotherapy plateau. Clinical and translational allergy\| PubMed ID: 34429871	2021
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell\| PubMed ID: 35180381	2022
The Road Toward Transformative Treatments for Food Allergy. Frontiers in allergy\| PubMed ID: 35386642	2022
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection. PLoS pathogens\| PubMed ID: 35512020	2022
Peanut Oral Immunotherapy With or Without H and H Antihistamine Premedication for Peanut Allergy (PISCES): A Placebo-Controlled Randomized Clinical Trial. The journal of allergy and clinical immunology. In practice\| PubMed ID: 35643280	2022
Heterogeneity, subsets, and plasticity of T follicular helper cells in allergy. The Journal of allergy and clinical immunology\| PubMed ID: 36070826	2022
Reply to "Be smart in choosing antihistamines". The journal of allergy and clinical immunology. In practice\| PubMed ID: 37030931	2023
Production and use of antigen tetramers to study antigen-specific B cells. Nature protocols\| PubMed ID: 38243093	2024
Type 2-polarized memory B cells hold allergen-specific IgE memory. Science translational medicine\| PubMed ID: 38324637	2024
Author Correction: Production and use of antigen tetramers to study antigen-specific B cells. Nature protocols\| PubMed ID: 39719506	2024
Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1. Allergy\| PubMed ID: 39803817	2025
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis. bioRxiv : the preprint server for biology\| PubMed ID: 40027733	2025