microfluidics-based-high-throughput-circulating-tumor-cell-sorting

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Circulating tumor cells (CTCs) serve as a promising biomarker for tracking cancer metastasis, progression, and recurrence. Liquid biopsy techniques ...

Shanghai Jiao Tong University School of Medicine

Multiple primary malignant tumors (MPMTs), usually associated with worse malignant behavior and prognosis comparing to a single primary tumor, and have recently been found to have an increasing incidence globally. However, the pathogenesis of MPMTs remains to be clarified. Here, we report a unique case of the coexistence of malignant melanoma (MM), papillary thyroid carcinoma (PTC), and clear-cell renal cell carcinoma (ccRCC) along with our perceptions on its pathogenesis.

Identification of BRAF, CCND1, and MYC mutations in a patient with multiple primary malignant tumors: a case report and review of the literature.

The purpose of this study was to develop a new and more comprehensive classification system for portal vein (PV) variations using three-dimensional visualization and evaluation (3DVE) and to discuss the prevalence rates and clinical implications of the variants.

Classification of variant portal vein anatomy based on three-dimensional CT: surgical implications.

Enhancing the nitric oxide (NO) signaling pathway is an effective strategy for treating pulmonary arterial hypertension (PAH). Previous research has found that Catestatin (CST) exerts a negative inotropic effect by upregulating NO production. However, the effect of CST on PAH remains unclear.

Catestatin alleviates PASMC phenotypic switching-mediated pulmonary arterial remodeling in a rat model of MCT-induced pulmonary arterial hypertension by promoting endothelium-derived no synthesis.

Sepsis is a life-threatening condition characterized by systemic inflammatory response syndrome, and often results in cardiac damage and poor prognosis. This study aimed to explore the protective effects of  polysaccharides (PCP) on sepsis-induced cardiac injury and elucidate the underlying molecular mechanisms. An  sepsis model was established, and an  myocardial cell model was induced using lipopolysaccharide (LPS) to mimic a sepsis environment. Histopathological analysis revealed morphological changes in the myocardial tissue, while apoptosis and oxidative stress in the myocardial cells were assessed using immunofluorescence staining. The Western blot assay was employed to measure the expression levels of CaMKII, NF-[Formula: see text]B, and NLRP3, and myocardial cell apoptosis was quantified by flow cytometry. Inflammatory cytokine levels were determined via ELISA. The results indicated that PCP treatment significantly alleviated myocardial injury, reduced myocardial apoptosis, and lowered the levels of inflammatory markers when compared to the sepsis group. Mechanistic studies revealed that PCP inhibited the P38/NF-[Formula: see text]B/NLRP3 signaling pathway activation induced by CaMKII to thereby mitigate apoptosis and the inflammatory response in sepsis-induced cardiomyocytes. In conclusion, PCP exerts a protective effect against sepsis-induced cardiac injury by inhibiting the CaMKII-mediated P38/NF-[Formula: see text]B/NLRP3 signaling pathway. This study provides a novel theoretical framework and identifies potential therapeutic targets for the prevention and treatment of sepsis-associated cardiac injury.

 Polysaccharides Attenuate Cardiac Injury by Inhibiting CaMKII-Mediated P38/NF-[Formula: see text]B/NLRP3 Signaling Pathway to Reduce Sepsis-Induced Apoptosis and Inflammation.

Corrigendum to "Catestatin alleviates PASMC phenotypic switching-mediated pulmonary arterial remodeling in a rat model of MCT-induced pulmonary arterial hypertension by promoting endothelium-derived NO synthesis" [Nitric Oxide158 (2025) 93-105].

Article	Year
Identification of BRAF, CCND1, and MYC mutations in a patient with multiple primary malignant tumors: a case report and review of the literature. World journal of surgical oncology\| PubMed ID: 37221610	2023
Classification of variant portal vein anatomy based on three-dimensional CT: surgical implications. Surgical and radiologic anatomy : SRA\| PubMed ID: 38963433	2024
Catestatin alleviates PASMC phenotypic switching-mediated pulmonary arterial remodeling in a rat model of MCT-induced pulmonary arterial hypertension by promoting endothelium-derived no synt... Nitric oxide : biology and chemistry\| PubMed ID: 40633831	2025
Polysaccharides Attenuate Cardiac Injury by Inhibiting CaMKII-Mediated P38/NF-[Formula: see text]B/NLRP3 Signaling Pathway to Reduce Sepsis-Induced Apoptosis and Inflammation. The American journal of Chinese medicine\| PubMed ID: 40769943	2025
Corrigendum to "Catestatin alleviates PASMC phenotypic switching-mediated pulmonary arterial remodeling in a rat model of MCT-induced pulmonary arterial hypertension by promoting endothelium... Nitric oxide : biology and chemistry\| PubMed ID: 40846596	2025

Zheyu Liu

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