Isabel Alves

CNRS, University of Bordeaux

Research Area

Biography

Dr. Alves received his PhD in Chemical and Biomolecular Engineering from the University of Notre Dame. The research he conducts, while spanning many disciplines, is centered on the development of translational technologies, treatments, and techniques that can be utilized to have a positive impact on people’s lives.

He has extensive experience in: site-specific antibody modification, oriented antibody immobilization for advanced diagnostics, nanoparticle delivery, and packaging of pharmaceutical agents/enzymes to treat various diseases. Currently, Dr. Alves is an Assistant Professor at the Indiana University School of Medicine in the Department of Emergency Medicine with a joint appointment at Purdue in Biomedical Engineering. His multidisciplinary background affords him a unique perspective to tackle complex medical device and therapeutic development problems.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Relationships between membrane binding, affinity and cell internalization efficacy of a cell-penetrating peptide: penetratin as a case study. PloS one\| PubMed ID: 21915283	2011
Probing the kinetics of lipid membrane formation and the interaction of a nontoxic and a toxic amyloid with plasmon waveguide resonance. Chemical communications (Cambridge, England)\| PubMed ID: 24618747	2014
On the importance of electrostatic interactions between cell penetrating peptides and membranes: a pathway toward tumor cell selectivity? Biochimie\| PubMed ID: 25107405	2014
The role of tryptophans on the cellular uptake and membrane interaction of arginine-rich cell penetrating peptides. Biochimica et biophysica acta\| PubMed ID: 25445669	2015
Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane. Biochimica et biophysica acta\| PubMed ID: 25687973	2015
A Pathway Toward Tumor Cell-Selective CPPs? Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26202276	2015
Real time monitoring of membrane GPCR reconstitution by plasmon waveguide resonance: on the role of lipids. Scientific reports\| PubMed ID: 27824122	2016
Exploiting Benzophenone Photoreactivity To Probe the Phospholipid Environment and Insertion Depth of the Cell-Penetrating Peptide Penetratin in Model Membranes. Angewandte Chemie (International ed. in English)\| PubMed ID: 28485523	2017
Ligand activation induces different conformational changes in CXCR3 receptor isoforms as evidenced by plasmon waveguide resonance (PWR). Scientific reports\| PubMed ID: 28878333	2017
Study of G-Protein Coupled Receptor Signaling in Membrane Environment by Plasmon Waveguide Resonance. Accounts of chemical research\| PubMed ID: 30865424	2019
Improved Detection of Plasmon Waveguide Resonance Using Diverging Beam, Liquid Crystal Retarder, and Application to Lipid Orientation Determination. Sensors (Basel, Switzerland)\| PubMed ID: 30901964	2019
The Contribution of Differential Scanning Calorimetry for the Study of Peptide/Lipid Interactions. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30929231	2019
Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials. The FEBS journal\| PubMed ID: 31116904	2019
Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide. International journal of molecular sciences\| PubMed ID: 31505894	2019
Cholesterol impacts chemokine CCR5 receptor ligand-binding activity. The FEBS journal\| PubMed ID: 31738467	2020
Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides. EJNMMI research\| PubMed ID: 32124111	2020
Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP. Journal of cell science\| PubMed ID: 32434869	2020
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation. JCI insight\| PubMed ID: 32516140	2020
Direct Monitoring of GPCR Reconstitution and Ligand-Binding Activity by Plasmon Waveguide Resonance. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33582990	2020
The role of the lipid environment in the activity of G protein coupled receptors. Biophysical chemistry\| PubMed ID: 35344820	2022
The impact of lipid polyunsaturation on the physical and mechanical properties of lipid membranes. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 36368636	2023
Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular psychiatry\| PubMed ID: 36604603	2023
Editorial preface SFB-GEM 2021 special issue. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 36775007	2023
Correction: Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular psychiatry\| PubMed ID: 37550407	2023
Development of Radiopharmaceuticals for NPY Receptor-5 (Y5) Nuclear Imaging in Tumors by Synthesis of Specific Agonists and Investigation of Their Binding Mode. Bioconjugate chemistry\| PubMed ID: 37556437	2023
Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer. EMBO molecular medicine\| PubMed ID: 39962271	2025