architecting-resilience-global-freight-forwarding-with-causal-ai

Architecting Resilience in Global Freight Forwarding with a Causal AI Framework

The global freight forwarding industry confronts complex and cascading risks. Conventional analytical methods are often inadequate for managing these ...

Tongji University

We found that the difference in miR‑10b expression between the tumor tissue and adjacent non‑tumor tissue was significant. Outer periphery and portal vein serum miR‑10b concentrations were significantly higher than those of the control. However, the outer periphery vein miR‑10b concentrations were not significant when compared with the portal vein serum concentration in colorectal cancer. The expression levels of miR‑10b were associated with higher‑grade colorectal cancer. MiR‑10b levels were markedly elevated in lymph node metastasis-positive tumor tissue compared with those in lymph node metastasis-free tumor tissue, and were correlated with a downregulation in Hoxd10 expression. Rhoc protein expression in tumor tissue was significantly amplified when compared to that of the control tissue group. An inverse correlation between Hoxd10 and Rhoc in immunohistochemistry and western blot analysis was observed (P<0.05). MiR-10b expression was also inversely correlated with Hoxd10 protein expression (P<0.05). Thus, miR‑10b is potentially involved in the invasion of colorectal cancer.

MicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression.

Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cancer (CRC) metastasis and the associated molecular mechanisms remain elusive. The present study aimed to investigate whether miR-10b could promote invasion by targeting HOXD10 in CRC by exploring the association between miR-10b and HOXD10 expression in CRC patients. The findings revealed that miR-10b levels were elevated in the CRC specimens and significantly correlated with advanced clinical stage and lymph node metastasis. In addition, HOXD10 was a direct target of miR-10b, and the increased expression of RhoC and downregulation of HOXD10 correlated with the increased expression level of miR-10b. HOXD10 protein level was also markedly attenuated in lymph node metastasis-positive tumor tissues compared with lymph node metastasis-free tumor tissues. These findings suggest that miR-10b may stimulate the upregulation of RhoC through targeting HOXD10, thus promoting the invasion and migration in CRC tumor.

miR-10b promotes invasion by targeting HOXD10 in colorectal cancer.

Mesenchymal stem cells (MSCs) can migrate to tissue injury sites where they can induce multipotential differentiation and anti-inflammation effects to treat tissue injury. When traditional therapeutic methods do not work, MSCs are considered to be one of the best candidates for cell therapy. MSCs have been used for treating several injury- and inflammation-associated diseases, including liver cirrhosis. However, the therapeutic effect of MSCs is limited. In some cases, the anti-inflammatory function of naïve MSCs is not enough to rescue tissue injury.

Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice.

Laparoscopic transcystic common bile duct exploration and laparoscopic transductal common bile duct exploration in elderly patients with cholecystolithiasis combined with choledocholithiasis.

To compare the levels of serum pepsinogen (PG) in patients with gastric cancer (GC), patients with atrophic gastritis (AG), and healthy donors. Also, we explored the clinical value of PG detection for the diagnosis and treatment of GC.

Article	Year
MicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression. Oncology reports\| PubMed ID: 25606801	2015
miR-10b promotes invasion by targeting HOXD10 in colorectal cancer. Oncology letters\| PubMed ID: 27347170	2016
Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice. Stem cell research & therapy\| PubMed ID: 31133062	2019
Laparoscopic transcystic common bile duct exploration and laparoscopic transductal common bile duct exploration in elderly patients with cholecystolithiasis combined with choledocholithiasis... Chinese medical journal\| PubMed ID: 31261208	2019
Clinical Value of Pepsinogen in the Screening, Prevention, and Diagnosis of Gastric Cancer. Laboratory medicine\| PubMed ID: 34508270	2022

Yunfeng Wang

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