Jianwen Chen

New Drug Research and Development Technology Center, Sun Yat-sen University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms. Cancer letters\| PubMed ID: 33741424	2021
[Study on morphological change in intestinal mucosa from injury to repair after hemorrhagic shock]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue\| PubMed ID: 15298805	2004
[Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA\| PubMed ID: 15837661	2005
Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World journal of gastroenterology\| PubMed ID: 16222741	2005
Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats. Journal of proteome research\| PubMed ID: 17081041	2006
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. European journal of pharmacology\| PubMed ID: 17537428	2007
Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas. Cytotechnology\| PubMed ID: 19898948	2009
Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 20638255	2010
Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways. Biological & pharmaceutical bulletin\| PubMed ID: 20686223	2010
Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake. Cytotechnology\| PubMed ID: 21076992	2010
Aspirin increases apolipoprotein-A-I-mediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1. Pharmacology\| PubMed ID: 21088444	2010
Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. European journal of medicinal chemistry\| PubMed ID: 21839550	2011
Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes. Molecular and cellular endocrinology\| PubMed ID: 22503866	2012
Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish. Marine drugs\| PubMed ID: 23429283	2013
Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-α partly via preventing p65-NFκB binding to NFATc4. Molecular and cellular endocrinology\| PubMed ID: 23518069	2013
Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression. ACS chemical biology\| PubMed ID: 23962138	2013
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. Bioorganic & medicinal chemistry\| PubMed ID: 24128814	2013
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 24220172	2013
Advanced glycation end products promote heart failure through inducing the immune maturation of dendritic cells. Applied biochemistry and biotechnology\| PubMed ID: 24610037	2014
Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinone IIA from Danshen in a mouse model of atherosclerosis. International journal of cardiology\| PubMed ID: 24814901	2014
ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice. Apoptosis : an international journal on programmed cell death\| PubMed ID: 25218423	2014
Advanced glycation end products induced immune maturation of dendritic cells controls heart failure through NF-κB signaling pathway. Archives of biochemistry and biophysics\| PubMed ID: 26163748	2015
NADPH oxidase inhibitor improves outcome of mechanical reperfusion by suppressing hemorrhagic transformation. Journal of neurointerventional surgery\| PubMed ID: 27075483	2017
NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion. Journal of neurointerventional surgery\| PubMed ID: 27325364	2017
Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives. European journal of medicinal chemistry\| PubMed ID: 28061346	2017
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway. Acta pharmacologica Sinica\| PubMed ID: 28552908	2017
Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension. Journal of medicinal chemistry\| PubMed ID: 28686445	2017
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway. Acta pharmacologica Sinica\| PubMed ID: 29323338	2018
Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors. European journal of medicinal chemistry\| PubMed ID: 29705710	2018
Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmac... Journal of medicinal chemistry\| PubMed ID: 30148362	2018
Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling. Hepatology (Baltimore, Md.)\| PubMed ID: 30180281	2019
Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy. Archives of biochemistry and biophysics\| PubMed ID: 30222953	2018
Murrangatin suppresses angiogenesis induced by tumor cell-derived media and inhibits AKT activation in zebrafish and endothelial cells. Drug design, development and therapy\| PubMed ID: 30288018	2018
Effects of Rich-Polyphenols Extract of Dendrobium loddigesii on Anti-Diabetic, Anti-Inflammatory, Anti-Oxidant, and Gut Microbiota Modulation in db/db Mice. Molecules (Basel, Switzerland)\| PubMed ID: 30544624	2018
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Journal of medicinal chemistry\| PubMed ID: 30916555	2019
Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors. European journal of medicinal chemistry\| PubMed ID: 31176097	2019
Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways. Pharmacological research\| PubMed ID: 31181334	2019
ZTW-41, a Potent Indolizinoquinoline-5,12-Dione Derivative Against Drug-Resistant and Bacteria. Microbial drug resistance (Larchmont, N.Y.)\| PubMed ID: 31441704	2020
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury. European journal of medicinal chemistry\| PubMed ID: 32061962	2020
Accurately Predicting Mutation-Caused Stability Changes from Protein Sequences Using Extreme Gradient Boosting. Journal of chemical information and modeling\| PubMed ID: 32203653	2020
METTL3 Promotes Tumorigenesis and Metastasis through BMI1 mA Methylation in Oral Squamous Cell Carcinoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 32621798	2020
Study of Inkjet-Printed Silver Films Based on Nanoparticles and Metal-Organic Decomposition Inks with Different Curing Methods. Micromachines\| PubMed ID: 32664692	2020
Bmi1 Severs as a Potential Tumor-Initiating Cell Marker and Therapeutic Target in Esophageal Squamous Cell Carcinoma. Stem cells international\| PubMed ID: 32884573	2020
Advances in Perovskite Light-Emitting Diodes Possessing Improved Lifetime. Nanomaterials (Basel, Switzerland)\| PubMed ID: 33406749	2021
Structure-aware protein solubility prediction from sequence through graph convolutional network and predicted contact map. Journal of cheminformatics\| PubMed ID: 33557952	2021
Deficiency of Mettl3 in Bladder Cancer Stem Cells Inhibits Bladder Cancer Progression and Angiogenesis. Frontiers in cell and developmental biology\| PubMed ID: 33681207	2021
Meta Learning for Low-Resource Molecular Optimization. Journal of chemical information and modeling\| PubMed ID: 33729779	2021
Corrigendum: Deficiency of Mettl3 in Bladder Cancer Stem Cells Inhibits Bladder Cancer Progression and Angiogenesis. Frontiers in cell and developmental biology\| PubMed ID: 33842490	2021
Synthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke. Neurochemistry international\| PubMed ID: 34147514	2021
Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway. Stem cell research & therapy\| PubMed ID: 34215344	2021
Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells. Ecotoxicology and environmental safety\| PubMed ID: 34229167	2021
Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway. Annals of palliative medicine\| PubMed ID: 34353086	2021
Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma. International journal of oral science\| PubMed ID: 34381012	2021
Structure-aware protein-protein interaction site prediction using deep graph convolutional network. Bioinformatics (Oxford, England)\| PubMed ID: 34498061	2021
A coarse-refine segmentation network for COVID-19 CT images. IET image processing\| PubMed ID: 34899976	2022
Nonsolid TiO Nanoparticles/PVDF Nanocomposite for Improved Energy Storage Performance. ACS applied materials & interfaces\| PubMed ID: 35112828	2022
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression. Cancer communications (London, England)\| PubMed ID: 35179319	2022
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury. European journal of medicinal chemistry\| PubMed ID: 35390713	2022
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway. European journal of pharmacology\| PubMed ID: 35490726	2022
A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System. International journal of molecular sciences\| PubMed ID: 35563421	2022
Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects. Journal of medicinal chemistry\| PubMed ID: 35666471	2022
Upregulation of miR-520c-3p via hepatitis B virus drives hepatocellular migration and invasion by the PTEN/AKT/NF-κB axis. Molecular therapy. Nucleic acids\| PubMed ID: 35795482	2022
Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element. Bioorganic chemistry\| PubMed ID: 35985158	2022
Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system. Archives of toxicology\| PubMed ID: 36173423	2022
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis alleviating inflammation and oxidative stress. Frontiers in pharmacology\| PubMed ID: 36238566	2022
Cytotoxicity and cell injuries of flavored electronic cigarette aerosol and mainstream cigarette smoke: A comprehensive in vitro evaluation. Toxicology letters\| PubMed ID: 36572074	2023
Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage. Frontiers in medicine\| PubMed ID: 36714100	2022
Cigarettes smoking and e-cigarettes using among university students: a cross-section survey in Guangzhou, China, 2021. BMC public health\| PubMed ID: 36882716	2023
Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone. Frontiers in pharmacology\| PubMed ID: 36969870	2023
Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 37399718	2023
The toxic effects of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal and renal systems in mice. Scientific reports\| PubMed ID: 37524767	2023
Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB. European journal of medicinal chemistry\| PubMed ID: 37651874	2023
Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice. Frontiers in toxicology\| PubMed ID: 37731664	2023
Predicting the effects of mutations on protein solubility using graph convolution network and protein language model representation. Journal of computational chemistry\| PubMed ID: 37933773	2024
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT. Gut\| PubMed ID: 38191266	2024
Effects of psychotherapy interventions on anxiety and depression in patients with gastrointestinal cancer: A systematic review and network meta-analysis. Journal of psychosomatic research\| PubMed ID: 38394712	2024
A cross-sectional study of the relationship between premenstrual syndrome and missed nursing care among female nursing staff. Heliyon\| PubMed ID: 38486753	2024
Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke. Environment international\| PubMed ID: 38508052	2024
Safety and feasibility analysis of rapid daratumumab infusion in Chinese patients with multiple myeloma. Cancer medicine\| PubMed ID: 38845476	2024
Efficacy of durvalumab plus chemotherapy in advanced biliary duct cancer and biomarkers exploration. Cancer immunology, immunotherapy : CII\| PubMed ID: 39235609	2024
The Neuroprotection of 1,2,4-Triazole Derivative by Inhibiting Inflammation and Protecting BBB Integrity in Acute Ischemic Stroke. CNS neuroscience & therapeutics\| PubMed ID: 39500736	2024
Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro. Ecotoxicology and environmental safety\| PubMed ID: 39626481	2025
Protective effects of a novel FS-Collagen hydrolysates against UV- and d-galactose-induced skin aging. Food science and biotechnology\| PubMed ID: 39758722	2025
Clinical benefit of continuation of PD-1 inhibitors after progression on first-line chemoimmunotherapy in metastatic gastric cancer and biomarker exploration. BMC cancer\| PubMed ID: 40413463	2025
Phytochemical Analysis and Neuroprotective Effect of Diels f. Stib Extracts. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 40430546	2025
Icariin Supplementation Alleviates Cognitive Impairment Induced by d-Galactose via Modulation of the Gut-Brain Axis. Journal of agricultural and food chemistry\| PubMed ID: 40481799	2025
α-Ketoglutarate Attenuates Oxidative Stress-Induced Neuronal Aging via Modulation of the mTOR Pathway. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 40872473	2025
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 40929882	2025
Discovery of a Novel COS/HS-Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis. Journal of medicinal chemistry\| PubMed ID: 40934896	2025
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40999870	2025
Design, synthesis, anti-acute ischemic stroke (AIS) effect of receptor-interacting protein kinase 1 (RIPK1) inhibitors containing quinazoline structure. Bioorganic chemistry\| PubMed ID: 41014837	2025
Efficacy and safety of TAS-102 plus Surufatinib in third and later line metastatic pancreatic cancer: a prospective, single center and biomarker exploratory, phase II study. Molecular cancer\| PubMed ID: 41039600	2025
DST-3, a Novel Modified Cryptotanshinone, Protects Against Pulmonary Fibrosis via Inhibiting STAT3/Smad Signaling Pathway and Improves Bioavailability. Pharmaceutics\| PubMed ID: 41155944	2025
Brain metabolic vulnerability in 18-F FDG PET/CT predict future depression risk in young cancer survivors. Translational psychiatry\| PubMed ID: 41173826	2025