Celia A. Schiffer

Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School

Affiliated withUniversity of Massachusetts Chan Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25355911	2014
A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif. Virology\| PubMed ID: 25461536	2014
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure (London, England : 1993)\| PubMed ID: 25914058	2015
Improving Viral Protease Inhibitors to Counter Drug Resistance. Trends in microbiology\| PubMed ID: 27090931	2016
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side. Journal of virology\| PubMed ID: 28298600	2017
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope. Cell reports\| PubMed ID: 29241550	2017
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. Scientific reports\| PubMed ID: 29760455	2018
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease. Structure (London, England : 1993)\| PubMed ID: 30146168	2018
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations. Journal of biomolecular NMR\| PubMed ID: 31243634	2019
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. mBio\| PubMed ID: 32234812	2020
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Nature communications\| PubMed ID: 32826914	2020
Interactions of APOBEC3s with DNA and RNA. Current opinion in structural biology\| PubMed ID: 33486429	2021
Unique structural solution from a V3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nature communications\| PubMed ID: 33495478	2021
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s. The Journal of biological chemistry\| PubMed ID: 34171358	2021
Viral proteases: Structure, mechanism and inhibition. The Enzymes\| PubMed ID: 34861941	2021
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance. Journal of molecular biology\| PubMed ID: 35183560	2022
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks. Structure (London, England : 1993)\| PubMed ID: 35290796	2022
HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 35550909	2022
Comprehensive fitness landscape of SARS-CoV-2 M reveals insights into viral resistance mechanisms. eLife\| PubMed ID: 35723575	2022
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nature communications\| PubMed ID: 35729165	2022
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Frontiers in immunology\| PubMed ID: 36172366	2022
Dual Inhibitors of Main Protease (M) and Cathepsin L as Potent Antivirals against SARS-CoV2. Journal of the American Chemical Society\| PubMed ID: 36356199	2022
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state. Nature communications\| PubMed ID: 36402773	2022
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease. Bioorganic chemistry\| PubMed ID: 36446201	2023
Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans. Immunity\| PubMed ID: 36804958	2023
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses\| PubMed ID: 36992489	2023
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues. European journal of medicinal chemistry\| PubMed ID: 37244161	2023
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS infectious diseases\| PubMed ID: 37390404	2023
Contributions of Hyperactive Mutations in M from SARS-CoV-2 to Drug Resistance. ACS infectious diseases\| PubMed ID: 38472113	2024
Increasing intracellular dNTP levels improves prime editing efficiency. Nature biotechnology\| PubMed ID: 39322763	2025
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance. Viruses\| PubMed ID: 39339895	2024
Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation. RSC advances\| PubMed ID: 39569122	2024
Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease. Viruses\| PubMed ID: 39861864	2025
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50. mBio\| PubMed ID: 40183562	2025
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 40244672	2025
HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation. Nature communications\| PubMed ID: 40593686	2025
Predicting the Impact of Drug Resistance Mutations on Inhibitor Potency with Molecular Dynamics and Machine Learning. The journal of physical chemistry. B\| PubMed ID: 41091504	2025