a-case-of-primary-amebic-meningitis-with-acute-myocarditis

A Case of Primary Amebic Meningitis with Acute Myocarditis

Primary amebic meningitis is a rare, acute, fatal central nervous system disease caused by Naegleria fowleri infection. In the past, the resulting damage ...

Sichuan Provincial People's Hospital

University of Electronic Science and Technology of China

Due to the difficulty in sampling of metastatic tumors, patient selection is commonly based on results of primary tumor samples when metastatic samples are not available. However, due to tumor heterogeneity, metastatic tumors may be different from primary tumors in their phenotypes. The aim of this study was to investigate the expression of EGFR, HER2, and HER3 between primary and lymph node metastatic lesions of colorectal cancer. Paired primary tumors and lymph node metastases from 79 patients with colorectal cancer were retrospectively collected and analyzed for EGFR, HER2, and HER3 expression. High EGFR, HER2, and HER3 expression (2+ and 3+) was found in 64.2%, 66.0%, and 85.0% of primary tumors, and 56.8%, 46.0%, and 76.0% of lymph node metastases, respectively. Correlation rates between primary and metastatic lesions were 67.1%, 63.3%, and 74.7% for EGFR, HER2, and HER3, respectively. Stage IV tumors (with distant metastasis) had higher correlation rates of HER2 expression compared to stage III tumors (without distant metastasis) (P = 0.050). Moderate correlation rates in EGFR, HER2, and HER3 expression were observed between primary and metastatic lesions of colorectal cancer. Tumor stage or existence of distant metastasis could serve as potential predictive markers for the correlation of HER2 expression between primary tumors and lymph node metastases of colorectal cancer.

EGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer.

Triphasic waves (TWs) on electroencephalograms (EEGs) have predominantly been observed in adults, often associated with Creutzfeldt‒Jakob disease and metabolic encephalopathy. However, TWs have also been linked to various nonmetabolic and structural abnormalities. Additionally, reports of TWs in children are rare.

An 8-Year 5-Month-Old Boy with a Basal Ganglia Lesion with Triphasic Waves on Electroencephalogram.

A variety of diseases can complicate acute pancreatitis and myocarditis. As acute pancreatitis combined with myocarditis and thyrotoxicosis is rare, we report a case of acute pancreatitis combined with myocarditis and thyrotoxicosis.

Article	Year
EGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer. Scientific reports\| PubMed ID: 35902718	2022
An 8-Year 5-Month-Old Boy with a Basal Ganglia Lesion with Triphasic Waves on Electroencephalogram. Actas espanolas de psiquiatria\| PubMed ID: 39403907	2024
Case report: A case of acute pancreatitis with myocarditis and thyrotoxicosis. Frontiers in cardiovascular medicine\| PubMed ID: 40662134	2025

Jianing Cui

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